A 65-year-old male with asthma and bronchiectasis was admitted to our hospital for mild respiratory exacerbation. At the time, the ward of admittance was handling a carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak, and the patient underwent collection of surveillance swabs upon ...
Latest Published Articles
Objectives Cefiderocol has emerged as a key treatment for managing MDR infections, and its time-dependent pharmacodynamics are optimized by prolonged infusion to maintain time above the MIC ( T > MIC ). Whereas recent stability studies have shown cefiderocol remains stable up to 72 h in ...
Background Acinetobacter baumannii has become an increasingly urgent public health concern among global health agencies due to high rates of carbapenem resistance. Carbapenem-resistant A. baumannii (CRAB) that express both oxacillinases and MBLs is especially problematic due to resistance to all ...
Background Candida parapsilosis is an opportunistic pathogen with increasing rates of resistance to fluconazole and voriconazole. Recently, in an outbreak at the Azienda Ospedaliero-Universitaria Pisana, a new amino acid substitution, S862C in the CpMrr1 protein, was found only in azole-resistant ...
Background Research on the effectiveness of Japan’s national action plan on antimicrobial resistance, including among individuals with HIV, remains scarce. Objectives To evaluate the impact of policies on antibiotic prescription practices. Methods Outpatient oral antibiotic prescription data from ...
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These evidence-based guidelines are an updated version of those issued in 2008. They have been produced following a review of the published literature (2007–18) pertaining to the treatment of infections caused by MRSA. The guidelines update, where appropriate, previous recommendations, taking into account changes in the UK ...
Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the early 1980s, they have spread worldwide and an are now endemic in Enterobacterales isolated from both hospital-associated and community-acquired ...
Carbapenem-resistant Acinetobacter baumannii (CRAB) is characterized as a critical priority pathogen with restricted therapeutic options. To date, the most effective antimicrobial treatment against this difficult-to-treat bacterial strain has not been established. Sulbactam is a β-lactamase inhibitor with intrinsic ...
Background Reducing antibiotic duration is a key stewardship intervention to mitigate antimicrobial resistance (AMR). We examined current evidence informing antibiotic duration for common bacterial infections to identify any gaps in terms of settings, patient populations and infectious conditions. Trial methodologies were ...
Antimicrobial resistance (AMR) is a growing global health threat, which is increasingly quantified in terms of its human health and economic burden. In this article, we highlight that for policy and planning purposes the social burden of AMR is as important to attend to as health and economic burdens, requiring systematic ...
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