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Original Article
Perineal wound complications after total neoadjuvant therapy or chemoradiotherapy followed by abdominoperineal excision in patients with high-risk locally advanced rectal cancer in the RAPIDO trial
Wouter H Zwart and others
In the RAPIDO trial, total neoadjuvant therapy and chemoradiotherapy resulted in a similar incidence of perineal wound complications in patients with high-risk locally advanced rectal cancer who underwent abdominoperineal excision.
Original Article
Multimodal carcinoembryonic antigen-targeted fluorescence and radio-guided cytoreductive surgery for peritoneal metastases of colorectal origin: single-arm confirmatory trial
Aaya Darai and others
The trial results indicate that multimodal imaging with 111In-labelled dodecane tetra-acetic acid–labetuzumab-IRDye800CW can enhance future cancer treatment by significantly improving tumour detection and surgical precision. This technique allows the intraoperative identification of additional malignant lesions, leading to more thorough resections and potentially altering surgical strategies.
Original Article
Arterial resection and divestment in pancreatic cancer surgery in the era of multidisciplinary treatment: decadal comparative study
Yuki Hirose and others
Compared with the former interval (2010–2015), the postoperative morbidity rate and early recurrence decreased, and overall survival and postrecurrence survival prolonged in the latter interval (2016–2021) for pancreatic cancer patients with arterial involvement undergoing pancreatectomy including arterial resection. Within the context of modern multidisciplinary treatment, radical resection including arterial resection can be justified for pancreatic cancer patients with arterial involvement at expert centres, considering the acceptable perioperative risk and the potential for prolonged survival.
Systematic review
Venous thromboembolism risk in the postoperative interval during the COVID-19 pandemic: meta-analysis
Andrew Jackson and others
This systematic review and meta-analysis investigates the incidence of postoperative venous thromboembolism (VTE) during the COVID-19 pandemic, revealing significantly higher rates in patients with perioperative COVID-19 compared with those without. Data from 17 studies involving >3 million patients showed VTE rates were raised in those undergoing total joint arthroplasty, other orthopaedic surgery, and emergency general and gastrointestinal surgery. The findings underscore the need for further research to understand VTE risk variations related to COVID-19 variants and vaccination.
Original Article
Long-term follow-up of infection, malignancy, thromboembolism, and all-cause mortality risks after splenic artery embolization for blunt splenic injury: comparison with splenectomy and conservative management
Jen-Fu Huang and others
Non-operative management for blunt splenic injuries, including splenic artery embolization, is preferred, but its long-term risks need further investigation. Long-term infection, malignancy, thromboembolism, and all-cause mortality risks were not significantly different between the splenic artery embolization and conservative treatment groups. In contrast, patients who underwent splenectomies had increased infection, malignancy, thromboembolism, and all-cause mortality risks.
Guideline
Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children
Martin Salö and others
Background Acute appendicitis is one of the most common causes of acute abdominal pain. Differences in the management of this large group of patients has important consequences for the patients and the healthcare system. Controversies regarding the understanding of the natural course of the ...
Original Article
Effect of Enhanced Recovery After Surgery compliance on postoperative venous thromboembolism
Kristin A Black and others
In a cohort of 8118 adult patients, 1.5% experienced a postoperative venous thromboembolism. Enhanced Recovery After Surgery compliance is associated with decreased odds of postoperative venous thromboembolism across multiple surgical disciplines.
Original Article
α-Fetoprotein model versus Milan criteria in predicting outcomes after hepatic resection for hepatocellular carcinoma: multicentre study
Chao Li and others
This large multicentre study of 1968 patients who underwent hepatic resection for HCC with curative intent demonstrated that the French AFP model outperformed the widely used Milan criteria in predicting post-resection recurrence and survival.
Systematic review
Circular staplers and anastomotic leakage in colorectal surgery: meta-analysis
Claudio Fiorillo and others
According to our meta-analysis, circular staplers with a large diameter, manual technology, and the double-stapling technique are associated with a higher anastomotic leakage rate after left colorectal surgery, while no significant difference was observed between two- and three-row circular staplers. The importance of these findings lies in their relevance for selecting the appropriate type of circular stapler in left colorectal surgery.
Original Article
Western and Eastern experience in treating perihilar cholangiocarcinoma: retrospective bi-centre study
Hannes Jansson and others
This study analysed current outcomes after resection for perihilar cholangiocarcinoma in a large bi-institutional Western–Eastern cohort to identify prognostic factors. Advanced tumour stage and radial margin positivity were found to contribute to poor long-term survival in the Western cohort. A higher burden of co-morbidity and a higher rate of extended resections with smaller remnant liver volume influenced the Western postoperative mortality rate.

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