Volume 111, Issue 11, November 2024

In this meta-analysis, the most common actionable and undruggable mutations in resected intrahepatic cholangiocarcinoma are determined. Among the heterogeneous genetic landscape of this cancer, only mutations in three genes are associated with long-term outcomes, thus helping to determine cases with a favourable or an impaired prognosis after resection.

In this multinational collaborative study, comprising 603 women with breast cancer from Sweden, the UK, and Australia, it is shown that chest wall perforator flaps are effective with regards to avoiding mastectomy in women without any other technical alternatives. The procedure was undertaken as day surgery in 69% of patients, with a perioperative morbidity of 3.3%. Conversion to mastectomy was as low as 1.5% and short-term follow-up was reassuring in terms of local control, risk of distant metastasis, and breast cancer-specific survival.

This nationwide study of outcomes of juxtarenal abdominal aortic aneurysm repair in Sweden over a 3-year interval shows that survival after repair is similar for open surgical repair and fenestrated endovascular aneurysm repair. Both perioperative survival and survival up to 3 years are similar in both groups. The patients selected for open surgical repair and fenestrated endovascular aneurysm repair have significant demographic differences.

Postponement of surgery in the days or weeks before the patient is admitted for surgery, as distinct from cancellation on the planned day of surgery, can be devastating for patients and an inefficient use of finite resources. Postponement rates across trusts varied from 31.9% to 1.0% across the 16 trusts studied. Minimizing postponements and improving preoperative assessment efficiency should be part of wider initiatives to streamline perioperative pathways.

A machine learning model was developed to predict the risk of early recurrence after surgery for gallbladder cancer, using an international cohort of patients. The random forest model had the highest accuracy, with an area under the curve of 76.4. An online calculator was developed.