Special Call for Papers
Translational Geroscience
Biological and Medical Sciences sections of The Journals of Gerontology, Series A on Translational Geroscience
The growing field of geroscience is focused on discovering and translating methods and interventions to prevent, minimize, or reverse age-related biological and physiological changes that increase the susceptibility of older individuals to multimorbidity and associated adverse outcomes such as disability, frailty, reduced quality of life, and early mortality. Owing to the development of the concept of geroscience, aging is now understood as the progressive decline in biological resilience mechanisms that lead to functional deficit accumulation, chronic diseases, and, eventually, a reduced ability to maintain health and independence in the face of environmental and social challenges (Fourth summit: Geroscience for the next generation. National Institute on Aging. Accessed July 14, 2023).
Another important goal for researchers in the field of aging is to elucidate the molecular origins of functional deficit accumulation. This knowledge is a necessary foundation for developing and testing interventions that could act in advance of deficit accumulation (geroprotective) and those that could reverse deficit accumulation (gerotherapeutic). Geroscience is a field of research whose outcomes are essential for the practice of geriatric medicine. In this respect, biomarkers of aging can be used as readouts in preclinical experiments and then used to create and validate parallel investigations and clinical trials in humans. In addition, new drugs could target one or several of the biological hallmarks of aging to prevent or treat age-related conditions. What distinguishes geroscience from other fields of medicine and biology is its core hypothesis: namely that any intervention that slows the rate of aging will impact multiple deficits and therefore delay the development of chronic diseases, reduce multimorbidity and improve function and resilience in older people. The fundamental challenge for geroscience is to effectively advance discoveries of the mechanisms of aging into candidate interventions and biomarkers and then advance the translation of those interventions to clinical trials. (Fourth summit: Geroscience for the next generation. National Institute on Aging. Accessed July 14, 2023).
To address this challenge, The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences is planning a recurring section dedicated to translational geroscience.
Topics that will be considered include but are not limited to:
- Biological determinants of health and disparities in aging.
- Populations for geroscience: high and low burdens of functional deficits and morbidities.
- Multimorbidities and geriatric syndromes.
- Methods for measuring health.
- Mathematical modeling of aging and health for geroscience.
- Biomarkers for geroscience.
- Geroscience as medicine in the clinic and community.
- Geroscience clinical trials.
Please review journal scopes in determining which section (Biological or Medical Sciences) to submit the manuscript. Manuscripts must be submitted via the ScholarOne Submission websites; Journal of Gerontology: Biological Sciences and Journal of Gerontology: Medical Sciences. The editors may transfer manuscripts between sections to ensure they are placed in the appropriate section. Full manuscripts will be evaluated using the journal’s usual peer-review process. Submission of a manuscript does not guarantee the manuscript will be accepted for publication.
Authors are advised to carefully read and follow formatting directions detailed in the Author Guidelines for the Biological and Medical Sciences sections of The Journals of Gerontology, Series A.
Manuscript Submission Deadline: Rolling submissions. No Deadline
Articles will be available in Advance Access shortly after final acceptance with anticipated issue assignment within 60 days.
