Janus kinase (JAK) inhibitors are small-molecule therapeutics that reduce inflammation in autoimmune and inflammatory diseases by modulating the JAK-STAT pathway. While effective in alleviating immune-mediated conditions, JAK inhibitors can impair antiviral defences by suppressing interferon (IFN) ...

Sexual dimorphism in mouse gonads becomes evident at around E12.5, followed by germ cell differentiation. While prior studies have concentrated on protein-coding genes, our research expands this by profiling the complete spectrum of stranded RNAs including long and short RNAs in one preparation. We ...

Autoimmune diseases are caused by the misdirection of the immune system as the side effect of antibody diversity, wherein each B cell possesses unique characteristics defined by its antibodies. To address this issue, I have developed several cell surface immunoglobulin (Ig)-Aimed Immune Memory ...

Macrophages represent a major immune cell type in tumor microenvironments, they exist in multiple functional states and are of strong interest for therapeutic reprogramming. While signaling cascades defining pro-inflammatory macrophages are better characterized, pathways that drive polarization in ...

To date, there is an unmet need for novel approaches that address haploinsufficiency disorders in a targeted and robust manner. Here, we developed a novel, modular tool for transcriptional regulation of genes involved in neurodevelopmental disease in the absence of creating double-stranded breaks. ...