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Book cover for Oxford Handbook of Clinical Specialties (11 edn) Oxford Handbook of Clinical Specialties (11 edn)
Book cover for Oxford Handbook of Clinical Specialties (11 edn) Oxford Handbook of Clinical Specialties (11 edn)
Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always … More Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

See p314  for  children  and p9  for  obstetric reference intervals.

graphicAll laboratory discourse is probabilistic. graphicDrugs may interfere with any chemical method; as these effects may be method dependent, it is difficult for us to be aware of all possibilities. If in doubt, discuss with the lab.

SubstanceSpecimenNormal value

Adrenocorticotrophic hormone

P

<80ng/L

Alanine aminotransferase (alt)

P

5–35IU/L

Albumin

P

35–50g/L

Aldosterone

P**

100–500pmoL/L

Alkaline phosphatase

P

30–300IU/L (adults)

α-fetoprotein

S

<10kU/L

α-amylase

P

0–180 Somogyi U/dL

Angiotensin II

P**

5–35pmol/L

Antidiuretic hormone (adh)

P

0.9–4.6pmol/L

Aspartate transaminase

P

5–35IU/L

Bicarbonate

P

24–30mmol/L

Bilirubin

P

3–17µmol/L (0.25–1.5mg/100/mL)

Calcitonin

P

<0.1mcg/L

Calcium (ionized)

P

1.0–1.25mmol/L

Calcium (total)

P

2.12–2.65mmol/L

Chloride

P

95–105mmol/L

*Cholesterol

P

<5mmol/L desired

    Triglycerides

P

0.15–1.9mmol/L

    ldl

P

1.55–4.4mmol/L

    hdl

P

0.9–1.93mmol/L

Cortisol

P

a.m. 450–700nmol/L

 

midnight 80–280nmol/L

Creatine kinase (ck)

P

♂ 25–195IU/L; ♀ 25–170

Creatinine (related to lean body mass)

P

70–≤150µmol/L

Ferritin

P

12–200mcg/L

Folate

S

2.1mcg/L

Follicle-stimulating hormone (fsh)

P/S

2–8U/L (luteal):

 

ovulatory peak 8–15

 

follicular phase, & ♂: 0.5–5

 

postmenopausal: >30

Gamma-glutamyl transpeptidase

P

♂ 11–51; ♀ 7–33IU/L

Glucose (fasting)

P

3.5–5.5mmol/L

Growth hormone

B

<20mU/L

HbA1c  ifcc

P

20–42mmol/mol

Iron

S

♂ 14–31µmol/L; ♀ 11–30

Lactate dehydrogenase (ldh)

P

70–250U/L

Lead

B

<1.8mmol/L

Luteinizing hormone (lh)

P/S

premenopausal: 3–16U/L

 

follicular: 3–12

 

ovulatory peak: 20–80

 

luteal: 3–16

 

postmenopausal: >l30

Magnesium

P

0.75–1.05mmol/L

Osmolality

P

278–305mosmol/kg

Parathyroid hormone (pth)

P

<0.8–8.5pmol/L

Phosphate (inorganic)

P

0.8–1.45mmol/L

Potassium

P

3.5–5.0mmol/L

Prolactin

P

♂ <450u/L; ♀ <600U/L

Prostate-specific antigen

P

0–4 mcg/mL

Protein (total)

P

60–80g/L

Red cell folate

B

0.36–1.44µmol/L

 

(160–640mcg/L)

Renin (erect/recumbent)

P**

2.8–4.5/1.1–2.7pmol/mL/h

Sodium

P

135–145mmol/L

Thyroid-binding globulin (tbg)

P

7–17mg/L

Thyroid-stimulating hormone (tsh) NR widens with age

P

0.5–5.7mU/L

Thyroxine (t4)

P

70–140nmol/L

Thyroxine (free)

P

9–22pmol/L

Total iron binding capacity

S

54–75µmol/L

Tri-iodothyroine (t3)

P

1.2–3.0nmol/L

Urea

P

2.5–6.7mmol/L

Urate

P

♂ 210–480µmol/L

 

♀ 150–390µmol/L

Vitamin b12

S

0.13–0.68nmol/L (>150ng/L)

Vitamin D

S

60–105nmol/L

SubstanceSpecimenNormal value

Adrenocorticotrophic hormone

P

<80ng/L

Alanine aminotransferase (alt)

