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2.5 Development of the cardiac conduction system
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Published:July 2018
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This version:July 2020
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Abstract
The contraction of the heart is orchestrated by the components of the cardiac conduction system (CCS), which initiate and propagate the electrical impulses to coordinately activate the cardiac chambers. In the adult heart, the impulse is generated in the sinoatrial node and activates the atrial myocardium. Slow conduction of the impulse through the atrioventricular node allows for emptying of the atria and filling of the ventricles prior to ventricular contraction. Subsequent fast conduction through the atrioventricular bundle, bundle branches, and Purkinje fibre network activates the ventricular myocardium and causes the ventricles to contract. The development and function of the CCS involves complex regulatory networks of transcription factors acting in stage-, tissue-, and dose-dependent manners. Disrupted function or expression of these factors might lead to impaired development or function of the CCS components, associated with heart failure and sudden death. It is therefore crucial to understand the molecular and cellular mechanisms controlling the complex regulation of CCS development. This chapter summarizes current insight in the development and function of the different compartments of the CCS, and discusses the transcriptional networks underlying these processes.
Update:
Sections ‘The origin and development of the sinoatrial node’ and ‘Transcriptional programming of the sinoatrial node’ have been updated
A ...More
Update:
Sections ‘The origin and development of the sinoatrial node’ and ‘Transcriptional programming of the sinoatrial node’ have been updated
A number of new references have been included in the chapter
This chapter has been updated to include links to enhanced, animated versions of figures
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