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Viral suppression after failure of PI-based ART among adolescents and youths with and without drug resistance mutations: a longitudinal analysis in Tanzania
Joan Rugemalila and others
Background People living with HIV (PLHIV) who fail first-line ART have a higher risk of failing subsequent ART. We examined viral suppression (VS) among adolescents and youths (AY) failing PI ART in Tanzania. Methods We conducted a retrospective study nested within a national third-line cohort of ...
Activity of rezafungin against Candida auris
Jeffrey B Locke and others
The increasing prevalence of candidemia and invasive candidiasis infections caused by Candida auris represents a global health risk. Such infections are difficult to treat as they are often multidrug-resistant and are linked to high rates of mortality. Rezafungin is a second-generation echinocandin ...
Ibrexafungerp prolongs survival and reduces the eumycetoma grain size in Galleria mellonella infection models of two different causative agents of eumycetoma
Jingyi Ma and others
Objectives Eumycetoma is a neglected tropical fungal disease of the subcutaneous tissue that is currently not treatable with medication only. Standard itraconazole therapy is combined with surgical excision of the lesion. Recently, ibrexafungerp, a novel oral antifungal agent inhibiting 1,3-β- D- ...
A comparative study of the molecular characteristics of human uropathogenic Escherichia coli collected from two hospitals in Norway and France in 2019
Nina Handal and others
Background Escherichia coli is the primary aetiological agent of urinary tract infections (UTIs), a frequent cause of antibiotic prescription. Over the years, E. coli has become increasingly resistant towards several antimicrobial drugs used to treat UTIs. Objectives To compare the population ...
Isavuconazole therapeutic drug monitoring and association with adverse events
Emily Huang and others
Objectives Isavuconazole is efficacious in the treatment of aspergillosis, mucormycosis, and other invasive fungal infections. Therapeutic drug monitoring is generally not assessed during treatment with isavuconazole due to its high oral bioavailability, modest drug–drug interactions, and linear ...
Antibiotic treatment of Stenotrophomonas maltophilia bacteraemia: does trimethoprim/sulfamethoxazole dose affect clinical outcomes?
Wei-Ping Chen and others
Objectives The benefit of high-dose trimethoprim/sulfamethoxazole (trimethoprim component ≥ 8 mg/kg/day) treatment for Stenotrophomonas maltophilia infections remains unclear. We aimed to evaluate the effect of high-dose trimethoprim/sulfamethoxazole treatment on outcomes in patients with S. ...
Impact of the inoculum effect on cefepime activity against AmpC-hyperproducing Enterobacter spp.: insights into resistance mechanisms
Ángel Rodríguez-Villodres and others
Background Antimicrobial resistance among Enterobacter spp. is a significant concern in healthcare settings due to their ability to hyperproduce AmpC β-lactamase, thereby limiting therapeutic options. Cefepime is recommended for treating these infections; however, its efficacy might be compromised ...
Effect of body mass index on the timing of therapeutic drug monitoring—guided dalbavancin dosing in patients with osteoarticular infections
Dario Cattaneo and others
Background Recently, we documented that proactive therapeutic drug monitoring (TDM) allowed the successful individualization of the timing of dalbavancin administration in patients requiring prolonged antibiotic treatment. Here, we aimed to identify variables associated with the timing of ...
Therapeutic drug monitoring in anti-tuberculosis treatment: a systematic review
Youssra Metarfi and others
Background and objectives The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is essential for optimizing ...
Ultrasound for long-acting injectable cabotegravir and rilpivirine in transgender individuals with implants: a new opportunity for normalization
Jesús Troya and others
Long-acting injectable (LAI) cabotegravir and rilpivirine have become a convenient alternative to daily oral antiretrovirals, offering monthly or bi-monthly intramuscular injections based on data from clinical trials and real-world evidence. 1–5 However, certain groups, such as transgender ...
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