Critical Thinking in Clinical Research: Applied Theory and Practice Using Case Studies (1)
Critical Thinking in Clinical Research: Applied Theory and Practice Using Case Studies (1)
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Abstract
Critical Thinking in Clinical Research explains the fundamentals of clinical research in a case-based approach. The core concept is to combine a clear and concise transfer of information and knowledge with an engagement of the reader to develop a mastery of learning and critical thinking skills. The book addresses the main concepts of clinical research, basics of biostatistics, advanced topics in applied biostatistics, and practical aspects of clinical research, with emphasis on clinical relevance across all medical specialties. The goal of the book is to give a comprehensive and basic overview of the field of clinical research. This book has been designed on the experience of leading a large course in clinical research: the Principles and Practice in Clinical Research (PPCR), offered currently by Harvard T. H. Chan School of Public Health; it was written by PPCR collaborators together with PPCR faculty to reflect the collaborative learning concept of the course. The goal of this book is to provide a broad and applicable introduction into clinical research that allows the reader to understand, design, and conduct clinical research, specifically to critically read and understand scientific papers; to collect, analyze, and interpret research data in an unbiased fashion; to develop and design clinical studies; and to prepare, publish, and review scientific manuscripts. It is therefore written for scientists and clinicians who are new to the field of clinical research as well as those who wish to deepen, broaden, and update their clinical research skills.
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Front Matter
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Unit I Basics of Clinical Research
Rui Nakamura,Faiza Khawaja,-
1
Basics of Clinical Research: Introduction to Clinical Research
Rui Nakamura and others
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2
Selection of the Research Question
Keiko Ueda and others
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3
Study Population
Sandra Carvalho and others
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4
Basic Study Designs
Alexandra Gomez and others
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5
Randomization
Juliana C Ferreira and others
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6
Blinding
Rita Tomás and others
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7
Recruitment and Adherence
Claudia Kimie Suemoto and others
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1
Basics of Clinical Research: Introduction to Clinical Research
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Unit II Basics of Statistics
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8
Basics of Statistics
Claudia Kimie Suemoto and others
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9
Parametric Statistical Tests
Ben M. W. Illigens and others
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10
Non-Parametric Statistical Tests
Felipe Fregni and others
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11
Sample Size Calculation
Mohammad Azfar Qureshi and others
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12
Survival Analysis
Jorge Leite and others
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13
Other Issues in Statistics I: Missing Data, Intention-to-Treat Analysis, and Covariate Adjustment
Tamara Jorquiera and others
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14
Other Issues in Statistics II: Subgroup Analysis and Meta-analysis
Jorge Leite and others
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8
Basics of Statistics
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Unit III Practical Aspects of Clinical Research
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Unit IV Study Designs
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19
Integrity in Research: Authorship and Ethics
Sandra Carvalho and others
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20
The Business of Clinical Research
Lívia Caroline Mariano Compte and others
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21
Design and Analysis of Surveys
Ana R Martins and others
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22
Assessing Risk and Adverse Events
Laura Castillo-Saavedra and others
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23
Manuscript Submission
Alma Tamara Sanchez Jimenez andFelipe Fregni
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19
Integrity in Research: Authorship and Ethics
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End Matter
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