The Oxford Handbook of Research Ethics
The Oxford Handbook of Research Ethics
Ana S. Iltis, Professor of Philosophy; Carlson Professor of University Studies; Director, Center for Bioethics, Health and Society, Wake Forest University, Winston-Salem, North Carolina, U.S.A.
Douglas MacKay, Associate Professor, Department of Public Policy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
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Abstract
The Oxford Handbook of Research Ethics provides a critical overview of the ethics of human subjects research within multiple disciplines and fields, including biomedicine, public health, psychiatry, sociology, political science, and public policy. Featuring forty-four innovative chapters by leading research ethicists, it aims to improve scholarship in research ethics by encouraging cross-disciplinary engagement with critical issues concerning the treatment of research participants. Part 1 of the volume, The Practice and Institutional Context of Human Subjects Research, orients readers to the research ethics literature through discussion of historical, regulatory, and other features of human subjects research. It includes chapters on the nature of human subjects research, the highs and lows of research, and the regulations that govern it. Part 2, Key Concepts and Principles of Research Ethics, features cutting-edge critical overviews of the central ethical principles and requirements used to evaluate research, including chapters on respect for persons, social value, risk-benefit assessment, equipoise, and fair subject selection, among others. Part 3, Research Areas and Methods, explores how these principles and requirements apply across different disciplines and methodologies. It features chapters on the ethics of novel trial designs such as multi-arm platform trials as well as chapters addressing ethical issues that arise in different fields, including genetics and genomics, public health, behavioral science, political science, and public policy. Part 4, Research Participant Populations, concludes the volume with chapters addressing ethical questions that arise with research concerning certain populations, including Indigenous people, racial and ethnic minorities, women, and people with disabilities, among others.
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Front Matter
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1
Introduction
Ana S. Iltis andDouglas MacKay
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Part 1 The Practice and Institutional Context of Human Subjects Research
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2
What Is Human Subjects Research?
Kirstin Borgerson
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3
The Highs and Lows of Research: Exploring Value in Research Cases
Will Schupmann andChristine Grady
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4
Guidelines, Codes, and Regulations
Daniel K. Nelson andDavid Forster
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5
Independent Review, Data Safety Monitoring, and Research Oversight
Toby L. Schonfeld
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6
Research Ethics Consultation
Marion Danis
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7
Advocacy and Research
Rebecca Dresser
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2
What Is Human Subjects Research?
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Part 2 Key Concepts and Principles of Research Ethics
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8
Respect for Persons
Joseph Millum andDanielle Bromwich
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9
Coercion, Exploitation, and Undue Inducement
Trisha Phillips
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10
The Social Value of Research and Health Research Priority-Setting
Danielle M. Wenner
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11
Ethical Evaluation of Research Risks and Potential Benefits
Annette Rid
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12
Equipoise: Integrating Social Value and Equal Respect in Research with Humans
Alex John London
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13
Fair Subject Selection in Clinical and Social Scientific Research
Douglas MacKay
