
Contents
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Introduction Introduction
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Direct lymphoma effects Direct lymphoma effects
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Central nervous system involvement Central nervous system involvement
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Primary central nervous system lymphoma Primary central nervous system lymphoma
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Secondary central nervous system involvement in systemic lymphoid malignancies Secondary central nervous system involvement in systemic lymphoid malignancies
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Central nervous system involvement in high-grade non-Hodgkin lymphoma Central nervous system involvement in high-grade non-Hodgkin lymphoma
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Central nervous system involvement in indolent non-Hodgkin lymphoma Central nervous system involvement in indolent non-Hodgkin lymphoma
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Central nervous system involvement in Hodgkin lymphoma Central nervous system involvement in Hodgkin lymphoma
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Central nervous system involvement in acute lymphoblastic leukaemia Central nervous system involvement in acute lymphoblastic leukaemia
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Central nervous system involvement in multiple myeloma Central nervous system involvement in multiple myeloma
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Peripheral nervous system involvement Peripheral nervous system involvement
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Indirect lymphoma effects Indirect lymphoma effects
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Spinal cord compression Spinal cord compression
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Paraneoplastic neurological syndromes Paraneoplastic neurological syndromes
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Paraprotein-associated neuropathy Paraprotein-associated neuropathy
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Vascular complications Vascular complications
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Intravascular lymphoma Intravascular lymphoma
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Conclusions Conclusions
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References References
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7 Neurological complications of lymphoid malignancies
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Published:July 2024
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Abstract
Lymphoid malignancies can involve both the central and peripheral nervous systems and may present in various ways. The central and peripheral nervous systems can be affected directly by primary central nervous system lymphoma or metastatic or local spread of systemic lymphoma. Indirect effects include spinal cord compression, paraneoplastic syndromes, and vascular involvement. Moreover, various treatment strategies for lymphoid malignancies can negatively affect the central and peripheral nervous systems. Early and adequate diagnosis of neurological complications can be challenging but is required in order to initiate appropriate treatment strategies and to possibly reverse the progression of symptoms. This chapter provides an overview of various neurological effects caused by lymphoid malignancies.
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