Volume 102, Issue 3, 1 March 2017

The objective is to formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity.

We conducted an umbrella systematic review of randomized controlled trials to assess the quality of evidence and effectiveness of different interventions to treat pediatric obesity.

The source and impact of tetrac are uncertain. We report serum tetrac levels positively correlate with T4. Several cell-types convert T4 to tetrac, which enhances the actions of TSH and TSI.

This study describes the use of dehydroepiandrosterone sulfate as a sensitive and specific screening test for subclinical hypercortisolism in the context of adrenal incidentalomas.

We studied about the initial and dynamic risk stratification in pediatric patients with DTC and found that it could provide useful prognostic information to predict persistent/recurrent disease.

We comprehensively investigated glycemic predictors of insulin independence after TPIAT using OGTT. Lower OGTT glucose levels and higher HOMA-β were predictors of insulin independence.

We found serum lipid profiles changed in women with PCOS. Obesity and compensatory hyperinsulinemia promoted the metabolism of arachidonic acid and other PUFAs, whereas androgen had an inhibitory effect.

Nifedipine therapy was assessed in 11 children with hyperinsulinemic hypoglycemia due to mutations in the ABCC8 gene, and it was found to be ineffective in glycemic control.

VLDL-TG storage in muscle and adipose tissue was measured in relation to LPL activity. Men with type 2 diabetes have increased VLDL-TG storage in muscle tissue, not related to LPL activity.

We analyzed the androgen metabolome in women with polycystic ovary syndrome by mass spectrometry, revealing that 11-oxygenated androgens represent the majority of circulating androgen excess.

This is a retrospective study that assessed if the maternal and neonatal outcomes for women with gestational diabetes treated with insulin are comparable to women with normal glucose tolerance.

We studied the effects of the addition of fiber to a high-fat meal, and we found that fiber suppressed meal-induced inflammation and oxidative stress.

We studied the mortality risk due to dementia in women with HT use, and show that HT use is associated with a larger reduction in the death risk for vascular dementia than for Alzheimer's disease.

We report reassuring results of a longitudinal retrospective study on the influence of GH treatment on glucose homeostasis in girls with Turner syndrome.

Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese population.

High-sensitive thyroglobulin measured 3 to 4 months after total thyroidectomy is important in the risk restratification of DTC patients but less relevant than neck US in the decision to perform RRA.

We studied pregnant women in a large European multicenter randomized controlled trial of physical activity and/or healthy eating and found no effect on gestational diabetes mellitus risk, despite the significant gestational weight gain limitation.

We present an analysis of bone fractures observed in a placebo-controlled randomized clinical trial of pioglitazone for secondary prevention in 3876 nondiabetic patients with cerebrovascular disease.

We studied tumor DNA methylation by MS-MLPA in 203 patients with ACC and found that methylation is a strong prognostic factor, independent of tumor stage and Ki67.

ATF4 targets RET for degradation, act as a candidate tumor suppressor gene, and may be a molecular marker that distinguishes patients at high risk of MTC from those with a longer survival prognosis.

We studied 5 children with UCP2-inactivating mutations that cause diazoxide-responsive congenital HI. We found that UCP2 mutation carriers have unusual hypersensitivity to glucose-induced hypoglycemia.

Expression of VDR in high-quality spermatozoa implies that 1,25(OH)₂D₃ may assist in selection of the best gametes for fertilization if the demonstrated effects can be extrapolated to the clinic.

We studied cortisol responses to acute mental stress and found that larger responses predicted accelerated leukocyte telomere attrition over 3 years in healthy older men and women.

Obese adolescents with and without PCOS have significantly elevated fasting and postprandial plasma TG and ApoB-lipoprotein levels, indicating early subclinical CVD risk.

This study shows that GH-treated SRS patients have a similar metabolic health and safety profile as non-SRS subjects born SGA during and until 2 years after cessation of GH.

A single high or low vitamin D3 dose decreased fasting C3 levels, but did not reduce postprandial arterial stiffness or inflammation in 24 overweight, vitamin D–deficient women.

Transient thelarche (the onset and subsequent regression of breast buds) in healthy girls was found to be a frequent, and likely peripheral, phenomenon independent of central puberty.

BMP15 mutations associated with POI reduce mature protein synthesis, activity, or synergy with GDF9. The latter effect is notable as synergy with GDF9 may underlie BMP15 physiology in the human ovary.

Complete response after first reoperation for persistent/recurrent DTC was 63%. Factors for incomplete response after first reoperation were male sex and aggressive histopathological subtype.

An in vitro model of adipose tissue extracellular matrix repopulated with adipocytes was used to demonstrate that the extracellular matrix regulates adipocyte metabolism in a disease-specific manner.

Birth weight in disorders of androgen synthesis and androgen excess groups was similar to healthy children with the same karyotype. Birth weight dimorphism cannot be explained by fetal androgen action.

We investigated 8917 patients treated for pituitary sellar lesions. Compared with surgery, radiotherapy was accompanied by a threefold to fourfold higher risk of developing malignant brain tumors and meningiomas.

This study tests in a large cohort whether the relationships between TSH and fT4 levels in early pregnancy and fetal growth outcomes are modified by fetal sex.

In this perspective, we provide a holistic management approach to middle-aged and older men with functional hypogonadism.

Androgen deprivation therapy for prostate cancer reduces muscle mass. This study demonstrates that protein intake and resistance exercise combined helps mitigate lean mass loss during treatment.