Volume 101, Issue 1, Jan 2017

Discussion on how DC-derived IL-6 inhibits the differentiation of Tfh cells with a Th2 phenotype.

IL-6/STAT3 signaling modulates the cytokine and transcription factor pattern of Tfh cells and controls IgE secretion in vivo.

Human DCs present standard HLA-DR peptides repertoires, but also C-terminal peptides from cytosolic proteins and Asp as a major cleavage residue, suggesting non-conventional processing pathways.

Review on genetic and clinical heterogeneity of inherited disorders associated to STAT family gene mutations.

Review on the properties of IL-32 and its immune modulation role in bacterial, viral, and other infectious diseases.

Review of phospholipases as key players in HIV-1 replication, and in associated dysfunctions of the immune system.

Review of constitutive cell-autonomous responses such as autophagy, metabolic stress, ER stress/UPR, and mitochondrial stress emerge as decisive regulators of innate immune response to microbes.

Review on DAMPs contribution to neuroinflammation in AD, activating signal transduction pathways through interactions with conserved pattern recognition receptors.

Review of the establishment and maintenance of innate immunity against staphylococci by dermal Mφ.

Review on how exposure to LPS alters signal transduction, chromatin organization, and gene expression to subsequent inflammatory stimulation.

Review of cytosolic and endosomal NA sensors in autoantibody production and systemic autoimmunity.

Review of how exposure of bacteria to antibiotics can affect how the immune system recognizes microbes.

Review of how the processing of NAs and their sensors is required for innate immune responses.

Review of how GBPs attack pathogens and activate inflammasomes, cell death, and innate immunity.

Review on the changes in immunometabolic pathways during sepsis.

Review on how bacterial secretion systems mediate activation and inhibition of inflammasome activation in innate immunity.

Review of how molecular signaling events driven by RP105 (CD180) shape the function of B cells, macrophages, and DCs.

Review of how targeting key upstream molecules at the recognition phase of innate immunity exert anti-inflammatory effects; a potential therapeutic regimen for inflammatory diseases.

Oxidized phospholipid induces the activation of NLRP3 inflammasome in macrophages, causing secretion of IL-1β mediated through production of mitochondrial ROS.

HO-1 has a critical role in regulating the infiltration of myeloid cells into the pregnant uterus.

Continuous IL-3 receptor activation and signaling are mandatory for IL-3 to regulate functional late responses of human blood basophils.

ArrB1/Rap2 complex is necessary for chemotactic polarization and migration in neutrophils.

Immuno-regulatory mechanism of PMNs that proteolytically disarms NK cell response.

LysoPCs elicit Hck translocation, causing nPKC (PKCδ) to activate cPKC (PKCγ), which results in priming of neutrophil NADPH oxidase.

Beneficial effects of HF and acetate production in a model of gout, by inducing pro-resolutive mediators and neutrophil apoptosis in the joint.

Cross-talk between tumor-associated macrophages and NK cells impacts NK cell phenotype and function via a contact-dependent mechanism.

The TLR1/2 agonist PAM3CSK4 alters brain and CSF barrier permeability, and is a potent stimulator of CNS inflammation and leukocyte invasion.

Lysates from CD8⁺ T cells transfer passive IL-17-mediated cellular immunity through elements of the TCR and S100; an opportunity to elucidate the structure, role, and therapeutic potential.

SiglecF⁺Gr1^hi eosinophils are distinct from the canonical SiglecF⁺Gr1- eosinophil population, and contain lymphocyte-targeting cytokines CXCL13 and IL-27.

Intersection of innate and adaptive immunity in viral infection and implications for vaccine design.

Distinct myeloid cells play a role in regulating the death vs. the survival of Th17 cells during HIV infection.