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14
Research That Engages Community and Patient Partners
Emily E. Anderson andRyan Spellecy
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15
Ancillary-Care Obligations
Henry S. Richardson
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8
Respect for Persons
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Part 3 Research Areas and Methods
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16
Old and New Trial Designs: Individually Randomized Controlled Trials, Cluster Randomized Trials, Biomarker-Stratified Trials, and Multi-Arm Platform Trials
Charles Weijer andSpencer Phillips Hey
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17
Comparative Effectiveness Research, Learning Health Systems, and Pragmatic Randomized Controlled Trials: The Need for Both Clinical and Research Ethics
Scott Y. H. Kim
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18
Genetic and Genomics Research
Lisa S. Parker
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19
Research on Emerging Biotechnologies
Nancy M. P. King andChristine Nero Coughlin
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20
Clinical Translation, Ethics, and Policy
Jonathan Kimmelman
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21
Surgical Research
Anji Wall andGiuliano Testa
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22
Research during Pandemics and Epidemics
Nir Eyal
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23
The Ethics of Public Policy Experiments: Lessons from Clinical Research Ethics
Douglas MacKay
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24
The Ethical Challenges of Political Science Field Experiments
Scott Desposato
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25
Current Issues in Behavioral and Social Science Research Ethics
James M. DuBois andEmily C. Lisi
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26
Sociological Research Ethics: Contributions and Controversies
Farida Fozdar andMark Israel
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27
Big Data and Internet Research
G. Owen Schaefer
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28
Research Ethics in Citizen Science
Lisa M. Rasmussen
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16
Old and New Trial Designs: Individually Randomized Controlled Trials, Cluster Randomized Trials, Biomarker-Stratified Trials, and Multi-Arm Platform Trials
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Part 4 Research Participant Populations
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29
Decolonizing Research Ethics: Best Practices for the Ethical Conduct of Research Involving Indigenous Peoples
Fern Brunger and others
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30
Closing the Gap: Improving Women’s Health through Research Inclusion
Anna C. Mastroianni andLeslie Meltzer Henry
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31
Minoritized Racial and Ethnic Groups
Stephanie Hoover and others
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32
Research in Pregnancy: Frameworks for Addressing a Neglected and Complex Study Population
Margaret Olivia Little and others
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33
People with Disabilities in Human Subjects Research: A History of Exploitation, a Problem of Exclusion
Alicia Ouellette
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34
The Ethics of Pediatric Research
Seema K. Shah
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35
Research in Adults with Diminished Capacity
Neal W. Dickert andEmily A. Largent
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36
Psychiatric Research Ethics
Dominic Sisti andWilliam R. Smith
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37
A Puzzling Anomaly: Decision-Making Capacity and Research on Addiction
Louis C. Charland
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38
The Ethics of Studying the Origins of Sexual Orientation and Gender Identification
Timothy F. Murphy
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39
Healthy Volunteers
Jill A. Fisher
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40
Ethical Issues in Research Involving Employees and Students
David B. Resnik