P

5–35IU/L

Albumin

P

35–50g/L

Aldosterone

P**

100–500pmoL/L

Alkaline phosphatase

P

30–300IU/L (adults)

α-fetoprotein

S

<10kU/L

α-amylase

P

0–180 Somogyi U/dL

Angiotensin II

P**

5–35pmol/L

Antidiuretic hormone (adh)

P

0.9–4.6pmol/L

Aspartate transaminase

P

5–35IU/L

Bicarbonate

P

24–30mmol/L

Bilirubin

P

3–17µmol/L (0.25–1.5mg/100/mL)

Calcitonin

P

<0.1mcg/L

Calcium (ionized)

P

1.0–1.25mmol/L

Calcium (total)

P

2.12–2.65mmol/L

Chloride

P

95–105mmol/L

*Cholesterol

P

<5mmol/L desired

    Triglycerides

P

0.15–1.9mmol/L

    ldl

P

1.55–4.4mmol/L

    hdl

P

0.9–1.93mmol/L

Cortisol

P

a.m. 450–700nmol/L

 

midnight 80–280nmol/L

Creatine kinase (ck)

P

♂ 25–195IU/L; ♀ 25–170

Creatinine (related to lean body mass)

P

70–≤150µmol/L

Ferritin

P

12–200mcg/L

Folate

S

2.1mcg/L

Follicle-stimulating hormone (fsh)

P/S

2–8U/L (luteal):

 

ovulatory peak 8–15

 

follicular phase, & ♂: 0.5–5

 

postmenopausal: >30

Gamma-glutamyl transpeptidase

P

♂ 11–51; ♀ 7–33IU/L

Glucose (fasting)

P

3.5–5.5mmol/L

Growth hormone

B

<20mU/L

HbA1c  ifcc

P

20–42mmol/mol

Iron

S

♂ 14–31µmol/L; ♀ 11–30

Lactate dehydrogenase (ldh)

P

70–250U/L

Lead

B

<1.8mmol/L

Luteinizing hormone (lh)

P/S

premenopausal: 3–16U/L

 

follicular: 3–12

 

ovulatory peak: 20–80

 

luteal: 3–16

 

postmenopausal: >l30

Magnesium

P

0.75–1.05mmol/L

Osmolality

P

278–305mosmol/kg

Parathyroid hormone (pth)

P

<0.8–8.5pmol/L

Phosphate (inorganic)

P

0.8–1.45mmol/L

Potassium

P

3.5–5.0mmol/L

Prolactin

P

♂ <450u/L; ♀ <600U/L

Prostate-specific antigen

P

0–4 mcg/mL

Protein (total)

P

60–80g/L

Red cell folate

B

0.36–1.44µmol/L

 

(160–640mcg/L)

Renin (erect/recumbent)

P**

2.8–4.5/1.1–2.7pmol/mL/h

Sodium

P

135–145mmol/L

Thyroid-binding globulin (tbg)

P

7–17mg/L

Thyroid-stimulating hormone (tsh) NR widens with age

P

0.5–5.7mU/L

Thyroxine (t4)

P

70–140nmol/L

Thyroxine (free)

P

9–22pmol/L

Total iron binding capacity

S

54–75µmol/L

Tri-iodothyroine (t3)

P

1.2–3.0nmol/L

Urea

P

2.5–6.7mmol/L

Urate

P

♂ 210–480µmol/L

 

♀ 150–390µmol/L

Vitamin b12

S

0.13–0.68nmol/L (>150ng/L)

Vitamin D

S

60–105nmol/L

Arterial blood gases

pH: 7.35–7.45

PaCO2:        4.7–6.0kPa

PaO2: <10.6kPa

Base excess: ± 2mmol/L

 

nb: 7.6mmHg = 1kPa (atmospheric pressure ≈ 100kPa)

Arterial blood gases

pH: 7.35–7.45

PaCO2:        4.7–6.0kPa

PaO2: <10.6kPa

Base excess: ± 2mmol/L

 

nb: 7.6mmHg = 1kPa (atmospheric pressure ≈ 100kPa)

*

Desired upper limit of cholesterol would be <5mmol/L.

**

The sample requires special handling: contact the laboratory.

Range is significantly different in pregnancy, see p9.

Keys: P = plasma (heparin bottle); S = serum (clotted; no anticoagulant); B = whole blood (edetic acid—edta—bottle); iu = international unit ♂ = male; ♀ = female.

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