The spatiotemporal turnover of metabolites is essential for oocyte maturation, embryonic development, and cell lineage differentiation. Here, we analyzed the metabolic profiles of individual living mouse oocytes and studied how bisphosphoglycerate mutase (BPGM), an important maternal factor, influences metabolite ...

Cellular prion (PRNP) is a GPI anchored extrinsic membrane glycoprotein, which has been implicated in mouse decidualization. However, the molecular function of this protein, in mouse decidua is not known. In this report, we have characterized and elucidated the possible role of PRNP in mouse decidua. We demonstrated that ...

It is hypothesized that male fetuses are more vulnerable to in utero insults than females due to different growth strategies, and that the placenta contributes to these sex differences. We examined sex differences in the fetal and placental responses to maternal food restriction (∼60% of ad libitum) beginning mid-gestation ...

Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, and the inhibitory factor of TGF-β pathway, MADH7, makes a vital impact on the progression of fibrosis. Ovarian tumour domain-containing protein 1 (OTUD1) deubiquitinase binds to the MADH7 protein, ...

Exposure to PM2.5 (particulate matter <2.5 μm) has been implicated in increasing the risk of endometriosis and worsening its symptoms. However, the molecular mechanisms and direct associations remain unclear. This study explored whether PM2.5 contributes to the onset or progression of endometriosis using in vitro and in ...

This is a correction to: Yuying Zhang, Lingtao Yang, Dongyong Yang, Songchen Cai, Yanjun Wang, Linlin Wang, Yuye Li, Longfei Li, Tailang Yin, Lianghui Diao, Understanding the heterogeneity of natural killer cells at the maternal–fetal interface: implications for pregnancy health and disease, Molecular Human Reproduction , ...

Aneuploidy in embryos poses a major barrier to successful human reproduction, contributing to nearly 50% of early miscarriages. Despite its high prevalence in human embryos, the molecular mechanisms regulating aneuploid cell fate during development remain poorly understood. This knowledge gap persists due to ethical ...

Reverse genetic approaches are the standard in molecular biology to determine a protein’s function. Traditionally, nucleic acid targeting via gene knockout (DNA) and knockdown (RNA) has been the method of choice to remove proteins-of-interest. However, the nature of mammalian oocyte maturation and preimplantation embryo ...

The activation of dormant primordial follicles is a promising method to improve the fertility of premature ovarian insufficiency (POI) patients. Many experiments from both human and animal studies suggest that human platelet-rich plasma (hPRP) may restore ovarian function and promote follicle growth. However, the ...

Among rare cases of teratozoospermia, MMAF (multiple morphological abnormalities of the flagellum) syndrome is a complex genetic disorder involving at least 70 different genes. As the name suggests, patients with MMAF syndrome produce spermatozoa with multiple flagellar defects, rendering them immobile and non-fertilizing, ...