Volume 101, Issue 4, Apr 2017
Editorial
Editorial: No Trp, no B: surprising connectivity of diet, microbiome, aging, and adaptive immunity
Discussion on connection between diet, microbiome, and B-cells
Spotlight on Leading Edge Research
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice
Dietary Trp restriction linked to B cell development in BM and gut microbial composition.
Review
Updates in understanding the role of cyclophilin A in leukocyte chemotaxis
Review on CypA-dependent leukocytes chemotaxis as a possible therapeutic target in inflammatory diseases.
Reviews
Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes
Review on developmental signaling pathways in the differentiation and function of innate lymphoid cells and innate-like lymphocytes.
Inflammasome biology taught by Legionella pneumophila
Review on inflammasome activation following L. pneumophila infection, and its role in control of infection.
Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus
Review on strategies targeting cell-associated PRRs to elicit protective innate responses, and/or to augment vaccine efficacy against influenza.
Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection
Review on the role of NLRP3 inflammasomes during IAV infection.
The regulation of acute immune responses to the bacterial lung pathogen Legionella pneumophila
Review of the molecular and cellular immune response during L. pneumophila infection, and bacterial clearance in the lungs.
Primary Research
Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival
Data in support of a role for KAT7 in T cell development.
Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation
Early-life antibiotic treatment leads to a systemic stress response that affects T cell function later in life.
Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells
IL-37 is produced and secreted by antigen-presenting cells, including monocytes and DCs, where IL-37 may act as an alarmin.
Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance
Differences in acquisition and boosting of anti-malarial antibodies among African children exposed to malaria.
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage
Decreased ATM expression leads to accumulation of cytosolic DNA and neuroinflammation.
Transient reduction in IgA+ and IgG+ memory B cell numbers in young EBV-seropositive children: the Generation R Study
EBV persists in Ig class-switched B cells, even when derived from T cell-independent responses, and are transiently depleted in EBV-infected children.
Cell Development, Differentiation, & Trafficking
Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology
Study of osteoclast biology by generating a genetically modified ER-Hoxb8 precursors cell line with CRISPR/Cas9 technology
Substance P–mediated chemokine production promotes monocyte migration
Exposure of human PBMC to substance P results in production of chemokines, including MCP-1, which increases migration of human monocytes.
Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells
Dysfunctional memory CD8+ T cells differentiate in the maternal repertoire which promotes pregnancy success, but can threaten subsequent tissue grafts.
Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance
S100A8 promotes Treg generation by activity on modulating immature DCs in the presence of GM-CSF and IL-4.
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells
Calcineurin-Nfatc pathway promotes development and function of IFNγ-producing γδ T cells.
Chronic alcohol consumption inhibits peripheral NK cell development and maturation by decreasing the availability of IL-15
Chronic alcohol consumption impairs cNK development and maturation, but not ILC1s, by diminishing the availability of IL-15.
Inflammation, Extracellular Mediators, & Effector Molecules
CD11d β2 integrin expression on human NK, B, and γδ T cells
CD11d highly expressed on human NK, B, and γδ T cells, with special focus on γδ T cells and their subsets over time, in culture.
IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation
Systemic inflammation induces innate activation of effector-like CD8+ T cells to infiltrate the liver and produce IL-10.
Host Defense & Pathophysiology
NK cells require antigen-specific memory CD4+ T cells to mediate superior effector functions during HSV-2 recall responses in vitro
Cross-talk between HSV-2-specific CD4+ T cell and NK cells impacts NK cell function during secondary exposure to HSV-2 antigens.
Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection
Myeloid STAT3 promotes type I interferon response, and DC and NK cell activation, to protect mice against HSV-1 infection.
