Volume 102, Issue 4, 1 April 2017

Acute experimental hypercortisolemia induces differential metabolic responses in abdominal and femoral adipose tissue in vivo, suggesting depot-specific glucocorticoid effects in humans.

We measured AMH and AFC in IHH/KS women and studied the effect of FSH. In IHH/KS, AMH and AFC were low, a decrease that can be reversed by FSH. They are not prognostic markers of fertility in IHH/KS.

Increased visceral adiposity and higher fasting insulin levels in insulin-resistant states are associated with lower fasting osteocalcin and C-telopeptide and failure to further suppress with insulin.

This study establishes the link between extraadrenal, multifocal, metastatic, reccurent, hereditary PPGLs to a higher prevalence of noradrenergic and cluster 1 tumors in pediatric than adults.

We studied effects of 20 μg/d of calcifediol vs 60 μg/d of cholecalciferol and found calcifediol to more rapidly and robustly raise total and free 25D levels in a diverse sample of adults.

We demonstrate increased adipocyte size, along with an altered endocrine function and altered lipid turnover in cultured preadipocytes isolated from offspring exposed to hyperglycemia in utero.

The authors examine predictors of FGF23 in a cohort of healthy girls ages 9 to 18 years and find it to be correlated with decreased urinary calcium but not with measures of phosphate homeostasis.

We cross-calibrated cohort-specific assays to a reference method at CDC and generated harmonized reference ranges for circulating testosterone levels in men, including age-adjusted reference ranges.

In this study, we evaluated serum levels of sclerostin and DKK-1, bone formation inhibitors, and the influence of glycemic control on bone health in children with T1DM.

We reviewed CYP11B2 immunolocalization and aldosterone-driver gene somatic mutation status of cross-sectional image–negative hyperaldosteronism and developed histological classification.

A one-step hyperinsulinemic-euglycemic clamp with FFA tracers and Adipo-IR correlate with a gold standard measure of adipose insulin sensitivity, but age and physical fitness affect the relationships.

BAT and WAT was studied with 1H-MRS and 18-F-FDG PET. Temperature and FF from 1H-MRS correlated with PET. 1H-MRS thermometry and FF are promising tools to study BAT activity.

In patients with pheochromocytoma, vascular and myocardial abnormalities regressed after adrenalectomy. This contrasted with nearly an opposite trend in patients with essential hypertension.

We studied QoL in adult survivors of pediatric DTC compared with matched controls and found an overall normal QoL in survivors. Mild impairment of QoL was seen in some domains of QoL.

We studied the link between physical activity and vitamin D level. We found a linear association in whites but not blacks. Vitamin D and physical activity jointly influence cardiovascular disease risk.

We found primary aldosteronism (PA) as a risk factor for prevalent vertebral fracture. In addition, fracture severity was significantly higher in patients with PA than in age- and sex-matched controls.

We studied the endometrium of obese women with polycystic ovarian syndrome and found that lifestyle intervention improved progesterone receptor expression and decreased proliferation in the secretory phase.

Bone events in patients with thyroid cancer are a poor prognostic indicator. Patients with follicular and medullary thyroid cancers are at especially high risk for skeletal complications.

We evaluated EMT in the human amnion and found that labor and PPROM are associated with increased amniotic EMT compared with unlabored cesarean delivery.

Use of thiazides in patients with primary hyperparathyroidism is controversial. This study shows significant reduction in hypercalciuria without exacerbation of hypercalcemia in patients with primary hyperparathyroidism who received thiazide therapy.

We studied whether markers at type 1 diabetes diagnosis were predictive of later autoimmune thyroid disease. We found that TPOAb and TSH as well as GADA were predictive in girls ˂5 years old at diagnosis.

We studied education and practice of transgender health and found low confidence in management of nonhormonal topics. Barriers to providing education included lack of faculty interest or expertise.

The prevalence of diabetes in young adults treated with GH during childhood was compared with the general population in France. No difference in oral drugs- or insulin-treated diabetes was found.

TGF-β1 and downstream SMADs were decreased in perimenstrual endometrium from women with heavy menstruation versus controls. TGF-β1 was activated by cortisol in endometrial cells and enhanced repair.

This is a large cohort study based on elderly, and results showed that there is an independent association between NAFLD and both diabetes and prediabetes, which was closely related to BMI changes.

Preoperative and postoperative TSH levels are important to predict postlobectomy hypothyroidism. Mild postoperative hypothyroidism should be followed up with the expectation of spontaneous recovery.

Chronic intranasal insulin does not affect hepatic lipid content but lowers circulating branched-chain amino acid levels in nonobese male human subjects.

This retrospective study assessing effects of bisphosphonates on femoral fractures in children with OI showed that fracture characteristics are affected by OI type but not by bisphosphonate exposure.

Administration of the growth hormone antagonist pegvisomant during 72 hours fasting in obese subjects reverses insulin resistance and amplifies insulin-stimulated suppression of lipid intermediates.

BPA urinary concentrations during early 2nd trimester, but not the 1st trimester, are positively associated with maternal glucose levels in late 2nd trimester among women seeking infertility treatment.

This analysis confirms that adjuvant mitotane in radically resected patients with ACC is associated with prolonged RFS and overall survival independently of tumor hormone activity.

Maternal cortisol concentration during the early third trimester of pregnancy was significantly associated with a greater increase in infant adiposity over the first 6 months of postnatal life.

We studied the effects of oral D-galactose therapy in patients with TMEM165-CDG. We found that abnormal glycosylation and clinical parameters could be improved by galactose treatment.

In this cross-sectional analysis of the Multi-Ethnic Study of Atherosclerosis, higher adiposity was associated with higher fibroblast growth factor 23 levels, independent of phosphate and eGFR.

Global DNA methylation is unaltered in blood leukocytes and granulosa cells of women with PCOS. However, a LINE1 methyl-CpG site showed consistent hypomethylation and association with PCOS and its traits.