Search
Close
Search
Advanced Search
Search Menu

Abstract

Pediatric-type diffuse high-grade gliomas (pHGG) are rare, aggressive central nervous system (CNS) malignancies newly classified in the 2021 World Health Organization (WHO) Classification. Extracranial metastasis of pHGG is uncommon, mostly in H3K27M-mutant diffuse midline gliomas. We report that a a 26-year - old H3-wildtype and IDH-wildtype (RTK1 subtype) male developed extensive extracranial metastases after surgery. Despite radiochemotherapy, the disease spread. This case shows extracranial metastasis potential in pediatric - type gliomas, especially RTK1. Recent studies indicate about half of Adolescent and Young Adult (AYA) high - grade gliomas are pediatric - type, and around 40% of extracranial metastases occur in AYA patients. Recognizing this metastatic potential, especially in AYA, is significant for better outcomes.

Information Accepted manuscripts
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
PDF
This content is only available as a PDF.

Author notes

Jiawen Wu and Rongqiao Zheng are co-first authors and contributed equally to this study

© The Author(s) 2025. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].
Topic:
Issue Section:
Molecular Tumor Board Case Report
Download all slides
  • Supplementary data

    • Supplementary data

    vdaf069_suppl_Supplementary_Figure_S1 - jpeg file
    vdaf069_suppl_Supplementary_Figure_S2 - jpeg file
    vdaf069_suppl_Supplementary_Table_S1 - docx file
    vdaf069_suppl_Supplementary_Table_S2 - docx file