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Impaired Mitochondrial Biogenesis Inhibits Epithelial-Mesenchymal Transition in Villi of PCOS Patients
Hui-Ying Jie and others
Context Polycystic ovary syndrome (PCOS) is accompanied by impaired mitochondrial biogenesis in the ovary and uterus. Whether impaired mitochondrial biogenesis exhibits in villi of PCOS, and its effect and underlying mechanism remain unclear. Objective This work aimed to investigate mitochondrial biogenesis status and ...
Ligand Specific Estrogen Receptor alpha Conformational Dynamics
Sean William Fanning and others
Estrogen receptor alpha is overexpressed in 70 percent of breast cancers. Normally, ER-alpha remains inactive and sequestered in the cytoplasm until estrogen binds to the ligand-binding domain (LBD) to enable nuclear translocation, coregulator recruitment, and subsequent activation of proliferative ER-alpha-dependent ...
A Novel Cluster 3 Endometrial Cancer PDX Model to Test Hormone Therapy Regimens
Kimberly K Leslie and others
Endometrial cancer is the most commonly diagnosed gynecologic cancer and continues to rise in incidence and mortality rates worldwide. With the evaluation of large datasets including the TCGA, endometrial cancers have been subdivided into four different cluster groups based on molecular characteristics. The most common ...
Interrogating Steroid Hormone Signaling in a Murine Model of ER+ Human Breast Cancer Bone Metastases
Amanda L Babcock and others
While the importance of estrogen in driving ER+ breast cancer progression is clear, data from pre-clinical studies exploring the role of tumoral progesterone (PR) and androgen (AR) receptors are conflicting, likely due in part to the promiscuity of steroid receptor ligands, as well as relative levels of steroid hormone ...
Aberrant Expression of Estrogen Receptor alpha is Strongly Associated with Progesterone Receptor in the Endometrium from Infertile Women with Endometriosis
Soo Lim Kim and others
Estrogen receptors (ESRs) and progesterone receptor (PGR) are nuclear receptors that regulate signaling pathways in the endometrium that are critical for endometrial receptivity and the establishment of pregnancy. Endometriosis is a chronic condition characterized by the growth of endometrial tissue outside the uterine ...
Proteomic and Transcriptomic Analysis of Human Colonoids Exposed to Bacterial Serine Protease, EspP
Myranda N Thompson and others
Gut regeneration mechanisms remain an important, yet elusive, facet of intestinal injury research. The intestinal epithelium must be intact for critical gut functions to remain in place, yet injury via microbe interactions or environmental toxicants is common. EspP is a potent serine. EspP is a potent serine protease that ...
Genetic E-Cadherin Loss Creates a Distinct Phenotype in an Early ILC Tumorigenesis Model
Maggie Musick and others
Invasive lobular carcinoma (ILC) is a common subtype of breast cancer, and despite being ∼95% estrogen receptor α positive (ER+) with other ‘low risk’ biomarkers, ILC has the highest risk of long-term recurrence among breast cancers. ILC are genetically distinct, with hallmark mutation/deletion of CDH1 leading to loss of ...
Tumor promoting functions of NIK/MAP3K14 in the Glioblastoma Microenvironment: Implications for Sex-Differences in Therapeutic Responses
Hasara Abeygutaratne and others
Glioblastoma multiforme (GBM) is the most common and deadliest primary malignant brain tumor in adults due to its aggressive, invasive growth and therapy resistance. The GBM tumor microenvironment (TME) is highly infiltrated by tumor associated macrophages and microglia (TAMMs) that undergo metabolic reprogramming and ...
Loss of ERα Phosphorylation at Serine 167 and Serine 212 Alters the ERα transcriptome/cistrome, Impacting Breast Cancer Growth, Tamoxifen Response, Mouse Fertility, Aging and Metabolism
Binghao Zou and others
Estrogen receptor alpha (ERα) is a ligand-dependent transcription factor which has multiple phosphorylation sites. Phosphorylation at serine (S) 167 is associated with increased overall survival in breast cancer (BC) patients treated with adjuvant tamoxifen. S212 is a highly conserved phosphorylation site located in the ...
Regulation of Super Enhancers by Phosphorylated Progesterone Receptors Drives Breast Cancer Stem Cell Expansion
Noelle E Gillis and Carol A Lange
Current treatments for estrogen receptor (ER) positive breast cancer largely target rapidly dividing tumor cells. However, aggressive breast cancers often contain long-lived and weakly proliferative cancer stem cells (CSCs) that readily escape treatments aimed at cycling cells. Furthermore, up to 40% of endocrine ...

Endocrinology Areas of Focus:

  • Adrenal
  • Diabetes, Pancreatic and Gastrointestinal Hormones
  • Endocrine Disrupting Chemicals
  • Growth, Growth Hormone, and Growth Factors
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  • Lipids and Cardiovascular
  • Nuclear Receptors and their Ligands
  • Obesity and Adipocyte Biology
  • Parathyroid, Bone, and Mineral Metabolism
  • Pituitary and Neuroendocrinology
  • Reproductive Biology and Sex-Based Medicine
  • Signaling Pathways
  • Thyroid
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Endocrinology's former Editor-in-Chief, Carol A Lange, PhD, and Stephen R Hammes, MD, PhD, past Editor-in-Chief of Molecular Endocrinology share critical tips on how to get published.

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