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41
International Health Research Ethics
Bridget Pratt
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42
Military Medical Research Ethics: Investigational Drugs, Clinical Trials, and Enhancement
Michael L. Gross
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43
Vulnerability in Research with Prisoners
Paul P. Christopher
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44
Research on the Newly Dead
Catherine M. Hammack-Aviran
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45
Biomedical Research Using Nonhuman Animals: Ethics and Translational Value
Rebecca L. Walker
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29
Decolonizing Research Ethics: Best Practices for the Ethical Conduct of Research Involving Indigenous Peoples
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August 2024 | 57 |
August 2024 | 10 |
August 2024 | 10 |
August 2024 | 4 |
August 2024 | 5 |
August 2024 | 10 |
August 2024 | 4 |
August 2024 | 7 |
August 2024 | 24 |
August 2024 | 5 |
August 2024 | 6 |
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September 2024 | 10 |
September 2024 | 6 |
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September 2024 | 5 |
September 2024 | 9 |
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September 2024 | 10 |
September 2024 | 2 |
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September 2024 | 28 |
September 2024 | 2 |
September 2024 | 18 |
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September 2024 | 28 |
September 2024 | 7 |
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September 2024 | 9 |
September 2024 | 23 |
September 2024 | 29 |
September 2024 | 17 |
September 2024 | 10 |
September 2024 | 9 |
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September 2024 | 1 |
September 2024 | 10 |
September 2024 | 6 |
September 2024 | 2 |
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September 2024 | 15 |
September 2024 | 10 |
September 2024 | 36 |
September 2024 | 5 |
September 2024 | 18 |
October 2024 | 9 |
October 2024 | 6 |
October 2024 | 24 |
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October 2024 | 2 |
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October 2024 | 32 |
October 2024 | 11 |
October 2024 | 13 |
October 2024 | 11 |
October 2024 | 12 |
October 2024 | 2 |
October 2024 | 7 |
October 2024 | 109 |
October 2024 | 3 |
October 2024 | 4 |
October 2024 | 10 |
October 2024 | 13 |
October 2024 | 58 |
October 2024 | 23 |
October 2024 | 75 |
October 2024 | 25 |
October 2024 | 2 |
October 2024 | 19 |
October 2024 | 12 |
October 2024 | 8 |
October 2024 | 2 |
October 2024 | 11 |
October 2024 | 11 |
October 2024 | 4 |
October 2024 | 8 |
October 2024 | 7 |
October 2024 | 15 |
October 2024 | 3 |
October 2024 | 23 |
October 2024 | 1 |
October 2024 | 5 |
November 2024 | 11 |
November 2024 | 6 |
November 2024 | 40 |
November 2024 | 8 |
November 2024 | 68 |
November 2024 | 4 |
November 2024 | 2 |
November 2024 | 19 |
November 2024 | 4 |
November 2024 | 4 |
November 2024 | 21 |
November 2024 | 21 |
November 2024 | 9 |
November 2024 | 3 |
November 2024 | 9 |
November 2024 | 15 |
November 2024 | 9 |
November 2024 | 8 |
November 2024 | 4 |
November 2024 | 10 |
November 2024 | 56 |
November 2024 | 11 |
November 2024 | 7 |
November 2024 | 42 |
November 2024 | 9 |
November 2024 | 26 |
November 2024 | 15 |
November 2024 | 7 |
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November 2024 | 50 |
November 2024 | 13 |
November 2024 | 4 |
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November 2024 | 4 |
November 2024 | 8 |
November 2024 | 25 |
November 2024 | 8 |
November 2024 | 7 |
November 2024 | 4 |
November 2024 | 23 |
November 2024 | 17 |
November 2024 | 29 |
November 2024 | 14 |
November 2024 | 11 |
November 2024 | 15 |
November 2024 | 4 |
November 2024 | 19 |
December 2024 | 15 |
December 2024 | 10 |
December 2024 | 7 |
December 2024 | 32 |
December 2024 | 7 |
December 2024 | 9 |
December 2024 | 24 |
December 2024 | 6 |
December 2024 | 20 |
December 2024 | 9 |
December 2024 | 13 |
December 2024 | 6 |
December 2024 | 35 |
December 2024 | 9 |
December 2024 | 26 |
December 2024 | 10 |
December 2024 | 8 |
December 2024 | 28 |
December 2024 | 2 |
December 2024 | 11 |
December 2024 | 37 |
December 2024 | 7 |
December 2024 | 15 |
December 2024 | 60 |
December 2024 | 17 |
December 2024 | 9 |
December 2024 | 19 |
December 2024 | 17 |
December 2024 | 26 |
December 2024 | 23 |
December 2024 | 33 |
December 2024 | 22 |
December 2024 | 6 |
December 2024 | 8 |
December 2024 | 6 |
December 2024 | 10 |
December 2024 | 24 |
December 2024 | 12 |
December 2024 | 15 |
December 2024 | 6 |
December 2024 | 39 |
December 2024 | 33 |
December 2024 | 6 |
December 2024 | 13 |
December 2024 | 9 |
December 2024 | 17 |
December 2024 | 7 |
December 2024 | 7 |
January 2025 | 4 |
January 2025 | 5 |
January 2025 | 3 |
January 2025 | 46 |
January 2025 | 20 |
January 2025 | 1 |
January 2025 | 67 |
January 2025 | 3 |
January 2025 | 12 |
January 2025 | 1 |
January 2025 | 7 |
January 2025 | 7 |
January 2025 | 5 |
January 2025 | 2 |
January 2025 | 6 |
January 2025 | 4 |
January 2025 | 5 |
January 2025 | 4 |
January 2025 | 6 |
January 2025 | 7 |
January 2025 | 2 |
January 2025 | 3 |
January 2025 | 7 |
January 2025 | 9 |
January 2025 | 9 |
January 2025 | 4 |
January 2025 | 8 |
January 2025 | 4 |
January 2025 | 2 |
January 2025 | 2 |
January 2025 | 24 |
January 2025 | 3 |
January 2025 | 16 |
January 2025 | 4 |
January 2025 | 5 |
January 2025 | 9 |
January 2025 | 13 |
January 2025 | 5 |
January 2025 | 9 |
January 2025 | 7 |
January 2025 | 1 |
January 2025 | 10 |
January 2025 | 3 |
January 2025 | 5 |
January 2025 | 27 |
January 2025 | 1 |
January 2025 | 14 |
January 2025 | 6 |
February 2025 | 19 |
February 2025 | 7 |
February 2025 | 13 |
February 2025 | 12 |
February 2025 | 1 |
February 2025 | 36 |
February 2025 | 3 |
February 2025 | 20 |
February 2025 | 13 |
February 2025 | 10 |
February 2025 | 12 |
February 2025 | 3 |
February 2025 | 4 |
February 2025 | 6 |
February 2025 | 3 |
February 2025 | 6 |
February 2025 | 39 |
February 2025 | 4 |
February 2025 | 5 |
February 2025 | 6 |
February 2025 | 9 |
February 2025 | 2 |
February 2025 | 12 |
February 2025 | 5 |
February 2025 | 12 |
February 2025 | 10 |
February 2025 | 6 |
February 2025 | 19 |
February 2025 | 19 |
February 2025 | 12 |
February 2025 | 8 |
February 2025 | 3 |
February 2025 | 21 |
February 2025 | 2 |
February 2025 | 5 |
February 2025 | 47 |
February 2025 | 12 |
February 2025 | 24 |
February 2025 | 22 |
February 2025 | 32 |
February 2025 | 3 |
February 2025 | 2 |
February 2025 | 3 |
February 2025 | 11 |
February 2025 | 5 |
February 2025 | 22 |
February 2025 | 4 |
February 2025 | 6 |
March 2025 | 1 |
March 2025 | 27 |
March 2025 | 64 |
March 2025 | 1 |
March 2025 | 1 |
March 2025 | 43 |
March 2025 | 1 |
March 2025 | 2 |
March 2025 | 5 |
March 2025 | 3 |
March 2025 | 2 |
March 2025 | 3 |
March 2025 | 1 |
March 2025 | 23 |
March 2025 | 12 |
March 2025 | 2 |
March 2025 | 2 |
March 2025 | 3 |
March 2025 | 1 |
March 2025 | 8 |
March 2025 | 4 |
March 2025 | 3 |
March 2025 | 11 |
March 2025 | 14 |
March 2025 | 5 |
March 2025 | 4 |
March 2025 | 3 |
March 2025 | 1 |
March 2025 | 6 |
March 2025 | 3 |
March 2025 | 1 |
March 2025 | 3 |
March 2025 | 8 |
March 2025 | 7 |
March 2025 | 10 |
March 2025 | 15 |
March 2025 | 12 |
March 2025 | 45 |
March 2025 | 9 |
March 2025 | 15 |
March 2025 | 4 |
March 2025 | 1 |
March 2025 | 7 |
March 2025 | 1 |
April 2025 | 5 |
April 2025 | 6 |
April 2025 | 4 |
April 2025 | 4 |
April 2025 | 18 |
April 2025 | 4 |
April 2025 | 9 |
April 2025 | 4 |
April 2025 | 6 |
April 2025 | 18 |
April 2025 | 14 |
April 2025 | 4 |
April 2025 | 13 |
April 2025 | 6 |
April 2025 | 6 |
April 2025 | 9 |
April 2025 | 3 |
April 2025 | 19 |
April 2025 | 21 |
April 2025 | 7 |
April 2025 | 9 |
April 2025 | 8 |
April 2025 | 10 |
April 2025 | 22 |
April 2025 | 24 |
April 2025 | 5 |
April 2025 | 9 |
April 2025 | 12 |
April 2025 | 4 |
April 2025 | 20 |
April 2025 | 8 |
April 2025 | 4 |
April 2025 | 5 |
April 2025 | 8 |
April 2025 | 4 |
April 2025 | 7 |
April 2025 | 5 |
April 2025 | 4 |
April 2025 | 34 |
April 2025 | 17 |
April 2025 | 8 |
April 2025 | 19 |
April 2025 | 36 |
April 2025 | 9 |
April 2025 | 9 |
April 2025 | 13 |
April 2025 | 7 |
April 2025 | 4 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 2 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 2 |
May 2025 | 1 |
May 2025 | 1 |
May 2025 | 1 |
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